3EXJ

Crystal Structure of a p53 Core Tetramer Bound to DNA

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3exja_	All beta proteins	Common fold of diphtheria toxin/transcription factors/cytochrome f	p53-like transcription factors	p53 DNA-binding domain-like	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)
B	d3exjb_	All beta proteins	Common fold of diphtheria toxin/transcription factors/cytochrome f	p53-like transcription factors	p53 DNA-binding domain-like	automated matches	mouse (Mus musculus ) [TaxId: 10090 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	p53-like transcription factors	8033311	3000758	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	p53-like transcription factors	8033311	3000758	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	P53	e3exjA1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: P53	ECOD (1.6)
B	P53	e3exjB1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Common fold of diphtheria toxin/transcription factors/cytochrome f	F: P53	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.60.40.720	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)
B	2.60.40.720	Mainly Beta	Sandwich	Immunoglobulin-like		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00870	P53 DNA-binding domain (P53)	P53 DNA-binding domain	This family contains one anomalous member, viz: Zea mays (Q6JAD8). This sequence is identical to human P53 and would appear to be a a human contaminant within the Zea mays sampling effort.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	mouse p53 core domain	TFIID-class transcription factor complex binding transcription factor binding basal transcription machinery binding protein-containing complex binding protein binding binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding sequence-specific DNA binding DNA binding organic cyclic compound binding nucleic acid binding protein-folding chaperone binding TFIID-class transcription factor complex binding transcription factor binding basal transcription machinery binding protein-containing complex binding protein binding binding basal RNA polymerase II transcription machinery binding general transcription initiation factor binding RNA polymerase II general transcription initiation factor binding sequence-specific DNA binding DNA binding organic cyclic compound binding nucleic acid binding protein-folding chaperone binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding enzyme binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription regulator activity DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription activator activity molecular function activator activity molecular function regulator activity mRNA 3'-UTR binding RNA binding mRNA binding sequence-specific double-stranded DNA binding transcription cis-regulatory region binding double-stranded DNA binding core promoter sequence-specific DNA binding transcription regulatory region nucleic acid binding identical protein binding molecular condensate scaffold activity protein-macromolecule adaptor activity molecular adaptor activity ATP-dependent DNA/DNA annealing activity DNA/DNA annealing activity annealing activity single-stranded DNA binding ATP-dependent activity histone deacetylase binding enzyme regulator activity histone deacetylase regulator activity chromatin binding promoter-specific chromatin binding protein phosphatase binding phosphatase binding protein phosphatase 2A binding protease binding MDM2/MDM4 family protein binding cation binding transition metal ion binding copper ion binding ion binding metal ion binding small molecule binding transcription coregulator binding protein tyrosine kinase binding kinase binding signaling receptor binding receptor tyrosine kinase binding protein kinase binding p53 binding DNA-binding transcription repressor activity, RNA polymerase II-specific DNA-binding transcription repressor activity RNA polymerase II-specific DNA-binding transcription factor binding DNA-binding transcription factor binding RNA polymerase II transcription regulatory region sequence-specific DNA binding cis-regulatory region sequence-specific DNA binding RNA polymerase II cis-regulatory region sequence-specific DNA binding protein heterodimerization activity protein dimerization activity transmembrane transporter binding disordered domain specific binding protein domain specific binding	regulation of protein stability biological regulation regulation of biological quality protein stabilization membrane organization transport apoptotic mitochondrial changes cell death establishment of localization cellular component organization mitochondrial membrane organization localization organelle organization cellular process regulation of protein stability biological regulation regulation of biological quality protein stabilization membrane organization transport apoptotic mitochondrial changes cell death establishment of localization cellular component organization mitochondrial membrane organization localization organelle organization cellular process regulation of membrane permeability regulation of mitochondrial membrane permeability involved in apoptotic process apoptotic process cellular component organization or biogenesis regulation of mitochondrial membrane permeability programmed cell death mitochondrion organization mitochondrial transport cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling signal transduction by p53 class mediator intracellular signal transduction cell communication apoptotic signaling pathway intrinsic apoptotic signaling pathway by p53 class mediator signal transduction intrinsic apoptotic signaling pathway multicellular organismal process cellular developmental process regulation of developmental process negative regulation of biological process cell development regulation of neurogenesis regulation of cell differentiation regulation of gliogenesis negative regulation of glial cell proliferation regulation of cell development regulation of nervous system development neurogenesis multicellular organism development negative regulation of neurogenesis regulation of glial cell proliferation gliogenesis cell differentiation anatomical structure development negative regulation of cellular process regulation of multicellular organismal process negative regulation of nervous system development negative regulation of cell differentiation system development developmental process regulation of multicellular organismal development negative regulation of cell population proliferation cell population proliferation negative regulation of developmental process nervous system development negative regulation of gliogenesis negative regulation of cell development regulation of cell population proliferation glial cell proliferation negative regulation of multicellular organismal process response to X-ray response to ionizing radiation response to radiation response to abiotic stimulus replicative senescence metabolic process transcription preinitiation complex assembly positive regulation of macromolecule biosynthetic process regulation of primary metabolic process cellular component biogenesis nucleobase-containing compound metabolic process DNA-templated transcription positive regulation of metabolic process regulation of DNA-templated transcription initiation regulation of RNA metabolic process cellular component assembly transcription by RNA polymerase II positive regulation of macromolecule metabolic process regulation of nucleobase-containing compound metabolic process transcription initiation at RNA polymerase II promoter regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process primary metabolic process positive regulation of transcription by RNA polymerase II positive regulation of DNA-templated transcription initiation positive regulation of RNA metabolic process regulation of gene expression biosynthetic process RNA polymerase II preinitiation complex assembly regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of DNA-templated transcription regulation of metabolic process regulation of RNA polymerase II transcription preinitiation complex assembly regulation of cellular component organization positive regulation of cellular component organization positive regulation of DNA-templated transcription positive regulation of biological process RNA metabolic process protein-DNA complex organization RNA biosynthetic process nucleic acid biosynthetic process regulation of protein-containing complex assembly positive regulation of protein-containing complex assembly positive regulation of biosynthetic process protein-containing complex assembly positive regulation of cellular process regulation of RNA biosynthetic process regulation of biosynthetic process positive regulation of RNA polymerase II transcription preinitiation complex assembly protein-containing complex organization positive regulation of cellular component biogenesis positive regulation of transcription initiation by RNA polymerase II protein-DNA complex assembly regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression regulation of cellular component biogenesis macromolecule biosynthetic process DNA-templated transcription initiation nucleic acid metabolic process positive regulation of RNA biosynthetic process regulation of transcription initiation by RNA polymerase II head development animal organ development brain development cerebellum development central nervous system development metencephalon development hindbrain development positive regulation of miRNA transcription positive regulation of miRNA metabolic process miRNA transcription regulation of miRNA metabolic process miRNA metabolic process regulation of miRNA transcription DNA metabolic process cellular response to stress nucleotide-excision repair DNA damage response response to stress DNA repair response to biotic stimulus cellular response to biotic stimulus ER overload response ER-nucleus signaling pathway response to endoplasmic reticulum stress multicellular organism growth developmental growth growth regulation of amide metabolic process negative regulation of small molecule metabolic process carbohydrate catabolic process carbohydrate derivative metabolic process regulation of generation of precursor metabolites and energy negative regulation of nucleotide metabolic process regulation of small molecule metabolic process regulation of phosphate metabolic process regulation of nucleotide metabolic process regulation of pentose-phosphate shunt pentose-phosphate shunt phosphate-containing compound metabolic process pyridine-containing compound metabolic process small molecule metabolic process negative regulation of nucleobase-containing compound metabolic process phosphorus metabolic process pyridine nucleotide metabolic process nucleoside phosphate metabolic process nicotinamide nucleotide metabolic process regulation of carbohydrate catabolic process negative regulation of metabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process negative regulation of pentose-phosphate shunt regulation of phosphorus metabolic process catabolic process negative regulation of purine nucleotide metabolic process negative regulation of phosphate metabolic process glucose 6-phosphate metabolic process purine nucleotide metabolic process nucleobase-containing small molecule metabolic process regulation of NADP metabolic process amide metabolic process regulation of carbohydrate metabolic process carbohydrate metabolic process generation of precursor metabolites and energy regulation of catabolic process purine-containing compound metabolic process NADP metabolic process NADPH regeneration organophosphate metabolic process negative regulation of phosphorus metabolic process negative regulation of RNA biosynthetic process negative regulation of macromolecule metabolic process negative regulation of DNA-templated transcription negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of RNA metabolic process cell cycle regulation of cell cycle positive regulation of cell cycle regulation of leukocyte apoptotic process regulation of lymphocyte apoptotic process leukocyte apoptotic process regulation of apoptotic process regulation of programmed cell death lymphocyte apoptotic process thymocyte apoptotic process regulation of thymocyte apoptotic process regulation of T cell apoptotic process T cell apoptotic process somitogenesis epithelium development chordate embryonic development segmentation anterior/posterior pattern specification pattern specification process embryo development tissue development regionalization anatomical structure morphogenesis embryo development ending in birth or egg hatching somite development anatomical structure formation involved in morphogenesis negative regulation of programmed cell death negative regulation of apoptotic process fibroblast apoptotic process regulation of fibroblast apoptotic process negative regulation of proteolysis regulation of protein metabolic process regulation of proteolysis proteolysis protein metabolic process negative regulation of protein metabolic process positive regulation of cardiac muscle cell apoptotic process positive regulation of programmed cell death muscle cell apoptotic process positive regulation of striated muscle cell apoptotic process regulation of cardiac muscle cell apoptotic process regulation of muscle cell apoptotic process positive regulation of apoptotic process cardiac muscle cell apoptotic process positive regulation of muscle cell apoptotic process regulation of striated muscle cell apoptotic process striated muscle cell apoptotic process small GTPase-mediated signal transduction Ras protein signal transduction intracellular signaling cassette immune system development hematopoietic or lymphoid organ development bone marrow development skeletal system development immune system process bone development positive regulation of locomotion regulation of cell motility regulation of leukocyte migration positive regulation of leukocyte migration positive regulation of cell migration leukocyte migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration regulation of immune system process cell motility positive regulation of immune system process locomotion response to gamma radiation response to oxidative stress immune response cell activation lymphocyte activation cell activation involved in immune response leukocyte proliferation leukocyte activation immune effector process T cell proliferation involved in immune response T cell activation involved in immune response mononuclear cell proliferation T cell activation lymphocyte proliferation leukocyte activation involved in immune response lymphocyte activation involved in immune response T cell proliferation oligodendrocyte apoptotic process glial cell apoptotic process regulation of protein modification process positive regulation of phosphorylation regulation of protein phosphorylation positive regulation of protein metabolic process peptidyl-tyrosine modification positive regulation of phosphate metabolic process positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process peptidyl-amino acid modification protein modification process positive regulation of protein phosphorylation protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of peptidyl-tyrosine phosphorylation macromolecule modification regulation of phosphorylation peptidyl-tyrosine phosphorylation cell cycle G2/M phase transition regulation of cell cycle phase transition regulation of cell cycle process regulation of cell cycle G2/M phase transition cell cycle phase transition cell cycle process regulation of cellular senescence cellular senescence hemopoiesis B cell activation B cell lineage commitment mononuclear cell differentiation lymphocyte differentiation B cell differentiation cell fate commitment leukocyte differentiation protein complex oligomerization protein tetramerization positive regulation of gene expression neuroblast proliferation negative regulation of neural precursor cell proliferation regulation of neuroblast proliferation negative regulation of neuroblast proliferation regulation of neural precursor cell proliferation generation of neurons neural precursor cell proliferation regulation of execution phase of apoptosis positive regulation of execution phase of apoptosis execution phase of apoptosis in utero embryonic development T cell differentiation in thymus T cell differentiation mRNA transcription mRNA metabolic process rhythmic process behavior circadian behavior rhythmic behavior circadian rhythm positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction regulation of intrinsic apoptotic signaling pathway positive regulation of apoptotic signaling pathway positive regulation of response to stimulus regulation of intracellular signal transduction regulation of signaling positive regulation of intracellular signal transduction regulation of response to stimulus regulation of cell communication positive regulation of intrinsic apoptotic signaling pathway regulation of apoptotic signaling pathway positive regulation of signaling cell surface receptor signaling pathway response to cytokine cytokine-mediated signaling pathway response to peptide cellular response to tumor necrosis factor response to chemical tumor necrosis factor-mediated signaling pathway cellular response to cytokine stimulus response to tumor necrosis factor programmed necrotic cell death regulation of programmed necrotic cell death positive regulation of programmed necrotic cell death cellular response to oxidative stress cellular response to chemical stress oxidative stress-induced premature senescence cellular response to chemical stimulus stress-induced premature senescence cellular response to ionizing radiation cellular response to radiation cellular response to environmental stimulus cellular response to gamma radiation cellular response to abiotic stimulus regulation of DNA biosynthetic process negative regulation of DNA metabolic process DNA biosynthetic process negative regulation of DNA biosynthetic process regulation of DNA metabolic process chromosome organization neuron apoptotic process regulation of neuron apoptotic process regulation of cellular response to stress DNA damage response, signal transduction by p53 class mediator regulation of response to stress regulation of signal transduction by p53 class mediator regulation of DNA damage response, signal transduction by p53 class mediator signal transduction in response to DNA damage negative regulation of telomere maintenance telomere organization negative regulation of telomere maintenance via telomerase RNA-templated DNA biosynthetic process telomere maintenance via telomere lengthening negative regulation of chromosome organization negative regulation of cellular component organization regulation of chromosome organization regulation of telomere maintenance via telomere lengthening regulation of organelle organization telomere maintenance regulation of telomere maintenance negative regulation of telomere maintenance via telomere lengthening telomere maintenance via telomerase regulation of telomere maintenance via telomerase negative regulation of organelle organization response to light stimulus response to UV cellular response to light stimulus cellular response to UV intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress monosaccharide metabolic process glucose catabolic process to lactate via pyruvate energy derivation by oxidation of organic compounds oxoacid metabolic process organic hydroxy compound metabolic process organic acid metabolic process fermentation lactate metabolic process glycolytic fermentation hexose catabolic process carboxylic acid metabolic process hexose metabolic process glucose catabolic process monocarboxylic acid metabolic process glucose catabolic process to lactate monosaccharide catabolic process small molecule catabolic process glucose metabolic process double-strand break repair release of cytochrome c from mitochondria response to xenobiotic stimulus macroautophagy autophagy regulation of autophagy mitophagy regulation of autophagy of mitochondrion process utilizing autophagic mechanism negative regulation of catabolic process negative regulation of autophagy of mitochondrion regulation of mitophagy negative regulation of mitophagy negative regulation of macroautophagy regulation of macroautophagy negative regulation of autophagy autophagy of mitochondrion heart development circulatory system development positive regulation of gene expression, epigenetic chromatin organization chromatin remodeling epigenetic regulation of gene expression transcription initiation-coupled chromatin remodeling response to ischemia tissue remodeling regulation of tissue remodeling regulation of stem cell proliferation negative regulation of stem cell proliferation stem cell proliferation biological process involved in interspecies interaction between organisms response to type II interferon cellular response to type II interferon interferon-mediated signaling pathway innate immune response response to external biotic stimulus response to other organism defense response type II interferon-mediated signaling pathway defense response to symbiont response to external stimulus defense response to other organism T cell lineage commitment reactive oxygen species metabolic process negative regulation of reactive oxygen species metabolic process regulation of reactive oxygen species metabolic process fibroblast proliferation cellular response to xenobiotic stimulus negative regulation of transcription by RNA polymerase II negative regulation of DNA replication DNA replication regulation of DNA replication response to osmotic stress response to salt stress cellular response to growth factor stimulus cell surface receptor protein serine/threonine kinase signaling pathway cellular response to transforming growth factor beta stimulus response to endogenous stimulus cellular response to endogenous stimulus response to transforming growth factor beta transforming growth factor beta receptor signaling pathway response to growth factor transforming growth factor beta receptor superfamily signaling pathway enzyme-linked receptor protein signaling pathway DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator DNA damage response, signal transduction resulting in transcription regulation of intrinsic apoptotic signaling pathway by p53 class mediator cellular response to oxygen levels cellular response to hypoxia cellular response to decreased oxygen levels response to decreased oxygen levels intrinsic apoptotic signaling pathway in response to hypoxia response to hypoxia response to oxygen levels positive regulation of thymocyte apoptotic process positive regulation of leukocyte apoptotic process positive regulation of lymphocyte apoptotic process positive regulation of T cell apoptotic process positive regulation of reactive oxygen species metabolic process cellular response to UV-C response to UV-C positive regulation of cellular senescence necroptotic process negative regulation of gene expression positive regulation of mitochondrial membrane permeability positive regulation of membrane permeability spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation positive regulation of organelle organization regulation of release of cytochrome c from mitochondria positive regulation of release of cytochrome c from mitochondria regulation of mitochondrion organization viral process cellular response to nutrient levels response to nutrient levels response to starvation cellular response to glucose starvation cellular response to starvation positive regulation of neuron apoptotic process regulation of growth negative regulation of cell growth regulation of cell growth cell growth negative regulation of growth protein localization establishment of protein localization cellular localization nitrogen compound transport nucleocytoplasmic transport nuclear transport intracellular transport protein localization to nucleus import into nucleus establishment of protein localization to organelle protein transport cellular macromolecule localization macromolecule localization protein localization to organelle establishment of localization in cell protein import into nucleus intracellular protein transport DNA damage checkpoint signaling negative regulation of cell cycle regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle negative regulation of mitotic cell cycle regulation of mitotic cell cycle mitotic DNA integrity checkpoint signaling mitotic DNA damage checkpoint signaling negative regulation of cell cycle phase transition negative regulation of G1/S transition of mitotic cell cycle mitotic G1/S transition checkpoint signaling negative regulation of mitotic cell cycle phase transition negative regulation of cell cycle G1/S phase transition DNA integrity checkpoint signaling negative regulation of cell cycle process cell cycle checkpoint signaling regulation of mitotic cell cycle phase transition mitotic cell cycle checkpoint signaling mitotic G1 DNA damage checkpoint signaling mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle G1/S transition of mitotic cell cycle mitotic cell cycle phase transition cardiac chamber morphogenesis heart morphogenesis cardiac septum development cardiac septum morphogenesis cardiac chamber development animal organ morphogenesis embryonic organ development negative regulation of transforming growth factor beta receptor signaling pathway negative regulation of signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway negative regulation of cell communication regulation of transforming growth factor beta receptor signaling pathway negative regulation of response to stimulus regulation of cellular response to transforming growth factor beta stimulus regulation of cellular response to growth factor stimulus negative regulation of signal transduction negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway entrainment of circadian clock regulation of circadian rhythm photoperiodism entrainment of circadian clock by photoperiod rRNA transcription rRNA metabolic process regulation of fibroblast proliferation negative regulation of fibroblast proliferation homeostatic process regulation of intracellular pH cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis regulation of pH monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis regulation of cellular pH intracellular monoatomic ion homeostasis post-transcriptional regulation of gene expression RNA processing regulation of miRNA processing miRNA-mediated post-transcriptional gene silencing negative regulation of miRNA-mediated gene silencing post-transcriptional gene silencing miRNA processing negative regulation of post-transcriptional gene silencing regulation of miRNA-mediated gene silencing negative regulation of post-transcriptional gene silencing by regulatory ncRNA regulation of regulatory ncRNA processing regulation of gene silencing by regulatory ncRNA regulation of post-transcriptional gene silencing by regulatory ncRNA negative regulation of miRNA processing negative regulation of gene silencing by regulatory ncRNA regulatory ncRNA-mediated post-transcriptional gene silencing regulatory ncRNA processing regulatory ncRNA-mediated gene silencing regulation of post-transcriptional gene silencing negative regulation of G1 to G0 transition regulation of G1 to G0 transition G1 to G0 transition cellular response to nitrogen compound response to oxygen-containing compound response to nitrogen compound response to actinomycin D response to antibiotic cellular response to oxygen-containing compound cellular response to actinomycin D cellular response to antibiotic embryonic morphogenesis gastrulation regulation of smooth muscle cell proliferation smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation muscle cell proliferation negative regulation of carbohydrate metabolic process negative regulation of fermentation regulation of glucose catabolic process to lactate via pyruvate regulation of glucose metabolic process negative regulation of glucose catabolic process to lactate via pyruvate regulation of fermentation determination of adult lifespan stem cell differentiation hematopoietic stem cell differentiation hematopoietic progenitor cell differentiation response to reactive oxygen species cellular response to reactive oxygen species DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest mitochondrial genome maintenance mitochondrial DNA metabolic process mitochondrial DNA repair intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator intrinsic apoptotic signaling pathway in response to DNA damage	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle nucleus germ cell nucleus intracellular membrane-bounded organelle mitochondrion membrane-enclosed lumen mitochondrial matrix intracellular organelle lumen organelle lumen cytoplasm membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure organelle nucleus germ cell nucleus intracellular membrane-bounded organelle mitochondrion membrane-enclosed lumen mitochondrial matrix intracellular organelle lumen organelle lumen cytoplasm membraneless organelle intracellular membraneless organelle chromatin chromosome nuclear periphery nuclear lumen nuclear matrix centrosome microtubule organizing center cytoskeleton microtubule cytoskeleton nucleoplasm endoplasmic reticulum endomembrane system nuclear body PML body cytosol nucleolus replication fork site of double-strand break site of DNA damage protein-containing complex transcription regulator complex RNA polymerase II transcription regulator complex nuclear protein-containing complex transcription repressor complex
C	5'-D(PDGPDAPDGPDCPDAPDTPDGPDCPDTPDCP*DA)-3'	-	-	-
D	5'-D(DTPDTPDGPDAPDGPDCPDAPDTPDGPDCPDTPDC)-3'	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR012346	p53/RUNT-type transcription factor, DNA-binding domain superfamily	Homologous Superfamily
A, B	IPR036674	p53-like tetramerisation domain superfamily	Homologous Superfamily
A, B	IPR011615	p53, DNA-binding domain	Domain
A, B	IPR010991	p53, tetramerisation domain	Domain
A, B	IPR002117	p53 tumour suppressor family	Family
A, B	IPR013872	p53 transactivation domain	Domain
A, B	IPR008967	p53-like transcription factor, DNA-binding domain superfamily	Homologous Superfamily

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.