3ENH
Crystal structure of Cgi121/Bud32/Kae1 complex
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Chains | Type | Family Name | Domain Identifier | Family Identifier | Provenance Source (Version) |
---|---|---|---|---|---|
A | SCOP2B Superfamily | Protein kinase-like (PK-like) | 8058158 | 3000066 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Actin-like ATPases | 8092403 | 3000092 | SCOP2B (2022-06-29) |
A | SCOP2B Superfamily | Actin-like ATPases | 8058156 | 3000092 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Protein kinase-like (PK-like) | 8058158 | 3000066 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Actin-like ATPases | 8058156 | 3000092 | SCOP2B (2022-06-29) |
B | SCOP2B Superfamily | Actin-like ATPases | 8092403 | 3000092 | SCOP2B (2022-06-29) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | RIO1 | e3enhA5 | A: a+b complex topology | X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology) | H: Protein kinase/SAICAR synthase/ATP-grasp | T: Protein kinase | F: RIO1 | ECOD (1.6) |
A | Peptidase_M22_C_1 | e3enhA3 | A: mixed a+b and a/b | X: Ribonuclease H-like | H: Ribonuclease H-like (From Topology) | T: Ribonuclease H-like | F: Peptidase_M22_C_1 | ECOD (1.6) |
A | Peptidase_M22_N | e3enhA4 | A: mixed a+b and a/b | X: Ribonuclease H-like | H: Ribonuclease H-like (From Topology) | T: Ribonuclease H-like | F: Peptidase_M22_N | ECOD (1.6) |
B | RIO1 | e3enhB5 | A: a+b complex topology | X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology) | H: Protein kinase/SAICAR synthase/ATP-grasp | T: Protein kinase | F: RIO1 | ECOD (1.6) |
B | Peptidase_M22_C_1 | e3enhB3 | A: mixed a+b and a/b | X: Ribonuclease H-like | H: Ribonuclease H-like (From Topology) | T: Ribonuclease H-like | F: Peptidase_M22_C_1 | ECOD (1.6) |
B | Peptidase_M22_N | e3enhB4 | A: mixed a+b and a/b | X: Ribonuclease H-like | H: Ribonuclease H-like (From Topology) | T: Ribonuclease H-like | F: Peptidase_M22_N | ECOD (1.6) |
C | CGI-121 | e3enhC1 | A: a+b two layers | X: Alpha-beta plaits | H: PF0523-like (From Topology) | T: PF0523-like | F: CGI-121 | ECOD (1.6) |
D | CGI-121 | e3enhD1 | A: a+b two layers | X: Alpha-beta plaits | H: PF0523-like (From Topology) | T: PF0523-like | F: CGI-121 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.30.420.40 | Alpha Beta | 2-Layer Sandwich | Nucleotidyltransferase | domain 5 | CATH (4.3.0) |
A | 3.30.200.20 | Alpha Beta | 2-Layer Sandwich | Phosphorylase Kinase | domain 1 | CATH (4.3.0) |
A | 1.10.510.10 | Mainly Alpha | Orthogonal Bundle | Transferase(Phosphotransferase) | domain 1 | CATH (4.3.0) |
B | 3.30.420.40 | Alpha Beta | 2-Layer Sandwich | Nucleotidyltransferase | domain 5 | CATH (4.3.0) |
B | 3.30.200.20 | Alpha Beta | 2-Layer Sandwich | Phosphorylase Kinase | domain 1 | CATH (4.3.0) |
B | 1.10.510.10 | Mainly Alpha | Orthogonal Bundle | Transferase(Phosphotransferase) | domain 1 | CATH (4.3.0) |
C | 3.30.2380.10 | Alpha Beta | 2-Layer Sandwich | PF0523-like | CGI121/TPRKB | CATH (4.3.0) |
D | 3.30.2380.10 | Alpha Beta | 2-Layer Sandwich | PF0523-like | CGI121/TPRKB | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00814 | tRNA N6-adenosine threonylcarbamoyltransferase (TsaD) | tRNA N6-adenosine threonylcarbamoyltransferase | - | Family | |
PF01163 | RIO1 family (RIO1) | RIO1 family | - | Family | |
PF08617 | Kinase binding protein CGI-121 (CGI-121) | Kinase binding protein CGI-121 | CGI-121 has been shown to bind to the p53-related protein kinase (PRPK) [1]. PRPK is a novel protein kinase which binds to and induces phosphorylation of the tumour suppressor protein p53. CGI-121 is part of a conserved protein complex, KEOPS. The K ... | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR022495 | Serine/threonine-protein kinase Bud32 | Family | |
IPR017860 | Peptidase M22, conserved site | Conserved Site | |
IPR043129 | ATPase, nucleotide binding domain | Homologous Superfamily | |
IPR008266 | Tyrosine-protein kinase, active site | Active Site | |
IPR009220 | Probable bifunctional tRNA threonylcarbamoyladenosine biosynthesis protein | Family | |
IPR011009 | Protein kinase-like domain superfamily | Homologous Superfamily | |
IPR000905 | Gcp-like domain | Domain | |
IPR034680 | tRNA N6-adenosine threonylcarbamoyltransferase Kae1, archaeal/eukaryotic | Family | |
IPR017861 | Kae1/TsaD family | Family | |
IPR000719 | Protein kinase domain | Domain | |
IPR036504 | CGI121/TPRKB superfamily | Homologous Superfamily | |
IPR013926 | CGI121/TPRKB | Family |