Annotations: 3A79

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	LRR_8_3	e3a79A2	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8_3	ECOD (1.6)
A	LRR_8_1	e3a79A1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8_1	ECOD (1.6)
B	LRR_8_1	e3a79B4	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.80.10.10	Alpha Beta	Alpha-Beta Horseshoe	Leucine-rich repeat, LRR (right-handed beta-alpha superhelix)	Ribonuclease Inhibitor	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF13855	Leucine rich repeat (LRR_8)	Leucine rich repeat	-	Repeat
A	PF13516	Leucine Rich repeat (LRR_6)	Leucine Rich repeat	-	Repeat
A	PF11921	Domain of unknown function (DUF3439) (DUF3439)	Domain of unknown function (DUF3439)	-	Family
B	PF13855	Leucine rich repeat (LRR_8)	Leucine rich repeat	-	Repeat
B	PF11921	Domain of unknown function (DUF3439) (DUF3439)	Domain of unknown function (DUF3439)	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Toll-like receptor 2, Variable lymphocyte receptor B	amide binding amyloid-beta binding binding peptide binding diacyl lipopeptide binding lipid binding lipopeptide binding hydrolase activity, acting on glycosyl bonds hydrolase activity NAD+ nucleotidase, cyclic ADP-ribose generating hydrolase activity, hydrolyzing N-glycosyl compounds catalytic activity protein-containing complex binding molecular transducer activity amide binding amyloid-beta binding binding peptide binding diacyl lipopeptide binding lipid binding lipopeptide binding hydrolase activity, acting on glycosyl bonds hydrolase activity NAD+ nucleotidase, cyclic ADP-ribose generating hydrolase activity, hydrolyzing N-glycosyl compounds catalytic activity protein-containing complex binding molecular transducer activity transmembrane signaling receptor activity signaling receptor activity triacyl lipopeptide binding pattern recognition receptor activity carbohydrate derivative binding lipoteichoic acid binding	regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process cellular process regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process cellular process metabolic process regulation of nitric oxide metabolic process positive regulation of nitric oxide biosynthetic process regulation of metabolic process positive regulation of cellular process behavior multicellular organismal process system process learning learning or memory nervous system process cognition cellular response to stimulus regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms pattern recognition receptor signaling pathway response to stimulus regulation of response to external stimulus toll-like receptor signaling pathway signaling response to biotic stimulus cell communication positive regulation of response to stimulus immune response-activating signaling pathway positive regulation of response to external stimulus immune response-regulating signaling pathway positive regulation of immune response regulation of response to stress response to stress innate immune response regulation of immune system process response to external biotic stimulus signal transduction positive regulation of immune system process innate immune response-activating signaling pathway MyD88-dependent toll-like receptor signaling pathway positive regulation of innate immune response defense response immune response response to other organism regulation of innate immune response defense response to symbiont response to external stimulus regulation of response to stimulus immune system process defense response to other organism positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response regulation of inflammatory response positive regulation of inflammatory response inflammatory response catabolic process macroautophagy autophagy xenophagy process utilizing autophagic mechanism interleukin-1 production regulation of interleukin-1 beta production positive regulation of macromolecule biosynthetic process positive regulation of interleukin-1 beta production regulation of cytokine production cytokine production regulation of multicellular organismal process positive regulation of interleukin-1 production positive regulation of macromolecule metabolic process regulation of interleukin-1 production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of gene expression interleukin-1 beta production positive regulation of gene expression positive regulation of multicellular organismal process regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of cytokine production positive regulation of xenophagy regulation of autophagy positive regulation of macroautophagy positive regulation of autophagy regulation of xenophagy regulation of catabolic process positive regulation of catabolic process regulation of macroautophagy regulation of chemokine production chemokine production positive regulation of chemokine production positive regulation of cell communication regulation of signaling positive regulation of signal transduction positive regulation of intracellular signal transduction regulation of signal transduction intracellular signal transduction regulation of intracellular signal transduction regulation of cell communication positive regulation of signaling cellular response to lipoteichoic acid response to oxygen-containing compound response to lipoteichoic acid cellular response to molecule of bacterial origin cellular response to oxygen-containing compound cellular response to biotic stimulus cellular response to chemical stimulus response to bacterium response to chemical response to molecule of bacterial origin interleukin-10 production regulation of interleukin-10 production positive regulation of interleukin-10 production regulation of immune effector process positive regulation of myeloid leukocyte cytokine production involved in immune response positive regulation of immune effector process myeloid leukocyte cytokine production cytokine production involved in immune response production of molecular mediator of immune response regulation of cytokine production involved in immune response immune effector process regulation of macrophage cytokine production positive regulation of cytokine production involved in immune response positive regulation of production of molecular mediator of immune response regulation of production of molecular mediator of immune response positive regulation of macrophage cytokine production macrophage cytokine production negative regulation of biological process negative regulation of cellular process negative regulation of macromolecule metabolic process interleukin-17 production negative regulation of interleukin-17 production negative regulation of metabolic process negative regulation of cytokine production negative regulation of gene expression regulation of interleukin-17 production negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of multicellular organismal process positive regulation of DNA-templated transcription RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process primary metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription icosanoid metabolic process leukotriene metabolic process oxoacid metabolic process carboxylic acid metabolic process small molecule metabolic process organic acid metabolic process cell activation myeloid leukocyte activation leukocyte activation macrophage activation leukocyte activation involved in inflammatory response microglial cell activation glial cell activation neuroinflammatory response cellular response to bacterial lipoprotein response to bacterial lipoprotein response to bacterial lipopeptide cellular response to bacterial lipopeptide cellular response to triacyl bacterial lipopeptide response to triacyl bacterial lipopeptide response to molecule of fungal origin response to fungus cellular developmental process cellular component assembly involved in morphogenesis cell development glial cell development myelin assembly cellular component organization cellular component biogenesis multicellular organism development neurogenesis cellular anatomical entity morphogenesis cellular component assembly gliogenesis axon ensheathment ensheathment of neurons cell differentiation anatomical structure development cellular component organization or biogenesis system development developmental process oligodendrocyte development central nervous system myelination nervous system development central nervous system myelin formation myelination anatomical structure morphogenesis axon ensheathment in central nervous system central nervous system development oligodendrocyte differentiation glial cell differentiation anatomical structure formation involved in morphogenesis immune response-regulating cell surface receptor signaling pathway immune response-activating cell surface receptor signaling pathway innate immune response activating cell surface receptor signaling pathway cell surface pattern recognition receptor signaling pathway cell surface receptor signaling pathway myeloid leukocyte differentiation mononuclear cell differentiation microglia differentiation hemopoiesis macrophage differentiation microglia development myeloid cell differentiation myeloid cell development leukocyte differentiation cellular response to nitrogen compound cellular response to peptidoglycan response to nitrogen compound response to peptidoglycan positive regulation of ERK1 and ERK2 cascade intracellular signaling cassette positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of locomotion regulation of cell motility positive regulation of cell migration positive regulation of cell motility regulation of cell migration myeloid leukocyte migration cell migration cell motility locomotion regulation of leukocyte migration positive regulation of neutrophil migration positive regulation of leukocyte migration neutrophil migration granulocyte migration leukocyte migration regulation of locomotion regulation of neutrophil migration response to diacyl bacterial lipopeptide cellular response to diacyl bacterial lipopeptide interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production regulation of cellular component organization regulation of developmental process regulation of nervous system development negative regulation of cell junction assembly cell junction assembly negative regulation of nervous system development regulation of synapse structure or activity synapse organization regulation of biological quality regulation of synapse assembly regulation of multicellular organismal development negative regulation of cellular component organization negative regulation of developmental process negative regulation of synapse organization regulation of cellular component biogenesis regulation of cell junction assembly regulation of synapse organization cell junction organization synapse assembly negative regulation of synapse assembly detection of bacterial lipoprotein detection of external biotic stimulus detection of molecule of bacterial origin detection of biotic stimulus detection of bacterium detection of diacyl bacterial lipopeptide detection of stimulus detection of chemical stimulus detection of other organism detection of bacterial lipopeptide regulation of interleukin-12 production interleukin-12 production positive regulation of interleukin-12 production detection of triacyl bacterial lipopeptide regulation of interferon-beta production interferon-beta production positive regulation of type I interferon production type I interferon production positive regulation of interferon-beta production regulation of type I interferon production regulation of cytoskeleton organization regulation of actin filament-based process regulation of cellular component size regulation of protein-containing complex assembly protein-containing complex assembly actin filament-based process negative regulation of protein polymerization regulation of actin filament polymerization negative regulation of supramolecular fiber organization negative regulation of actin filament polymerization protein polymerization actin polymerization or depolymerization regulation of actin filament organization actin filament polymerization actin cytoskeleton organization protein-containing complex organization negative regulation of cytoskeleton organization actin filament organization regulation of actin polymerization or depolymerization regulation of organelle organization negative regulation of protein-containing complex assembly organelle organization negative regulation of organelle organization regulation of protein polymerization regulation of actin filament length regulation of actin cytoskeleton organization regulation of supramolecular fiber organization supramolecular fiber organization cytoskeleton organization regulation of anatomical structure size regulation of nitric-oxide synthase biosynthetic process positive regulation of nitric-oxide synthase biosynthetic process nitric-oxide synthase biosynthetic process dendritic cell cytokine production regulation of dendritic cell cytokine production leukocyte mediated immunity regulation of leukocyte mediated immunity negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation regulation of localization import into cell transport negative regulation of transport negative regulation of endocytosis vesicle-mediated transport localization negative regulation of phagocytosis phagocytosis regulation of endocytosis regulation of transport regulation of phagocytosis regulation of vesicle-mediated transport establishment of localization endocytosis negative regulation of interleukin-12 production response to lipid response to fatty acid positive regulation of nervous system development regulation of cell differentiation regulation of neurogenesis regulation of gliogenesis positive regulation of gliogenesis regulation of cell development positive regulation of developmental process positive regulation of cell differentiation positive regulation of neurogenesis positive regulation of oligodendrocyte differentiation regulation of glial cell differentiation positive regulation of cell development positive regulation of glial cell differentiation regulation of oligodendrocyte differentiation positive regulation of interleukin-18 production regulation of interleukin-18 production interleukin-18 production regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production defense response to Gram-positive bacterium defense response to bacterium	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle intracellular organelle phagocytic vesicle membrane cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane membrane-bounded organelle intracellular anatomical structure intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle intracellular organelle phagocytic vesicle membrane cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane organelle endocytic vesicle membrane cytoplasm vesicle organelle membrane endocytic vesicle Golgi apparatus endomembrane system protein-containing complex plasma membrane protein complex Toll-like receptor 2-Toll-like receptor 6 protein complex plasma membrane signaling receptor complex membrane protein complex receptor complex cell body Toll-like receptor 1-Toll-like receptor 2 protein complex membrane microdomain membrane raft cell projection
B	Toll-like receptor 6, Variable lymphocyte receptor B	molecular transducer activity signaling receptor activity amide binding diacyl lipopeptide binding binding lipid binding lipopeptide binding hydrolase activity, acting on glycosyl bonds hydrolase activity NAD+ nucleotidase, cyclic ADP-ribose generating hydrolase activity, hydrolyzing N-glycosyl compounds catalytic activity protein binding Toll-like receptor 2 binding molecular transducer activity signaling receptor activity amide binding diacyl lipopeptide binding binding lipid binding lipopeptide binding hydrolase activity, acting on glycosyl bonds hydrolase activity NAD+ nucleotidase, cyclic ADP-ribose generating hydrolase activity, hydrolyzing N-glycosyl compounds catalytic activity protein binding Toll-like receptor 2 binding signaling receptor binding Toll-like receptor binding identical protein binding transmembrane signaling receptor activity	positive regulation of nervous system development multicellular organismal process positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization regulation of developmental process positive regulation of biological process regulation of nervous system development positive regulation of developmental process cellular component organization cellular component biogenesis multicellular organism development cellular component assembly cell junction assembly anatomical structure development positive regulation of nervous system development multicellular organismal process positive regulation of cellular component organization regulation of cellular process regulation of cellular component organization regulation of developmental process positive regulation of biological process regulation of nervous system development positive regulation of developmental process cellular component organization cellular component biogenesis multicellular organism development cellular component assembly cell junction assembly anatomical structure development regulation of multicellular organismal process regulation of synapse structure or activity synapse organization cellular component organization or biogenesis regulation of synapse assembly regulation of biological quality positive regulation of cellular process system development developmental process regulation of multicellular organismal development regulation of biological process positive regulation of cellular component biogenesis biological regulation nervous system development regulation of cellular component biogenesis regulation of cell junction assembly positive regulation of cell junction assembly regulation of synapse organization cell junction organization positive regulation of multicellular organismal process cellular process synapse assembly positive regulation of synapse assembly axonogenesis cellular developmental process cell projection organization plasma membrane bounded cell projection morphogenesis cell development neuron projection development cell morphogenesis neurogenesis cell projection morphogenesis neuron differentiation neuron projection morphogenesis cell differentiation plasma membrane bounded cell projection organization axon development cell morphogenesis involved in neuron differentiation generation of neurons anatomical structure morphogenesis neuron development regulation of presynapse assembly regulation of presynapse organization presynapse organization presynapse assembly regulation of biosynthetic process regulation of nitric oxide biosynthetic process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process metabolic process regulation of nitric oxide metabolic process positive regulation of nitric oxide biosynthetic process regulation of metabolic process cellular response to stimulus positive regulation of cell communication positive regulation of signal transduction positive regulation of canonical NF-kappaB signal transduction response to stimulus signaling regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction regulation of signaling positive regulation of intracellular signal transduction canonical NF-kappaB signal transduction regulation of response to stimulus regulation of cell communication regulation of canonical NF-kappaB signal transduction positive regulation of signaling regulation of macrophage activation positive regulation of macrophage activation regulation of leukocyte activation cell activation regulation of cell activation myeloid leukocyte activation leukocyte activation macrophage activation positive regulation of cell activation immune system process positive regulation of leukocyte activation regulation of immune system process positive regulation of immune system process regulation of tumor necrosis factor production negative regulation of biological process negative regulation of tumor necrosis factor production cytokine production regulation of cytokine production negative regulation of cellular process negative regulation of macromolecule metabolic process negative regulation of metabolic process tumor necrosis factor superfamily cytokine production negative regulation of cytokine production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process tumor necrosis factor production regulation of gene expression negative regulation of gene expression regulation of tumor necrosis factor superfamily cytokine production negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of tumor necrosis factor superfamily cytokine production regulation of macromolecule biosynthetic process macromolecule metabolic process negative regulation of multicellular organismal process regulation of defense response positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms pattern recognition receptor signaling pathway regulation of response to external stimulus toll-like receptor signaling pathway response to biotic stimulus immune response-activating signaling pathway positive regulation of response to external stimulus immune response-regulating signaling pathway positive regulation of immune response regulation of response to stress response to stress innate immune response response to external biotic stimulus innate immune response-activating signaling pathway MyD88-dependent toll-like receptor signaling pathway positive regulation of innate immune response defense response immune response response to other organism regulation of innate immune response defense response to symbiont response to external stimulus defense response to other organism positive regulation of defense response activation of innate immune response regulation of immune response activation of immune response regulation of inflammatory response positive regulation of inflammatory response inflammatory response cellular response to low-density lipoprotein particle stimulus cellular response to oxidised low-density lipoprotein particle stimulus response to endogenous stimulus response to chemical response to lipoprotein particle response to nitrogen compound cellular response to lipoprotein particle stimulus cellular response to bacterial lipoprotein response to diacyl bacterial lipopeptide cellular response to molecule of bacterial origin cellular response to diacyl bacterial lipopeptide response to bacterial lipoprotein response to bacterial lipopeptide cellular response to biotic stimulus cellular response to bacterial lipopeptide response to bacterium response to molecule of bacterial origin positive regulation of macromolecule biosynthetic process positive regulation of gene expression positive regulation of macromolecule metabolic process interleukin-6 production positive regulation of interleukin-6 production regulation of interleukin-6 production positive regulation of cytokine production detection of bacterial lipoprotein detection of external biotic stimulus detection of molecule of bacterial origin detection of biotic stimulus detection of bacterium detection of diacyl bacterial lipopeptide detection of stimulus detection of chemical stimulus detection of other organism detection of bacterial lipopeptide regulation of programmed cell death extrinsic apoptotic signaling pathway positive regulation of apoptotic signaling pathway positive regulation of programmed cell death cell surface receptor signaling pathway regulation of apoptotic process positive regulation of extrinsic apoptotic signaling pathway cell death positive regulation of apoptotic process regulation of extrinsic apoptotic signaling pathway apoptotic signaling pathway apoptotic process programmed cell death regulation of apoptotic signaling pathway regulation of interleukin-12 production interleukin-12 production positive regulation of interleukin-12 production TRIF-dependent toll-like receptor signaling pathway MyD88-independent toll-like receptor signaling pathway interleukin-1 production regulation of interleukin-1 beta production positive regulation of interleukin-1 beta production positive regulation of interleukin-1 production regulation of interleukin-1 production interleukin-1 beta production regulation of NLRP3 inflammasome complex assembly positive regulation of NLRP3 inflammasome complex assembly inflammasome-mediated signaling pathway canonical inflammasome complex assembly positive regulation of pattern recognition receptor signaling pathway positive regulation of inflammasome-mediated signaling pathway regulation of inflammasome-mediated signaling pathway regulation of pattern recognition receptor signaling pathway NLRP3 inflammasome complex assembly cytoplasmic pattern recognition receptor signaling pathway intracellular receptor signaling pathway regulation of cytoplasmic pattern recognition receptor signaling pathway regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly protein-containing complex assembly protein-containing complex organization reactive oxygen species biosynthetic process positive regulation of reactive oxygen species biosynthetic process reactive oxygen species metabolic process regulation of reactive oxygen species biosynthetic process positive regulation of reactive oxygen species metabolic process regulation of reactive oxygen species metabolic process regulation of cytokine production involved in inflammatory response production of molecular mediator involved in inflammatory response cytokine production involved in inflammatory response positive regulation of cytokine production involved in inflammatory response leukocyte activation involved in inflammatory response microglial cell activation glial cell activation neuroinflammatory response	cellular anatomical structure membrane cell periphery plasma membrane membrane microdomain membrane raft membrane-bounded organelle intracellular anatomical structure intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle intracellular organelle phagocytic vesicle membrane cytoplasmic vesicle membrane cellular anatomical structure membrane cell periphery plasma membrane membrane microdomain membrane raft membrane-bounded organelle intracellular anatomical structure intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle intracellular organelle phagocytic vesicle membrane cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane organelle endocytic vesicle membrane cytoplasm vesicle organelle membrane endocytic vesicle Golgi apparatus endomembrane system protein-containing complex plasma membrane protein complex Toll-like receptor 2-Toll-like receptor 6 protein complex plasma membrane signaling receptor complex membrane protein complex receptor complex
C	Pam2CSK4	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001611	Leucine-rich repeat	Repeat
A	IPR017241	Toll-like receptor	Family
A	IPR035897	Toll/interleukin-1 receptor homology (TIR) domain superfamily	Homologous Superfamily
A	IPR000483	Cysteine-rich flanking region, C-terminal	Domain
A	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain	Domain
A	IPR003591	Leucine-rich repeat, typical subtype	Repeat
A	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
A	IPR050467	Leucine-rich repeat and fibronectin type-III domain-containing	Family
A	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
A	IPR000372	Leucine-rich repeat N-terminal domain	Domain
A	IPR024592	Variable lymphocyte receptor, C-terminal	Domain
A	IPR001611	Leucine-rich repeat	Repeat
A	IPR003591	Leucine-rich repeat, typical subtype	Repeat
B	IPR025875	Leucine rich repeat 4	Repeat
B	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
B	IPR000372	Leucine-rich repeat N-terminal domain	Domain
B	IPR043326	Slitrk	Unknown
B	IPR024592	Variable lymphocyte receptor, C-terminal	Domain
B	IPR001611	Leucine-rich repeat	Repeat
B	IPR003591	Leucine-rich repeat, typical subtype	Repeat
B	IPR000157	Toll/interleukin-1 receptor homology (TIR) domain	Domain
B	IPR003591	Leucine-rich repeat, typical subtype	Repeat
B	IPR001611	Leucine-rich repeat	Repeat
B	IPR017241	Toll-like receptor	Family
B	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
B	IPR035897	Toll/interleukin-1 receptor homology (TIR) domain superfamily	Homologous Superfamily
B	IPR000483	Cysteine-rich flanking region, C-terminal	Domain