Annotations: 2YDS

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Hyaluronidase post-catalytic domain-like	8038622	3001475	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	(Trans)glycosidases	8038623	3000313	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	beta-N-acetylhexosaminidase-like domain	8038626	3000192	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	NagJ_C	e2ydsA9	A: alpha bundles	X: Hyaluronidase domain-like	H: Hyaluronidase post-catalytic domain-like (From Topology)	T: Hyaluronidase post-catalytic domain-like	F: NagJ_C	ECOD (1.6)
A	NAGidase	e2ydsA8	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: NAGidase	ECOD (1.6)
A	Glyco_hydro_20b	e2ydsA7	A: mixed a+b and a/b	X: Zincin-like	H: beta-N-acetylhexosaminidase-like domain (From Topology)	T: beta-N-acetylhexosaminidase-like domain	F: Glyco_hydro_20b	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.379.10	Alpha Beta	2-Layer Sandwich	Chitobiase	domain 2	CATH (4.3.0)
A	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)
A	1.20.58.460	Mainly Alpha	Up-down Bundle	Methane Monooxygenase Hydroxylase	Chain G, domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF21774	Hyaluronidase post-catalytic domain-like (NagJ_C)	Hyaluronidase post-catalytic domain-like	This domain is located at the C-terminus of proteins that are members of family 84 glycoside hydrolases.These enzymes directly hydrolyse O-GlcNAcylated peptides/proteins. This domain folds into a five helical bundle with up-and-down topology. It may ...	This domain is located at the C-terminus of proteins that are members of family 84 glycoside hydrolases.These enzymes directly hydrolyse O-GlcNAcylated peptides/proteins. This domain folds into a five helical bundle with up-and-down topology. It may function in substrate binding or recognition [1-5].	Domain
A	PF02838	Glycosyl hydrolase family 20, domain 2 (Glyco_hydro_20b)	Glycosyl hydrolase family 20, domain 2	This domain has a zincin-like fold.	Domain
A	PF07555	beta-N-acetylglucosaminidase (NAGidase)	beta-N-acetylglucosaminidase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	O-GLCNACASE NAGJ	binding carbohydrate binding hydrolase activity, acting on glycosyl bonds hexosaminidase activity beta-N-acetylhexosaminidase activity beta-N-acetylglucosaminidase activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity catalytic activity [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine/L-threonine O-N-acetyl-alpha-D-glucosaminase activity catalytic activity, acting on a protein	carbohydrate metabolic process primary metabolic process metabolic process macromolecule modification protein deglycosylation carbohydrate derivative metabolic process protein metabolic process macromolecule metabolic process protein modification process glycoprotein metabolic process polysaccharide metabolic process catabolic process polysaccharide catabolic process carbohydrate catabolic process carbohydrate metabolic process primary metabolic process metabolic process macromolecule modification protein deglycosylation carbohydrate derivative metabolic process protein metabolic process macromolecule metabolic process protein modification process glycoprotein metabolic process polysaccharide metabolic process catabolic process polysaccharide catabolic process carbohydrate catabolic process macromolecule catabolic process	-
B [auth T]	TGF-BETA-ACTIVATED KINASE 1 AND MAP3K7-BINDING PROTEIN 1	phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity protein binding binding kinase binding enzyme binding mitogen-activated protein kinase p38 binding protein kinase binding phosphoric ester hydrolase activity phosphoprotein phosphatase activity protein serine/threonine phosphatase activity catalytic activity, acting on a protein hydrolase activity, acting on ester bonds phosphatase activity hydrolase activity catalytic activity protein binding binding kinase binding enzyme binding mitogen-activated protein kinase p38 binding protein kinase binding mitogen-activated protein kinase binding protein-containing complex binding molecular adaptor activity enzyme regulator activity protein serine/threonine kinase activator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity protein kinase activator activity protein kinase regulator activity kinase regulator activity	cellular response to stimulus positive regulation of cell communication positive regulation of response to biotic stimulus regulation of cellular process positive regulation of signal transduction pattern recognition receptor signaling pathway response to stimulus regulation of signal transduction response to biotic stimulus intracellular signal transduction cGAS/STING signaling pathway cell communication immune response-activating signaling pathway positive regulation of immune response cellular response to stimulus positive regulation of cell communication positive regulation of response to biotic stimulus regulation of cellular process positive regulation of signal transduction pattern recognition receptor signaling pathway response to stimulus regulation of signal transduction response to biotic stimulus intracellular signal transduction cGAS/STING signaling pathway cell communication immune response-activating signaling pathway positive regulation of immune response regulation of immune system process signal transduction positive regulation of immune system process innate immune response-activating signaling pathway regulation of biological process positive regulation of pattern recognition receptor signaling pathway immune response response to other organism regulation of innate immune response response to external stimulus positive regulation of intracellular signal transduction positive regulation of cGAS/STING signaling pathway regulation of response to stimulus defense response to other organism regulation of pattern recognition receptor signaling pathway positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response cytoplasmic pattern recognition receptor signaling pathway regulation of defense response regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of response to external stimulus intracellular receptor signaling pathway signaling positive regulation of biological process regulation of cytoplasmic pattern recognition receptor signaling pathway positive regulation of response to stimulus positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of intracellular signal transduction regulation of response to stress response to stress innate immune response response to external biotic stimulus positive regulation of cellular process regulation of signaling positive regulation of innate immune response defense response biological regulation defense response to symbiont immune system process regulation of cell communication cellular process positive regulation of signaling developmental process heart development multicellular organism development multicellular organismal process cardiac septum development cardiac chamber development anatomical structure development animal organ development circulatory system development system development tube development respiratory tube development lung development respiratory system development artery development aorta development vasculature development blood vessel development non-canonical NF-kappaB signal transduction intracellular signaling cassette embryo development ending in birth or egg hatching chordate embryonic development embryo development in utero embryonic development heart morphogenesis anatomical structure morphogenesis animal organ morphogenesis positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade positive regulation of phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of protein serine/threonine kinase activity positive regulation of metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process phosphorus metabolic process protein modification process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation cellular metabolic process regulation of protein metabolic process regulation of cellular metabolic process primary metabolic process regulation of molecular function positive regulation of kinase activity regulation of kinase activity macromolecule modification regulation of protein serine/threonine kinase activity regulation of phosphorus metabolic process metabolic process macromolecule metabolic process regulation of metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of cellular metabolic process positive regulation of molecular function positive regulation of protein modification process protein metabolic process positive regulation of protein kinase activity positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity regulation of macromolecule metabolic process regulation of phosphorylation coronary vasculature development cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway cell surface receptor signaling pathway cellular response to transforming growth factor beta stimulus response to endogenous stimulus cellular response to endogenous stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway enzyme-linked receptor protein signaling pathway	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen cellular anatomical entity intracellular membrane-bounded organelle intracellular organelle lumen nuclear speck nuclear body intracellular organelle nucleoplasm organelle lumen organelle nuclear lumen cytoplasm cytosol protein-containing complex organelle subcompartment membrane endomembrane system endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum organelle membrane endoplasmic reticulum membrane endosome membrane endosome intracellular vesicle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR051822	Glycosyl Hydrolase Family 84	Family
A	IPR017853	Glycoside hydrolase superfamily	Homologous Superfamily
A	IPR003961	Fibronectin type III	Domain
A	IPR029018	Beta-hexosaminidase-like, domain 2	Homologous Superfamily
A	IPR011496	Beta-N-acetylglucosaminidase, catalytic domain	Domain
A	IPR008965	CBM2/CBM3, carbohydrate-binding domain superfamily	Homologous Superfamily
A	IPR008979	Galactose-binding-like domain superfamily	Homologous Superfamily
A	IPR002102	Cellulosome anchoring protein, cohesin domain	Domain
A	IPR000421	Coagulation factor 5/8, C-terminal domain	Domain
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR015882	Beta-hexosaminidase, bacterial type, N-terminal	Domain
A	IPR049019	NagJ-like, helical domain	Domain
A	IPR036116	Fibronectin type III superfamily	Homologous Superfamily
B [auth T]	IPR015655	Protein phosphatase 2C	Family
B [auth T]	IPR001932	PPM-type phosphatase-like domain	Domain
B [auth T]	IPR036457	PPM-type phosphatase-like domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
B [auth T]	Pharos: Q15750	polycystic ovary syndrome atypical teratoid rhabdoid tumor inflammatory bowel disease malignant glioma primary biliary cholangitis Sjogren syndrome Crohn disease juvenile dermatomyositis osteosarcoma rheumatoid arthritis glioblastoma large cell medulloblastoma Sclerocystic Ovaries

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.