Annotations: 3B2D

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C	E1_DerP2_DerF2	e3b2dC1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: E1_DerP2_DerF2	ECOD (1.6)
D	E1_DerP2_DerF2	e3b2dD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: E1_DerP2_DerF2	ECOD (1.6)
A	LRR_8	e3b2dA1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8	ECOD (1.6)
B	LRR_8_3	e3b2dB1	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8_3	ECOD (1.6)
B	LRR_8	e3b2dB2	A: beta duplicates or obligate multimers	X: Single-stranded right-handed beta-helix	H: Leucine-rich repeats (From Topology)	T: Leucine-rich repeats	F: LRR_8	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C	2.60.40.770	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
D	2.60.40.770	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
C, D	PF02221	ML domain (E1_DerP2_DerF2)	ML domain	ML domain - MD-2-related lipid recognition domain. This family consists of proteins from plants, animals and fungi, including dust mite allergen Der P 2 (Swiss:P49278). It has been implicate in lipid recognition, particularly in the recognition of pa ...	ML domain - MD-2-related lipid recognition domain. This family consists of proteins from plants, animals and fungi, including dust mite allergen Der P 2 (Swiss:P49278). It has been implicate in lipid recognition, particularly in the recognition of pathogen related products. A mutation in Npc2 (Swiss:Q15668) causes a rare form of Niemann-Pick type C2 disease. This domain has a similar topology to immunoglobulin domains.	Domain
A, B	PF13855	Leucine rich repeat (LRR_8)	Leucine rich repeat	-	Repeat
A, B	PF18831	Leucine-rich repeat (LRR_11)	Leucine-rich repeat	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
C, D	Lymphocyte antigen 86	-	cellular response to stimulus biological process involved in interspecies interaction between organisms regulation of cellular process response to lipid response to stimulus signaling cellular response to lipopolysaccharide response to biotic stimulus cell communication lipopolysaccharide-mediated signaling pathway cellular response to biotic stimulus response to bacterium response to external biotic stimulus signal transduction cellular response to stimulus biological process involved in interspecies interaction between organisms regulation of cellular process response to lipid response to stimulus signaling cellular response to lipopolysaccharide response to biotic stimulus cell communication lipopolysaccharide-mediated signaling pathway cellular response to biotic stimulus response to bacterium response to external biotic stimulus signal transduction regulation of biological process cell surface receptor signaling pathway response to other organism biological regulation response to oxygen-containing compound response to external stimulus cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound cellular response to chemical stimulus response to chemical cellular response to lipid cellular process response to molecule of bacterial origin defense response response to stress inflammatory response immune response defense response to symbiont immune system process defense response to other organism innate immune response positive regulation of cell communication regulation of lipopolysaccharide-mediated signaling pathway positive regulation of response to biotic stimulus regulation of response to biotic stimulus positive regulation of signal transduction regulation of response to external stimulus positive regulation of biological process regulation of signal transduction positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of cellular process regulation of signaling regulation of response to stimulus regulation of cell communication positive regulation of lipopolysaccharide-mediated signaling pathway positive regulation of signaling	extracellular region cellular anatomical entity
A, B	CD180 antigen	-	cellular response to stimulus positive regulation of cell communication regulation of lipopolysaccharide-mediated signaling pathway positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of cellular process positive regulation of signal transduction response to stimulus response to lipid regulation of response to external stimulus signaling cellular response to lipopolysaccharide positive regulation of biological process regulation of signal transduction cellular response to stimulus positive regulation of cell communication regulation of lipopolysaccharide-mediated signaling pathway positive regulation of response to biotic stimulus regulation of response to biotic stimulus biological process involved in interspecies interaction between organisms regulation of cellular process positive regulation of signal transduction response to stimulus response to lipid regulation of response to external stimulus signaling cellular response to lipopolysaccharide positive regulation of biological process regulation of signal transduction response to biotic stimulus cell communication positive regulation of response to stimulus lipopolysaccharide-mediated signaling pathway cellular response to biotic stimulus positive regulation of response to external stimulus response to bacterium response to external biotic stimulus signal transduction positive regulation of cellular process regulation of biological process regulation of signaling cell surface receptor signaling pathway response to other organism biological regulation response to oxygen-containing compound response to external stimulus cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound cellular response to chemical stimulus regulation of response to stimulus response to chemical cellular response to lipid regulation of cell communication cellular process positive regulation of lipopolysaccharide-mediated signaling pathway response to molecule of bacterial origin positive regulation of signaling defense response response to stress inflammatory response immune response defense response to symbiont immune system process defense response to other organism innate immune response multicellular organismal process B cell proliferation involved in immune response cell population proliferation B cell activation cell activation B cell proliferation B cell activation involved in immune response lymphocyte activation cell activation involved in immune response leukocyte proliferation leukocyte activation immune effector process mononuclear cell proliferation leukocyte activation involved in immune response lymphocyte proliferation lymphocyte activation involved in immune response	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle cellular anatomical entity nucleolus intracellular organelle lumen intracellular organelle organelle lumen organelle intracellular non-membrane-bounded organelle nuclear lumen non-membrane-bounded organelle cell periphery plasma membrane membrane extracellular matrix external encapsulating structure mitotic spindle cytoskeleton spindle microtubule cytoskeleton extracellular region extracellular space nucleoplasm

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
C, D	IPR039945	Lymphocyte antigen 86	Family
C, D	IPR014756	Immunoglobulin E-set	Homologous Superfamily
C, D	IPR003172	MD-2-related lipid-recognition domain	Domain
A, B	IPR001611	Leucine-rich repeat	Repeat
A, B	IPR050328	Multifunctional Developmental and Immune Receptor	Family
A, B	IPR003591	Leucine-rich repeat, typical subtype	Repeat
A, B	IPR032675	Leucine-rich repeat domain superfamily	Homologous Superfamily
A, B	IPR000483	Cysteine-rich flanking region, C-terminal	Domain
A, B	IPR041281	CD180, leucine-rich repeat	Repeat

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
C, D	Pharos: O95711	heart valve disease calcinosis Liver Cirrhosis, Experimental pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma tuberculosis adrenal cortex carcinoma endogenous depression invasive ductal breast carcinoma lung carcinoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm Sjogren syndrome astrocytic tumor endometriosis heart valve disease calcinosis Liver Cirrhosis, Experimental pancreatic intraductal papillary-mucinous carcinoma pilocytic astrocytoma tuberculosis adrenal cortex carcinoma endogenous depression invasive ductal breast carcinoma lung carcinoma non-small cell lung carcinoma pancreatic intraductal papillary-mucinous neoplasm Sjogren syndrome astrocytic tumor endometriosis medulloblastoma osteosarcoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia subependymal giant cell astrocytoma vascular disease B-cell chronic lymphocytic leukemia brain injury cutaneous lupus erythematosus glioblastoma interstitial cystitis lung cancer
A, B	Pharos: Q99467	cutaneous lupus erythematosus non-small cell lung carcinoma interstitial cystitis osteosarcoma lung adenocarcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.