Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad3amza2 All alpha proteins CO dehydrogenase ISP C-domain like CO dehydrogenase ISP C-domain like CO dehydrogenase ISP C-domain like Xanthine oxidase, domain 2 (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Ad3amza1 Alpha and beta proteins (a+b) beta-Grasp (ubiquitin-like) 2Fe-2S ferredoxin-like 2Fe-2S ferredoxin domains from multidomain proteins Xanthine oxidase, N-terminal domain (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Ad3amza5 Alpha and beta proteins (a+b) alpha/beta-Hammerhead CO dehydrogenase molybdoprotein N-domain-like CO dehydrogenase molybdoprotein N-domain-like Xanthine oxidase, domain 5 (?) (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Ad3amza4 Alpha and beta proteins (a+b) CO dehydrogenase flavoprotein C-domain-like CO dehydrogenase flavoprotein C-terminal domain-like CO dehydrogenase flavoprotein C-terminal domain-like Xanthine oxidase, domain 4 (?) (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Ad3amza6 Alpha and beta proteins (a+b) Molybdenum cofactor-binding domain Molybdenum cofactor-binding domain Molybdenum cofactor-binding domain Xanthine oxidase, C-terminal domain (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Ad3amza3 Alpha and beta proteins (a+b) FAD-binding/transporter-associated domain-like FAD-binding/transporter-associated domain-like CO dehydrogenase flavoprotein N-terminal domain-like Xanthine oxidase, domain 3 (?) (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Bd3amzb2 All alpha proteins CO dehydrogenase ISP C-domain like CO dehydrogenase ISP C-domain like CO dehydrogenase ISP C-domain like Xanthine oxidase, domain 2 (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Bd3amzb1 Alpha and beta proteins (a+b) beta-Grasp (ubiquitin-like) 2Fe-2S ferredoxin-like 2Fe-2S ferredoxin domains from multidomain proteins Xanthine oxidase, N-terminal domain (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Bd3amzb5 Alpha and beta proteins (a+b) alpha/beta-Hammerhead CO dehydrogenase molybdoprotein N-domain-like CO dehydrogenase molybdoprotein N-domain-like Xanthine oxidase, domain 5 (?) (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Bd3amzb4 Alpha and beta proteins (a+b) CO dehydrogenase flavoprotein C-domain-like CO dehydrogenase flavoprotein C-terminal domain-like CO dehydrogenase flavoprotein C-terminal domain-like Xanthine oxidase, domain 4 (?) (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Bd3amzb6 Alpha and beta proteins (a+b) Molybdenum cofactor-binding domain Molybdenum cofactor-binding domain Molybdenum cofactor-binding domain Xanthine oxidase, C-terminal domain (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)
Bd3amzb3 Alpha and beta proteins (a+b) FAD-binding/transporter-associated domain-like FAD-binding/transporter-associated domain-like CO dehydrogenase flavoprotein N-terminal domain-like Xanthine oxidase, domain 3 (?) (Bos taurus ) [TaxId: 9913 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyCO dehydrogenase flavoprotein C-terminal domain-like 8043061 3001921 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyCO dehydrogenase molybdoprotein N-domain-like 8043059 3000847 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyFAD-binding/transporter-associated domain-like 8043065 3000913 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyMolybdenum cofactor-binding domain 8043062 3000625 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyCO dehydrogenase ISP C-domain like 8043057 3000439 SCOP2B (2022-06-29)
ASCOP2B Superfamily2Fe-2S ferredoxin-like 8043058 3000113 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyCO dehydrogenase ISP C-domain like 8043057 3000439 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyCO dehydrogenase flavoprotein C-terminal domain-like 8043061 3001921 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyFAD-binding/transporter-associated domain-like 8043065 3000913 SCOP2B (2022-06-29)
BSCOP2B Superfamily2Fe-2S ferredoxin-like 8043058 3000113 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyCO dehydrogenase molybdoprotein N-domain-like 8043059 3000847 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyMolybdenum cofactor-binding domain 8043062 3000625 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AFer2_2e3amzA6 A: alpha bundlesX: CO dehydrogenase ISP C-domain like (From Topology)H: CO dehydrogenase ISP C-domain like (From Topology)T: CO dehydrogenase ISP C-domain likeF: Fer2_2ECOD (1.6)
AFer2e3amzA5 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Ubiquitin-likeF: Fer2ECOD (1.6)
AAld_Xan_dh_C2e3amzA7 A: a+b two layersX: MocoBD/DmpA-related (From Homology)H: MocoBD/DmpA-relatedT: Molybdenum cofactor-binding domainF: Ald_Xan_dh_C2ECOD (1.6)
ACO_deh_flav_Ce3amzA4 A: a+b two layersX: FAD-linked reductases, C-terminal domain-likeH: SufE/NifU (From Topology)T: SufE/NifUF: CO_deh_flav_CECOD (1.6)
AFAD_binding_5e3amzA2 A: a+b complex topologyX: FAD-binding domain-likeH: FAD-binding domain (From Topology)T: FAD-binding domainF: FAD_binding_5ECOD (1.6)
AAld_Xan_dh_Ce3amzA11 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: alpha/beta-Hammerhead/Barrel-sandwich hybridT: CO dehydrogenase molybdoprotein N-domain-likeF: Ald_Xan_dh_CECOD (1.6)
BFer2_2e3amzB6 A: alpha bundlesX: CO dehydrogenase ISP C-domain like (From Topology)H: CO dehydrogenase ISP C-domain like (From Topology)T: CO dehydrogenase ISP C-domain likeF: Fer2_2ECOD (1.6)
BFer2e3amzB5 A: a+b two layersX: beta-GraspH: Ubiquitin-relatedT: Ubiquitin-likeF: Fer2ECOD (1.6)
BAld_Xan_dh_C2e3amzB4 A: a+b two layersX: MocoBD/DmpA-related (From Homology)H: MocoBD/DmpA-relatedT: Molybdenum cofactor-binding domainF: Ald_Xan_dh_C2ECOD (1.6)
BCO_deh_flav_Ce3amzB17 A: a+b two layersX: FAD-linked reductases, C-terminal domain-likeH: SufE/NifU (From Topology)T: SufE/NifUF: CO_deh_flav_CECOD (1.6)
BFAD_binding_5e3amzB2 A: a+b complex topologyX: FAD-binding domain-likeH: FAD-binding domain (From Topology)T: FAD-binding domainF: FAD_binding_5ECOD (1.6)
BAld_Xan_dh_Ce3amzB16 A: a+b complex topologyX: alpha/beta-Hammerhead/Barrel-sandwich hybridH: alpha/beta-Hammerhead/Barrel-sandwich hybridT: CO dehydrogenase molybdoprotein N-domain-likeF: Ald_Xan_dh_CECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF00941FAD binding domain in molybdopterin dehydrogenase (FAD_binding_5)FAD binding domain in molybdopterin dehydrogenase- Family
A, B
PF01315Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain (Ald_Xan_dh_C)Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain- Domain
A, B
PF01799[2Fe-2S] binding domain (Fer2_2)[2Fe-2S] binding domain- Domain
A, B
PF20256Molybdopterin cofactor-binding domain (MoCoBD_2)Molybdopterin cofactor-binding domain- Domain
A, B
PF03450CO dehydrogenase flavoprotein C-terminal domain (CO_deh_flav_C)CO dehydrogenase flavoprotein C-terminal domain- Domain
A, B
PF02738Molybdopterin cofactor-binding domain (MoCoBD_1)Molybdopterin cofactor-binding domain- Domain
A, B
PF001112Fe-2S iron-sulfur cluster binding domain (Fer2)2Fe-2S iron-sulfur cluster binding domain- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
Xanthine dehydrogenase/oxidase

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B
IPR016167FAD-binding, type PCMH, subdomain 1Homologous Superfamily
A, B
IPR0010412Fe-2S ferredoxin-type iron-sulfur binding domainDomain
A, B
IPR0060582Fe-2S ferredoxin, iron-sulphur binding siteBinding Site
A, B
IPR046867Aldehyde oxidase/xanthine dehydrogenase, second molybdopterin binding domainDomain
A, B
IPR002888[2Fe-2S]-bindingDomain
A, B
IPR036318FAD-binding, type PCMH-like superfamilyHomologous Superfamily
A, B
IPR016208Aldehyde oxidase/xanthine dehydrogenase-likeFamily
A, B
IPR012675Beta-grasp domain superfamilyHomologous Superfamily
A, B
IPR036683CO dehydrogenase flavoprotein, C-terminal domain superfamilyHomologous Superfamily
A, B
IPR0360102Fe-2S ferredoxin-like superfamilyHomologous Superfamily
A, B
IPR000674Aldehyde oxidase/xanthine dehydrogenase, a/b hammerheadDomain
A, B
IPR022407Oxidoreductase, molybdopterin binding siteBinding Site
A, B
IPR036856Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamilyHomologous Superfamily
A, B
IPR037165Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamilyHomologous Superfamily
A, B
IPR016166FAD-binding domain, PCMH-typeDomain
A, B
IPR002346Molybdopterin dehydrogenase, FAD-bindingDomain
A, B
IPR014307Xanthine dehydrogenase, small subunitDomain
A, B
IPR016169FAD-binding, type PCMH, subdomain 2Homologous Superfamily
A, B
IPR036884[2Fe-2S]-binding domain superfamilyHomologous Superfamily
A, B
IPR008274Aldehyde oxidase/xanthine dehydrogenase, first molybdopterin binding domainDomain
A, B
IPR005107CO dehydrogenase flavoprotein, C-terminalDomain

Structure Motif Annotation: Mechanism and Catalytic Site Atlas M-CSA Database Homepage

ChainsEnzyme NameDescriptionCatalytic Residues
xanthine oxidase  M-CSA #987

Xanthine oxidase (XO) is a homodimer enzyme that gives its name to the xanthine oxidase structural family. XO catalyses the conversion of xanthine (XAN) to uric acid (URC) using a molybdenum cofactor (Moco). This is the last step of purine nucleotide catabolism in humans as well as primates, birds, reptiles and insects.

Xanthine oxidase comes from the same gene product as xanthine dehydrogenase (XDH) (EC 1.17.1.4 - M-CSA ID:139). XO and XDH share the same basic mechanism but differ in regeneration of the cofactor. Unlike XDH, XO does not use NAD+ as an oxidising substrate and instead uses O2.
The enzyme is of interest due to its relationship with certain diseases. For example, gout and uric acid stone formation are caused by intense activity of xanthine oxidase. Also, xanthinuria is a rare genetic disorder associated with low xanthine oxidase activity.

Defined by 3 residues: GLU:A-802ARG:A-880GLU:A-1261
 | 
 
Explore in 3DM-CSA Motif Definition