3F9C

Crystal structure of human plasma platelet activating factor acetylhydrolase covalently inhibited by diisopropylfluorophosphate

External Resource: Annotation

Domain Annotation: ECOD Classification
Domain Annotation: CATH
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Hydrolase_4	e3f9cA1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)
B	Hydrolase_4	e3f9cB1	A: a/b three-layered sandwiches	X: alpha/beta-Hydrolases (From Topology)	H: alpha/beta-Hydrolases (From Topology)	T: alpha/beta-Hydrolases	F: Hydrolase_4	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)
B	3.40.50.1820	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Alpha/Beta hydrolase fold, catalytic domain	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Platelet-activating factor acetylhydrolase	phospholipase A2 activity hydrolase activity, acting on ester bonds calcium-independent phospholipase A2 activity carboxylic ester hydrolase activity hydrolase activity catalytic activity phospholipase activity lipase activity 1-alkyl-2-acetylglycerophosphocholine esterase activity binding phospholipid binding lipid binding	plasma lipoprotein particle organization multicellular organismal process regulation of biological process low-density lipoprotein particle remodeling protein-containing complex organization protein-containing complex remodeling protein-lipid complex organization biological regulation plasma lipoprotein particle remodeling regulation of plasma lipoprotein particle levels cellular component organization protein-lipid complex remodeling cellular process cellular component organization or biogenesis plasma lipoprotein particle organization multicellular organismal process regulation of biological process low-density lipoprotein particle remodeling protein-containing complex organization protein-containing complex remodeling protein-lipid complex organization biological regulation plasma lipoprotein particle remodeling regulation of plasma lipoprotein particle levels cellular component organization protein-lipid complex remodeling cellular process cellular component organization or biogenesis glycerol ether metabolic process ether metabolic process catabolic process phospholipid catabolic process glycerophospholipid metabolic process glycerolipid catabolic process organophosphate catabolic process ether catabolic process cellular lipid catabolic process cellular catabolic process phospholipid metabolic process phosphate-containing compound metabolic process small molecule metabolic process platelet activating factor catabolic process phosphorus metabolic process lipid catabolic process platelet activating factor metabolic process cellular metabolic process primary metabolic process glycerol ether catabolic process organophosphate metabolic process cellular lipid metabolic process ether lipid metabolic process glycerophospholipid catabolic process metabolic process glycerolipid metabolic process lipid metabolic process regulation of defense response response to stimulus regulation of response to external stimulus defense response positive regulation of biological process response to external stimulus regulation of inflammatory response positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stimulus regulation of response to stress response to stress positive regulation of defense response inflammatory response phosphatidylcholine catabolic process phosphatidylcholine metabolic process cellular response to stimulus positive regulation of monocyte chemotaxis positive regulation of locomotion regulation of cell motility regulation of cellular process positive regulation of chemotaxis positive regulation of cell migration regulation of monocyte chemotaxis taxis positive regulation of cell motility regulation of cell migration myeloid leukocyte migration positive regulation of mononuclear cell migration cell migration regulation of immune system process cell motility regulation of mononuclear cell migration positive regulation of immune system process locomotion positive regulation of cellular process cell chemotaxis chemotaxis regulation of leukocyte chemotaxis regulation of leukocyte migration positive regulation of leukocyte migration positive regulation of leukocyte chemotaxis regulation of chemotaxis monocyte chemotaxis leukocyte migration cellular response to chemical stimulus immune system process response to chemical regulation of locomotion mononuclear cell migration leukocyte chemotaxis plasma lipoprotein particle oxidation peptide hormone processing cellular biosynthetic process regulation of hormone levels signaling receptor ligand precursor processing gene expression macromolecule biosynthetic process hormone metabolic process protein maturation biosynthetic process proteolysis protein processing amide metabolic process protein metabolic process macromolecule metabolic process regulation of biological quality lipid modification lipid oxidation	extracellular region cellular anatomical entity protein-containing complex plasma lipoprotein particle high-density lipoprotein particle extracellular space lipoprotein particle protein-lipid complex low-density lipoprotein particle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR029058	Alpha/Beta hydrolase fold	Homologous Superfamily
A, B	IPR016715	Platelet-activating factor acetylhydrolase-like, eukaryote	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q13093	platelet-activating factor acetylhydrolase deficiency asthma IgE responsiveness, atopic Hypersensitivity, Immediate coronary artery disease inborn errors of metabolism lung adenocarcinoma non-small cell lung carcinoma schizophrenia ulcerative colitis atopic eczema chronic obstructive pulmonary disease cutaneous lupus erythematosus interstitial cystitis lung carcinoma platelet-activating factor acetylhydrolase deficiency asthma IgE responsiveness, atopic Hypersensitivity, Immediate coronary artery disease inborn errors of metabolism lung adenocarcinoma non-small cell lung carcinoma schizophrenia ulcerative colitis atopic eczema chronic obstructive pulmonary disease cutaneous lupus erythematosus interstitial cystitis lung carcinoma obesity disorder psoriasis Sjogren syndrome ductal breast carcinoma in situ IgA glomerulonephritis invasive ductal breast carcinoma nasopharyngeal carcinoma pilocytic astrocytoma sarcoidosis tuberculosis atherosclerosis cerebrovascular disorder head and neck cancer inherited susceptibility to asthma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.