3AP2

Crystal structure of human tyrosylprotein sulfotransferase-2 complexed with PAP,C4 peptide, and phosphate ion

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	P-loop nucleotide/nucleoside kinase-like	8105338	3002021	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	P-loop nucleotide/nucleoside kinase-like	8105338	3002021	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Sulfotransfer_1	e3ap2A1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Sulfotransfer_1	ECOD (1.6)
B	Sulfotransfer_1	e3ap2B1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Sulfotransfer_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
B	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF13469	Sulfotransferase family (Sulfotransfer_3)	Sulfotransferase family	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Protein-tyrosine sulfotransferase 2	identical protein binding protein binding binding protein homodimerization activity protein dimerization activity catalytic activity, acting on a protein transferase activity, transferring sulphur-containing groups sulfotransferase activity transferase activity catalytic activity protein-tyrosine sulfotransferase activity	ribose phosphate metabolic process nucleoside bisphosphate metabolic process purine nucleoside bisphosphate metabolic process ribonucleoside bisphosphate metabolic process oxoacid metabolic process carbohydrate derivative metabolic process organic acid metabolic process purine ribonucleoside bisphosphate metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process small molecule metabolic process ribose phosphate metabolic process nucleoside bisphosphate metabolic process purine nucleoside bisphosphate metabolic process ribonucleoside bisphosphate metabolic process oxoacid metabolic process carbohydrate derivative metabolic process organic acid metabolic process purine ribonucleoside bisphosphate metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process ribonucleotide metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process small molecule metabolic process sulfur compound metabolic process phosphorus metabolic process nucleoside phosphate metabolic process 3'-phosphoadenosine 5'-phosphosulfate metabolic process cellular metabolic process primary metabolic process nucleotide metabolic process purine-containing compound metabolic process organophosphate metabolic process metabolic process cellular process purine ribonucleotide metabolic process peptidyl-tyrosine sulfation peptidyl-tyrosine modification sulfation protein sulfation macromolecule modification peptidyl-amino acid modification protein metabolic process macromolecule metabolic process protein modification process	membrane-bounded organelle intracellular organelle intracellular anatomical structure Golgi apparatus organelle cytoplasm cellular anatomical entity intracellular membrane-bounded organelle endomembrane system Golgi membrane membrane bounding membrane of organelle organelle membrane endoplasmic reticulum
C [auth S], D [auth T]	C4 peptide	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR026634	Protein-tyrosine sulfotransferase-like	Family
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: O60704	atypical teratoid rhabdoid tumor large cell medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma pituitary cancer subependymal giant cell astrocytoma cystic fibrosis malignant pancreatic neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor tuberculosis invasive ductal breast carcinoma medulloblastoma pancreatic ductal adenocarcinoma atypical teratoid rhabdoid tumor large cell medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma pituitary cancer subependymal giant cell astrocytoma cystic fibrosis malignant pancreatic neoplasm ovarian cancer pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor tuberculosis invasive ductal breast carcinoma medulloblastoma pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Sjogren syndrome ulcerative colitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.