Annotations: 2Z63

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	LRR_8_3	e2z63A2	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8_3	ECOD (1.6)
A	LRR_8_1	e2z63A1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.80.10.10	Alpha Beta	Alpha-Beta Horseshoe	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	Ribonuclease Inhibitor	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF13855	Leucine rich repeat (LRR_8)	Leucine rich repeat	-	Repeat
A	PF13516	Leucine Rich repeat (LRR_6)	Leucine Rich repeat	-	Repeat
A	PF11921	Domain of unknown function (DUF3439) (DUF3439)	Domain of unknown function (DUF3439)	-	Family
A	PF12799	Leucine Rich repeats (2 copies) (LRR_4)	Leucine Rich repeats (2 copies)	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Toll-like receptor 4, Variable lymphocyte receptor B	amide binding amyloid-beta binding binding peptide binding hydrolase activity, acting on glycosyl bonds hydrolase activity NAD+ nucleotidase, cyclic ADP-ribose generating hydrolase activity, hydrolyzing N-glycosyl compounds catalytic activity molecular transducer activity transmembrane signaling receptor activity signaling receptor activity protein binding signaling receptor binding amide binding amyloid-beta binding binding peptide binding hydrolase activity, acting on glycosyl bonds hydrolase activity NAD+ nucleotidase, cyclic ADP-ribose generating hydrolase activity, hydrolyzing N-glycosyl compounds catalytic activity molecular transducer activity transmembrane signaling receptor activity signaling receptor activity protein binding signaling receptor binding lipid binding lipopolysaccharide binding carbohydrate derivative binding pattern recognition receptor activity lipopolysaccharide immune receptor activity identical protein binding protein heterodimerization activity protein dimerization activity	regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process metabolic process regulation of nitric oxide metabolic process regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process metabolic process regulation of nitric oxide metabolic process positive regulation of nitric oxide biosynthetic process regulation of metabolic process multicellular organismal process regulation of cellular process interleukin-1 production cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process regulation of cytokine production cytokine production positive regulation of interleukin-1 production regulation of multicellular organismal process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of interleukin-1 production cellular metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process cellular process macromolecule metabolic process positive regulation of cytokine production positive regulation of cellular biosynthetic process regulation of tumor necrosis factor production negative regulation of biological process negative regulation of cellular metabolic process negative regulation of tumor necrosis factor production negative regulation of cellular process negative regulation of macromolecule metabolic process negative regulation of metabolic process tumor necrosis factor superfamily cytokine production negative regulation of cytokine production tumor necrosis factor production negative regulation of cellular biosynthetic process negative regulation of gene expression regulation of tumor necrosis factor superfamily cytokine production negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of tumor necrosis factor superfamily cytokine production negative regulation of multicellular organismal process cellular response to stimulus cellular response to low-density lipoprotein particle stimulus cellular response to oxidised low-density lipoprotein particle stimulus response to stimulus response to endogenous stimulus response to chemical response to lipoprotein particle response to nitrogen compound cellular response to lipoprotein particle stimulus protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of protein localization transport matrix metallopeptidase secretion positive regulation of matrix metallopeptidase secretion positive regulation of establishment of protein localization positive regulation of secretion by cell protein localization to extracellular region positive regulation of protein transport localization secretion by cell regulation of secretion by cell positive regulation of secretion cellular macromolecule localization regulation of matrix metallopeptidase secretion secretion regulation of transport establishment of protein localization to extracellular region regulation of establishment of protein localization export from cell regulation of protein transport protein secretion establishment of localization positive regulation of protein secretion regulation of protein secretion regulation of secretion positive regulation of transport protein transport regulation of cellular localization macromolecule localization positive regulation of protein localization signaling negative regulation of signaling negative regulation of intracellular signal transduction regulation of signal transduction intracellular signal transduction negative regulation of cell communication cell communication regulation of intracellular signal transduction intracellular signaling cassette signal transduction regulation of signaling negative regulation of response to stimulus regulation of MAPK cascade negative regulation of signal transduction negative regulation of ERK1 and ERK2 cascade regulation of response to stimulus MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade negative regulation of MAPK cascade positive regulation of locomotion regulation of cell motility positive regulation of smooth muscle cell migration regulation of smooth muscle cell migration positive regulation of cell migration smooth muscle cell migration muscle cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion biological process involved in interspecies interaction between organisms response to other organism defense response response to external stimulus response to biotic stimulus defense response to bacterium defense response to other organism response to stress response to bacterium response to external biotic stimulus positive regulation of cell communication positive regulation of response to biotic stimulus positive regulation of signal transduction pattern recognition receptor signaling pathway immune response-activating signaling pathway positive regulation of immune response regulation of immune system process positive regulation of immune system process innate immune response-activating signaling pathway positive regulation of pattern recognition receptor signaling pathway immune response regulation of innate immune response positive regulation of intracellular signal transduction positive regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway regulation of pattern recognition receptor signaling pathway positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway cytoplasmic pattern recognition receptor signaling pathway regulation of defense response regulation of response to biotic stimulus regulation of response to external stimulus intracellular receptor signaling pathway regulation of cytoplasmic pattern recognition receptor signaling pathway positive regulation of response to stimulus positive regulation of response to external stimulus immune response-regulating signaling pathway regulation of response to stress innate immune response nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway nucleotide-binding oligomerization domain containing 2 signaling pathway positive regulation of innate immune response regulation of nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway defense response to symbiont positive regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway immune system process positive regulation of signaling positive regulation of interleukin-8 production interleukin-8 production regulation of interleukin-8 production regulation of chemokine production chemokine production positive regulation of chemokine production JNK cascade cellular response to lipoteichoic acid response to oxygen-containing compound response to lipoteichoic acid cellular response to molecule of bacterial origin cellular response to oxygen-containing compound cellular response to biotic stimulus cellular response to chemical stimulus response to molecule of bacterial origin interleukin-10 production regulation of interleukin-10 production positive regulation of interleukin-10 production cell population proliferation regulation of smooth muscle cell proliferation positive regulation of cell population proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation regulation of cell population proliferation muscle cell proliferation regulation of type II interferon production type II interferon production negative regulation of type II interferon production defense response to Gram-negative bacterium regulation of immune effector process regulation of cytokine production involved in immune response immune effector process regulation of macrophage cytokine production positive regulation of production of molecular mediator of immune response regulation of production of molecular mediator of immune response positive regulation of macrophage cytokine production positive regulation of myeloid leukocyte cytokine production involved in immune response positive regulation of immune effector process myeloid leukocyte cytokine production cytokine production involved in immune response production of molecular mediator of immune response positive regulation of cytokine production involved in immune response macrophage cytokine production system process epithelial structure maintenance homeostatic process digestive system process intestinal epithelial structure maintenance tissue homeostasis maintenance of gastrointestinal epithelium digestion multicellular organismal-level homeostasis anatomical structure homeostasis interleukin-17 production negative regulation of interleukin-17 production regulation of interleukin-17 production B cell proliferation involved in immune response B cell activation cell activation B cell proliferation B cell activation involved in immune response lymphocyte activation cell activation involved in immune response leukocyte proliferation leukocyte activation mononuclear cell proliferation leukocyte activation involved in immune response lymphocyte proliferation lymphocyte activation involved in immune response interferon-alpha production regulation of interferon-alpha production positive regulation of type I interferon production type I interferon production positive regulation of interferon-alpha production regulation of type I interferon production positive regulation of canonical NF-kappaB signal transduction canonical NF-kappaB signal transduction regulation of canonical NF-kappaB signal transduction regulation of macrophage activation positive regulation of macrophage activation regulation of leukocyte activation regulation of cell activation myeloid leukocyte activation macrophage activation positive regulation of cell activation positive regulation of leukocyte activation positive regulation of ERK1 and ERK2 cascade positive regulation of MAPK cascade regulation of programmed cell death extrinsic apoptotic signaling pathway positive regulation of apoptotic signaling pathway positive regulation of programmed cell death cell surface receptor signaling pathway regulation of apoptotic process positive regulation of extrinsic apoptotic signaling pathway cell death positive regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway apoptotic process programmed cell death regulation of apoptotic signaling pathway regulation of interleukin-12 production interleukin-12 production positive regulation of interleukin-12 production toll-like receptor signaling pathway TRIF-dependent toll-like receptor signaling pathway MyD88-independent toll-like receptor signaling pathway regulation of interferon-beta production interferon-beta production positive regulation of interferon-beta production developmental process myeloid leukocyte differentiation cellular developmental process hemopoiesis macrophage differentiation cell development mononuclear cell differentiation nervous system development multicellular organism development neurogenesis central nervous system development gliogenesis glial cell differentiation myeloid cell differentiation cell differentiation microglia differentiation anatomical structure development system development leukocyte differentiation positive regulation of phosphorylation regulation of catalytic activity regulation of transferase activity positive regulation of phosphate metabolic process regulation of MAP kinase activity regulation of primary metabolic process positive regulation of protein serine/threonine kinase activity regulation of phosphate metabolic process phosphate-containing compound metabolic process phosphorus metabolic process protein modification process positive regulation of protein phosphorylation positive regulation of MAP kinase activity protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process regulation of molecular function positive regulation of kinase activity regulation of kinase activity regulation of protein serine/threonine kinase activity macromolecule modification regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of molecular function positive regulation of protein modification process protein metabolic process positive regulation of protein kinase activity positive regulation of transferase activity positive regulation of catalytic activity regulation of protein kinase activity regulation of phosphorylation regulation of NLRP3 inflammasome complex assembly positive regulation of NLRP3 inflammasome complex assembly cellular component biogenesis cellular component assembly inflammasome-mediated signaling pathway canonical inflammasome complex assembly positive regulation of inflammasome-mediated signaling pathway regulation of inflammasome-mediated signaling pathway NLRP3 inflammasome complex assembly inflammatory response regulation of cellular component organization positive regulation of cellular component organization cellular component organization regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly protein-containing complex assembly cellular component organization or biogenesis protein-containing complex organization positive regulation of cellular component biogenesis regulation of cellular component biogenesis response to type II interferon response to cytokine cellular response to type II interferon response to peptide cellular response to cytokine stimulus response to mechanical stimulus response to abiotic stimulus cellular response to mechanical stimulus cellular response to abiotic stimulus cellular response to external stimulus cellular response to environmental stimulus regulation of non-canonical NF-kappaB signal transduction non-canonical NF-kappaB signal transduction positive regulation of non-canonical NF-kappaB signal transduction reactive oxygen species biosynthetic process positive regulation of reactive oxygen species biosynthetic process reactive oxygen species metabolic process regulation of reactive oxygen species biosynthetic process positive regulation of reactive oxygen species metabolic process regulation of reactive oxygen species metabolic process regulation of MHC class II biosynthetic process MHC class II biosynthetic process positive regulation of MHC class II biosynthetic process regulation of cytokine production involved in inflammatory response production of molecular mediator involved in inflammatory response cytokine production involved in inflammatory response positive regulation of cytokine production involved in inflammatory response regulation of body fluid levels positive regulation of platelet activation coagulation regulation of biological quality response to wounding wound healing hemostasis blood coagulation regulation of platelet activation platelet activation positive regulation of tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production negative regulation of cold-induced thermogenesis adaptive thermogenesis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis cellular response to nitrogen compound cellular response to amyloid-beta response to amyloid-beta response to lipid response to lipopolysaccharide positive regulation of type II interferon production regulation of cellular response to stress stress-activated MAPK cascade cellular response to stress positive regulation of stress-activated protein kinase signaling cascade positive regulation of stress-activated MAPK cascade regulation of stress-activated protein kinase signaling cascade regulation of stress-activated MAPK cascade stress-activated protein kinase signaling cascade MyD88-dependent toll-like receptor signaling pathway regulation of inflammatory response positive regulation of inflammatory response interleukin-6 production regulation of interleukin-6 production negative regulation of interleukin-6 production import into cell phagocytosis endocytosis vesicle-mediated transport interleukin-23 production regulation of interleukin-23 production negative regulation of interleukin-23 production nucleotide-binding oligomerization domain containing 1 signaling pathway regulation of leukocyte differentiation regulation of developmental process regulation of cell differentiation regulation of cell development regulation of osteoclast differentiation osteoclast differentiation negative regulation of cell differentiation negative regulation of hemopoiesis regulation of multicellular organismal development negative regulation of leukocyte differentiation regulation of myeloid cell differentiation negative regulation of developmental process regulation of myeloid leukocyte differentiation negative regulation of myeloid cell differentiation negative regulation of osteoclast differentiation negative regulation of myeloid leukocyte differentiation negative regulation of cell development negative regulation of immune system process regulation of hemopoiesis astrocyte differentiation glial cell development astrocyte development regulation of interleukin-1 beta production positive regulation of interleukin-1 beta production interleukin-1 beta production chemokine (C-X-C motif) ligand 2 production regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of chemokine (C-X-C motif) ligand 2 production positive regulation of JNK cascade regulation of JNK cascade positive regulation of DNA-binding transcription factor activity positive regulation of NF-kappaB transcription factor activity RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process nucleobase-containing compound biosynthetic process nucleic acid metabolic process regulation of DNA-binding transcription factor activity regulation of DNA-templated transcription wound healing involved in inflammatory response inflammatory response to wounding nitric oxide production involved in inflammatory response positive regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway regulation of nucleotide-binding oligomerization domain containing 1 signaling pathway positive regulation of B cell proliferation positive regulation of lymphocyte activation regulation of B cell proliferation regulation of B cell activation positive regulation of mononuclear cell proliferation regulation of lymphocyte proliferation regulation of leukocyte proliferation positive regulation of lymphocyte proliferation positive regulation of B cell activation positive regulation of leukocyte proliferation regulation of mononuclear cell proliferation regulation of lymphocyte activation positive regulation of DNA-templated transcription transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process detection of external biotic stimulus detection of lipopolysaccharide detection of molecule of bacterial origin detection of biotic stimulus detection of stimulus detection of chemical stimulus immune response-regulating cell surface receptor signaling pathway cell surface toll-like receptor signaling pathway immune response-activating cell surface receptor signaling pathway innate immune response activating cell surface receptor signaling pathway cell surface pattern recognition receptor signaling pathway toll-like receptor 4 signaling pathway cellular response to endogenous stimulus cellular response to growth factor stimulus cellular response to platelet-derived growth factor stimulus response to growth factor response to platelet-derived growth factor positive regulation of interleukin-6 production cellular response to lipopolysaccharide lipopolysaccharide-mediated signaling pathway cellular response to lipid regulation of nitric-oxide synthase biosynthetic process nitric-oxide synthase biosynthetic process positive regulation of nitric-oxide synthase biosynthetic process dendritic cell cytokine production regulation of dendritic cell cytokine production leukocyte mediated immunity regulation of leukocyte mediated immunity regulation of response to macrophage colony-stimulating factor response to macrophage colony-stimulating factor positive regulation of response to cytokine stimulus cellular response to macrophage colony-stimulating factor stimulus regulation of response to cytokine stimulus regulation of cellular response to macrophage colony-stimulating factor stimulus positive regulation of response to macrophage colony-stimulating factor positive regulation of cellular response to macrophage colony-stimulating factor stimulus detection of other organism response to fungus detection of fungus I-kappaB phosphorylation adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains T-helper 1 type immune response adaptive immune response	protein-containing complex receptor complex endosome membrane membrane-bounded organelle intracellular anatomical structure membrane endosome intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle protein-containing complex receptor complex endosome membrane membrane-bounded organelle intracellular anatomical structure membrane endosome intracellular vesicle cellular anatomical entity intracellular membrane-bounded organelle endomembrane system intracellular organelle cytoplasmic vesicle membrane bounding membrane of organelle vesicle membrane cytoplasmic vesicle organelle cytoplasm vesicle organelle membrane phagocytic cup cell periphery plasma membrane cell surface external side of plasma membrane side of membrane ruffle cell projection cell leading edge plasma membrane bounded cell projection perinuclear region of cytoplasm lipopolysaccharide receptor complex membrane protein complex early endosome

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR035897	Toll/interleukin-1 receptor homology (TIR) domain superfamily	Homologous Superfamily
A	IPR000483	Cysteine-rich flanking region, C-terminal	Domain
A	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain	Domain
A	IPR025875	Leucine rich repeat 4	Repeat
A	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
A	IPR001611	Leucine-rich repeat	Repeat
A	IPR017241	Toll-like receptor	Family
A	IPR003591	Leucine-rich repeat, typical subtype	Repeat
A	IPR050467	Leucine-rich repeat and fibronectin type-III domain-containing	Family
A	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
A	IPR000372	Leucine-rich repeat N-terminal domain	Domain
A	IPR024592	Variable lymphocyte receptor, C-terminal	Domain
A	IPR001611	Leucine-rich repeat	Repeat
A	IPR003591	Leucine-rich repeat, typical subtype	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O00206	hypertensive disorder pneumonia age-related macular degeneration contact dermatitis melanoma coronary artery disease esophageal adenocarcinoma Crohn disease atherosclerosis Behcet disease diabetic polyneuropathy Liver Cirrhosis, Experimental acute coronary syndrome hepatocellular carcinoma kidney failure hypertensive disorder pneumonia age-related macular degeneration contact dermatitis melanoma coronary artery disease esophageal adenocarcinoma Crohn disease atherosclerosis Behcet disease diabetic polyneuropathy Liver Cirrhosis, Experimental acute coronary syndrome hepatocellular carcinoma kidney failure perinatal necrotizing enterocolitis colorectal cancer ovarian cancer diabetic autonomic neuropathy diabetic neuropathy prostate cancer extrahepatic cholestasis carcinoma sarcomatoid carcinoma hearing loss disorder large cell medulloblastoma peripheral nervous system disease exocrine pancreatic carcinoma lung adenocarcinoma breast fibroadenoma lung carcinoma macular degeneration retinal degeneration Gaucher disease schizophrenia medulloblastoma IgA glomerulonephritis Crohn's colitis ulcerative colitis arthritic joint disease non-alcoholic fatty liver disease cutaneous melanoma osteosarcoma atypical teratoid rhabdoid tumor learning disability bipolar disorder peripheral neuropathy liver disease brain injury pneumonitis lung benign neoplasm cancer psoriasis cerebrovascular disorder gastric cancer acute kidney failure malignant glioma rheumatoid arthritis glioblastoma adrenal cortex carcinoma skin disease hypereosinophilic syndrome alcohol abuse ileocolitis undifferentiated carcinoma inflammatory bowel disease asthma non-small cell lung carcinoma cystic fibrosis ischemia reperfusion injury autoimmune disease periodontitis pilocytic astrocytoma endogenous depression lung cancer fatty liver disease gastric carcinoma malignant mesothelioma colorectal carcinoma age related macular degeneration 10 malignant pancreatic neoplasm allergic disease necrotizing enterocolitis type 2 diabetes mellitus inborn carbohydrate metabolic disorder arteriosclerosis disorder neurodegenerative disease influenza astrocytic tumor obesity disorder kidney disease ovarian neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.