3BUM

Crystal structure of c-Cbl-TKB domain complexed with its binding motif in Sprouty2

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations
Protein Modification Annotation

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d3bumb1	All alpha proteins	EF Hand-like	EF-hand	EF-hand modules in multidomain proteins	Cbl	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3bumb2	All alpha proteins	N-cbl like	N-terminal domain of cbl (N-cbl)	N-terminal domain of cbl (N-cbl)	N-terminal domain of cbl (N-cbl)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3bumb3	Alpha and beta proteins (a+b)	SH2-like	SH2 domain	SH2 domain	Cbl	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	EF-hand	8039549	3001983	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	N-terminal domain of cbl (N-cbl)	8039550	3000373	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	SH2 domain	8039553	3000197	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	Cbl_N2	e3bumB1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: Cbl_N2	ECOD (1.6)
B	Cbl_N	e3bumB2	A: alpha bundles	X: N-cbl like	H: N-terminal domain of cbl (N-cbl) (From Topology)	T: N-terminal domain of cbl (N-cbl)	F: Cbl_N	ECOD (1.6)
B	Cbl_N3	e3bumB3	A: a+b two layers	X: SH2 (From Topology)	H: SH2 (From Topology)	T: SH2	F: Cbl_N3	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	1.20.930.20	Mainly Alpha	Up-down Bundle	Transcription Elongation Factor S-II	Chain A	CATH (4.3.0)
B	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
B	3.30.505.10	Alpha Beta	2-Layer Sandwich	SHC Adaptor Protein	SH2 domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B	PF02262	CBL proto-oncogene N-terminal domain 1 (Cbl_N)	CBL proto-oncogene N-terminal domain 1	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated ...	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. Cbl_N is comprised of 3 structural domains of which this is the first - a four helix bundle.	Domain
B	PF02762	CBL proto-oncogene N-terminus, SH2-like domain (Cbl_N3)	CBL proto-oncogene N-terminus, SH2-like domain	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated ...	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. The so called N-terminal domain is actually 3 structural domains, of which this is the C-terminal SH2 domain.	Domain
B	PF02761	CBL proto-oncogene N-terminus, EF hand-like domain (Cbl_N2)	CBL proto-oncogene N-terminus, EF hand-like domain	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated ...	Cbl is an adaptor protein that binds EGF receptors (or other tyrosine kinases) and SH3 domains, functioning as a negative regulator of many signaling pathways. The N-terminal domain is evolutionarily conserved, and is known to bind to phosphorylated tyrosine residues. The so called N-terminal domain is actually 3 structural domains, of which this is the central EF hand domain.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Protein sprouty homolog 2	enzyme regulator activity molecular function inhibitor activity ubiquitin-protein transferase regulator activity ubiquitin-protein transferase inhibitor activity molecular function regulator activity enzyme inhibitor activity protein binding binding kinase binding enzyme binding protein kinase binding protein kinase inhibitor activity protein kinase regulator activity protein serine/threonine kinase inhibitor activity enzyme regulator activity molecular function inhibitor activity ubiquitin-protein transferase regulator activity ubiquitin-protein transferase inhibitor activity molecular function regulator activity enzyme inhibitor activity protein binding binding kinase binding enzyme binding protein kinase binding protein kinase inhibitor activity protein kinase regulator activity protein serine/threonine kinase inhibitor activity kinase inhibitor activity kinase regulator activity protein serine/threonine kinase activator activity kinase activator activity enzyme activator activity molecular function activator activity protein kinase activator activity	lung growth developmental process multicellular organismal process developmental growth tube development growth animal organ development respiratory tube development organ growth multicellular organism development anatomical structure development lung development respiratory system development system development lung growth developmental process multicellular organismal process developmental growth tube development growth animal organ development respiratory tube development organ growth multicellular organism development anatomical structure development lung development respiratory system development system development response to fibroblast growth factor cellular response to stimulus cellular response to growth factor stimulus regulation of cellular process response to stimulus signaling negative regulation of signaling negative regulation of biological process regulation of signal transduction negative regulation of cellular response to growth factor stimulus cell surface receptor protein tyrosine kinase signaling pathway negative regulation of cell communication cell communication cellular response to endogenous stimulus negative regulation of cellular process signal transduction enzyme-linked receptor protein signaling pathway negative regulation of fibroblast growth factor receptor signaling pathway regulation of biological process regulation of signaling cell surface receptor signaling pathway negative regulation of response to stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus biological regulation negative regulation of signal transduction regulation of response to stimulus fibroblast growth factor receptor signaling pathway regulation of cell communication cellular process response to growth factor cellular response to fibroblast growth factor stimulus regulation of fibroblast growth factor receptor signaling pathway regulation of protein modification process regulation of protein phosphorylation regulation of peptidyl-threonine phosphorylation negative regulation of phosphate metabolic process negative regulation of cellular metabolic process regulation of primary metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process peptidyl-amino acid modification protein metabolic process peptidyl-threonine modification protein modification process phosphorus metabolic process negative regulation of protein metabolic process negative regulation of macromolecule metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process cellular metabolic process negative regulation of metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process negative regulation of protein phosphorylation macromolecule modification negative regulation of peptidyl-threonine phosphorylation negative regulation of phosphorus metabolic process metabolic process regulation of phosphorylation regulation of phosphorus metabolic process macromolecule metabolic process negative regulation of phosphorylation regulation of metabolic process peptidyl-threonine phosphorylation positive regulation of cell communication positive regulation of signal transduction positive regulation of biological process intracellular signal transduction positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette positive regulation of cellular process positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade MAPK cascade ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling ear morphogenesis embryonic organ morphogenesis ear development sensory organ development embryonic morphogenesis embryo development anatomical structure morphogenesis sensory organ morphogenesis inner ear development inner ear morphogenesis animal organ morphogenesis embryonic organ development negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death negative regulation of post-translational protein modification regulation of protein ubiquitination protein ubiquitination negative regulation of protein ubiquitination regulation of protein modification by small protein conjugation or removal negative regulation of protein modification by small protein conjugation or removal regulation of post-translational protein modification post-translational protein modification protein modification by small protein conjugation protein modification by small protein conjugation or removal cellular biosynthetic process positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process regulation of biosynthetic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process positive regulation of cellular biosynthetic process neurotrophin signaling pathway neurotrophin TRK receptor signaling pathway regulation of neurotrophin TRK receptor signaling pathway negative regulation of neurotrophin TRK receptor signaling pathway positive regulation of phosphorylation positive regulation of protein metabolic process regulation of peptidyl-serine phosphorylation positive regulation of phosphate metabolic process peptidyl-serine modification positive regulation of protein modification process peptidyl-serine phosphorylation positive regulation of protein phosphorylation positive regulation of phosphorus metabolic process positive regulation of peptidyl-serine phosphorylation negative regulation of intracellular signal transduction negative regulation of ERK1 and ERK2 cascade negative regulation of MAPK cascade small GTPase-mediated signal transduction regulation of small GTPase mediated signal transduction regulation of Ras protein signal transduction Ras protein signal transduction negative regulation of small GTPase mediated signal transduction negative regulation of Ras protein signal transduction regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of ERBB signaling pathway regulation of epidermal growth factor receptor signaling pathway epidermal growth factor receptor signaling pathway positive regulation of epidermal growth factor receptor signaling pathway regulation of ERBB signaling pathway ERBB signaling pathway negative regulation of transforming growth factor beta receptor signaling pathway cell surface receptor protein serine/threonine kinase signaling pathway cellular response to transforming growth factor beta stimulus regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of transforming growth factor beta receptor signaling pathway regulation of cellular response to transforming growth factor beta stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway transforming growth factor beta receptor superfamily signaling pathway negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway establishment of organelle localization cellular localization microtubule cytoskeleton organization spindle localization establishment or maintenance of cell polarity mitotic cell cycle cellular component organization localization establishment of mitotic spindle localization establishment of spindle localization establishment of spindle orientation organelle localization establishment of localization in cell cell cycle cellular component organization or biogenesis microtubule cytoskeleton organization involved in mitosis cell cycle process establishment of localization establishment of cell polarity organelle organization mitotic cell cycle process establishment of mitotic spindle orientation microtubule-based process cytoskeleton organization negative regulation of lens fiber cell differentiation cellular developmental process regulation of developmental process visual system development regulation of cell differentiation regulation of lens fiber cell differentiation epithelial cell differentiation regulation of epithelial cell differentiation cell differentiation regulation of multicellular organismal process negative regulation of cell differentiation sensory system development epithelium development regulation of multicellular organismal development negative regulation of epithelial cell differentiation negative regulation of developmental process eye development tissue development camera-type eye development lens fiber cell differentiation negative regulation of multicellular organismal process lens development in camera-type eye negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation cell fate commitment positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion system process sensory perception nervous system process sensory perception of sound sensory perception of mechanical stimulus regulation of epithelial to mesenchymal transition mesenchyme development negative regulation of epithelial to mesenchymal transition epithelial to mesenchymal transition mesenchymal cell differentiation negative regulation of vascular endothelial growth factor signaling pathway regulation of vascular endothelial growth factor signaling pathway regulation of cellular response to vascular endothelial growth factor stimulus vascular endothelial growth factor signaling pathway cellular response to vascular endothelial growth factor stimulus negative regulation of cellular response to vascular endothelial growth factor stimulus angiogenesis regulation of vasculature development tube morphogenesis regulation of anatomical structure morphogenesis blood vessel development blood vessel morphogenesis negative regulation of blood vessel morphogenesis negative regulation of angiogenesis vasculature development circulatory system development negative regulation of vasculature development regulation of angiogenesis anatomical structure formation involved in morphogenesis branching morphogenesis of an epithelial tube lung morphogenesis epithelial tube morphogenesis axis elongation bud elongation involved in lung branching branch elongation of an epithelium morphogenesis of an epithelium developmental growth involved in morphogenesis tissue morphogenesis morphogenesis of a branching structure epithelial tube branching involved in lung morphogenesis morphogenesis of a branching epithelium regulation of cellular component organization negative regulation of cellular component organization cell projection organization regulation of cell projection organization negative regulation of cell projection organization response to peptide response to chemical response to cytokine response to leukemia inhibitory factor cellular response to cytokine stimulus cellular response to leukemia inhibitory factor	membrane cellular anatomical entity ruffle cell leading edge plasma membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection ruffle membrane plasma membrane region cell projection membrane polymeric cytoskeletal fiber intracellular anatomical structure membrane cellular anatomical entity ruffle cell leading edge plasma membrane leading edge membrane plasma membrane bounded cell projection cell periphery cell projection ruffle membrane plasma membrane region cell projection membrane polymeric cytoskeletal fiber intracellular anatomical structure microtubule end intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton non-membrane-bounded organelle actin cytoskeleton cytoplasm cytosol membrane-bounded organelle nucleus intracellular membrane-bounded organelle
B	E3 ubiquitin-protein ligase CBL	phosphoprotein binding phosphotyrosine residue binding protein binding binding protein phosphorylated amino acid binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity phosphoprotein binding phosphotyrosine residue binding protein binding binding protein phosphorylated amino acid binding aminoacyltransferase activity ubiquitin-like protein transferase activity catalytic activity, acting on a protein acyltransferase activity ubiquitin-like protein ligase activity ubiquitin protein ligase activity transferase activity catalytic activity ubiquitin-protein transferase activity SH3 domain binding protein domain specific binding cell adhesion molecule binding cadherin binding signaling receptor binding ephrin receptor binding protein tyrosine kinase binding kinase binding receptor tyrosine kinase binding enzyme binding protein kinase binding cation binding ion binding calcium ion binding metal ion binding small molecule binding phosphatidylinositol 3-kinase binding phosphatidylinositol 3-kinase regulatory subunit binding	cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction cellular response to stimulus cellular response to stress response to stimulus DNA damage response response to stress cellular process developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development system development regulation of biological process regulation of cellular process cell surface receptor signaling pathway signaling biological regulation response to cytokine cytokine-mediated signaling pathway cell communication response to peptide response to chemical cellular response to cytokine stimulus signal transduction response to ketone response to lipid response to oxygen-containing compound response to testosterone response to organic cyclic compound response to decreased oxygen levels cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels cellular response to chemical stimulus response to hypoxia response to oxygen levels response to abiotic stimulus biological process involved in interspecies interaction between organisms symbiont entry into host cell viral process symbiont entry into host viral life cycle biological process involved in interaction with host biological process involved in symbiotic interaction protein autoubiquitination primary metabolic process protein ubiquitination macromolecule modification metabolic process protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal negative regulation of signaling negative regulation of ERBB signaling pathway negative regulation of biological process regulation of signal transduction cell surface receptor protein tyrosine kinase signaling pathway negative regulation of cell communication regulation of epidermal growth factor receptor signaling pathway negative regulation of cellular process epidermal growth factor receptor signaling pathway enzyme-linked receptor protein signaling pathway regulation of signaling regulation of ERBB signaling pathway negative regulation of response to stimulus negative regulation of signal transduction regulation of response to stimulus negative regulation of epidermal growth factor receptor signaling pathway ERBB signaling pathway regulation of cell communication positive regulation of cell communication positive regulation of signal transduction positive regulation of biological process positive regulation of response to stimulus positive regulation of ERBB signaling pathway positive regulation of cellular process positive regulation of epidermal growth factor receptor signaling pathway positive regulation of signaling cellular response to endogenous stimulus cellular response to growth factor stimulus response to endogenous stimulus cellular response to nerve growth factor stimulus response to nerve growth factor response to growth factor catabolic process proteolysis involved in protein catabolic process protein catabolic process macromolecule catabolic process modification-dependent macromolecule catabolic process modification-dependent protein catabolic process proteolysis ubiquitin-dependent protein catabolic process protein polyubiquitination regulation of localization import into cell positive regulation of cellular component organization regulation of cellular component organization transport vesicle-mediated transport cellular component organization localization positive regulation of endocytosis cellular component organization or biogenesis positive regulation of receptor-mediated endocytosis regulation of endocytosis regulation of transport regulation of receptor-mediated endocytosis regulation of vesicle-mediated transport establishment of localization positive regulation of transport endocytosis receptor-mediated endocytosis platelet-derived growth factor receptor-alpha signaling pathway platelet-derived growth factor receptor signaling pathway regulation of platelet-derived growth factor receptor signaling pathway regulation of platelet-derived growth factor receptor-alpha signaling pathway protein monoubiquitination response to nutrient levels response to starvation cellular response to platelet-derived growth factor stimulus response to platelet-derived growth factor negative regulation of programmed cell death regulation of apoptotic process regulation of programmed cell death cell death negative regulation of apoptotic process apoptotic process programmed cell death response to activity small GTPase-mediated signal transduction regulation of small GTPase mediated signal transduction regulation of Rap protein signal transduction intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette Rap protein signal transduction regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of intracellular signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction protein localization ubiquitin-dependent endocytosis establishment of protein localization cellular localization nitrogen compound transport establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle response to alcohol response to ethanol establishment of organelle localization regulated exocytosis cell activation involved in immune response leukocyte degranulation myeloid leukocyte activation myeloid leukocyte mediated immunity leukocyte activation secretion by cell organelle localization leukocyte activation involved in immune response establishment of localization in cell mast cell activation leukocyte mediated immunity mast cell mediated immunity immune response secretion cell activation vacuolar localization export from cell mast cell degranulation myeloid cell activation involved in immune response immune effector process mast cell activation involved in immune response exocytosis immune system process lysosome localization response to ionizing radiation response to radiation response to gamma radiation	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane raft protein-containing complex plasma membrane protein complex plasma membrane raft membrane plasma membrane membrane protein complex caveola membrane microdomain cell periphery intracellular anatomical structure cytoplasm cellular anatomical entity cytosol membrane raft protein-containing complex plasma membrane protein complex plasma membrane raft membrane plasma membrane membrane protein complex caveola membrane microdomain cell periphery flotillin complex plasma membrane region membrane-bounded organelle intracellular organelle Golgi apparatus organelle intracellular membrane-bounded organelle endomembrane system perinuclear region of cytoplasm cell projection cilium plasma membrane bounded cell projection anchoring junction cell junction focal adhesion cell-substrate junction growth cone axon distal axon neuron projection site of polarized growth

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR007875	Sprouty	Family
A	IPR051192	Sprouty domain-containing protein	Family
B	IPR024162	Adaptor protein Cbl	Family
B	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
B	IPR009060	UBA-like superfamily	Homologous Superfamily
B	IPR001841	Zinc finger, RING-type	Domain
B	IPR036860	SH2 domain superfamily	Homologous Superfamily
B	IPR024159	Adaptor protein Cbl, PTB domain	Domain
B	IPR003153	Adaptor protein Cbl, N-terminal helical	Domain
B	IPR011992	EF-hand domain pair	Homologous Superfamily
B	IPR015940	Ubiquitin-associated domain	Domain
B	IPR018957	Zinc finger, C3HC4 RING-type	Domain
B	IPR017907	Zinc finger, RING-type, conserved site	Conserved Site
B	IPR014741	Adaptor protein Cbl, EF hand-like	Domain
B	IPR014742	Adaptor protein Cbl, SH2-like domain	Domain
B	IPR036537	Adaptor protein Cbl, N-terminal domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O43597	cleft palate IgA glomerulonephritis Craniofacial Abnormalities IgA nephropathy, susceptibility to, 3 lung cancer medulloblastoma psoriasis adrenal cortex carcinoma breast carcinoma ductal breast carcinoma in situ hydrolethalus syndrome interstitial cystitis lung adenocarcinoma lung carcinoma ovarian cancer cleft palate IgA glomerulonephritis Craniofacial Abnormalities IgA nephropathy, susceptibility to, 3 lung cancer medulloblastoma psoriasis adrenal cortex carcinoma breast carcinoma ductal breast carcinoma in situ hydrolethalus syndrome interstitial cystitis lung adenocarcinoma lung carcinoma ovarian cancer subependymal giant cell astrocytoma astrocytic tumor cleft lip endogenous depression invasive ductal breast carcinoma lung benign neoplasm lung disease pituitary cancer breast cancer glioblastoma large cell medulloblastoma
B	Pharos: P22681	juvenile myelomonocytic leukemia CBL-related disorder vasculitis male infertility cryptorchidism intellectual disability myelodysplastic syndrome ovarian cancer Abdominal Cryptorchidism primitive neuroectodermal tumor developmental disability glioblastoma hydrops fetalis pancreatic intraductal papillary-mucinous neoplasm acute myeloid leukemia juvenile myelomonocytic leukemia CBL-related disorder vasculitis male infertility cryptorchidism intellectual disability myelodysplastic syndrome ovarian cancer Abdominal Cryptorchidism primitive neuroectodermal tumor developmental disability glioblastoma hydrops fetalis pancreatic intraductal papillary-mucinous neoplasm acute myeloid leukemia rheumatoid arthritis cancer ulcerative colitis large cell medulloblastoma malignant glioma osteosarcoma Pick disease atypical teratoid rhabdoid tumor Sjogren syndrome congenital anemia genetic endocrine growth disease hematopoietic and lymphoid system neoplasm

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A	PTR	Parent Component: TYR RESID: AA0039 PSI-MOD : O4'-phospho-L-tyrosine MOD:00048

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.