3G4H

Crystal structure of Human Senescence Marker Protein-30 (Zinc Bound)

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B [auth A]	SCOP2B Superfamily	Calcium-dependent phosphotriesterase	8099180	3000504	SCOP2B (2022-06-29)
A [auth B]	SCOP2B Superfamily	Calcium-dependent phosphotriesterase	8099180	3000504	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B [auth A]	SGL	e3g4hA1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: SGL	ECOD (1.6)
A [auth B]	SGL	e3g4hB1	A: beta duplicates or obligate multimers	X: beta-propeller-like	H: beta-propeller	T: 6-bladed	F: SGL	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B [auth A]	2.120.10.30	Mainly Beta	6 Propeller	Neuraminidase	TolB, C-terminal domain	CATH (4.3.0)
A [auth B]	2.120.10.30	Mainly Beta	6 Propeller	Neuraminidase	TolB, C-terminal domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B], B [auth A]	PF08450	SMP-30/Gluconolactonase/LRE-like region (SGL)	SMP-30/Gluconolactonase/LRE-like region	-	Repeat

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B], B [auth A]	Regucalcin	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding enzyme regulator activity molecular function regulator activity hydrolase activity, acting on ester bonds carboxylic ester hydrolase activity hydrolase activity gluconolactonase activity catalytic activity transition metal ion binding cation binding ion binding binding calcium ion binding metal ion binding small molecule binding enzyme regulator activity molecular function regulator activity hydrolase activity, acting on ester bonds carboxylic ester hydrolase activity hydrolase activity gluconolactonase activity catalytic activity transition metal ion binding zinc ion binding	developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation regulation of biological process regulation of cellular process negative regulation of programmed cell death regulation of apoptotic process biological regulation negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process cellular process apoptotic process programmed cell death cellular biosynthetic process regulation of DNA biosynthetic process negative regulation of cellular metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process nucleic acid biosynthetic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process negative regulation of macromolecule metabolic process regulation of biosynthetic process negative regulation of metabolic process cellular metabolic process primary metabolic process regulation of cellular metabolic process regulation of macromolecule metabolic process DNA metabolic process nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process negative regulation of cellular biosynthetic process regulation of cellular biosynthetic process biosynthetic process negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of DNA metabolic process metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process DNA biosynthetic process negative regulation of DNA biosynthetic process regulation of DNA metabolic process catabolic process macromolecule catabolic process regulation of DNA catabolic process DNA catabolic process negative regulation of catabolic process regulation of catabolic process nucleobase-containing compound catabolic process negative regulation of DNA catabolic process nucleic acid catabolic process multicellular organismal process regulation of multicellular organismal development negative regulation of bone development regulation of developmental process negative regulation of developmental process animal organ development regulation of bone development multicellular organism development skeletal system development anatomical structure development regulation of multicellular organismal process negative regulation of multicellular organismal process bone development system development regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process negative regulation of protein modification process protein metabolic process protein modification process phosphorus metabolic process negative regulation of protein metabolic process protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of protein phosphorylation macromolecule modification negative regulation of phosphorus metabolic process regulation of phosphorylation regulation of phosphorus metabolic process negative regulation of phosphorylation oxoacid metabolic process regulation of lipid metabolic process positive regulation of biological process lipid biosynthetic process positive regulation of cellular metabolic process organic acid biosynthetic process organic acid metabolic process carboxylic acid biosynthetic process positive regulation of fatty acid biosynthetic process positive regulation of metabolic process cellular ketone metabolic process positive regulation of biosynthetic process regulation of small molecule metabolic process positive regulation of lipid metabolic process small molecule metabolic process positive regulation of cellular process positive regulation of fatty acid metabolic process fatty acid metabolic process regulation of cellular ketone metabolic process monocarboxylic acid biosynthetic process small molecule biosynthetic process carboxylic acid metabolic process fatty acid biosynthetic process positive regulation of lipid biosynthetic process cellular lipid metabolic process regulation of fatty acid metabolic process regulation of fatty acid biosynthetic process monocarboxylic acid metabolic process regulation of lipid biosynthetic process positive regulation of small molecule metabolic process positive regulation of cellular biosynthetic process lipid metabolic process positive regulation of protein metabolic process proteolysis involved in protein catabolic process regulation of proteolysis regulation of proteolysis involved in protein catabolic process proteolysis positive regulation of macromolecule metabolic process protein catabolic process positive regulation of proteolysis involved in protein catabolic process positive regulation of proteolysis inorganic ion homeostasis intracellular calcium ion homeostasis homeostatic process calcium ion homeostasis cellular homeostasis chemical homeostasis intracellular monoatomic cation homeostasis monoatomic ion homeostasis intracellular chemical homeostasis monoatomic cation homeostasis intracellular monoatomic ion homeostasis gland development animal organ regeneration liver development regeneration hepaticobiliary system development liver regeneration negative regulation of locomotion regulation of cell motility regulation of reproductive process regulation of cilium-dependent cell motility cilium or flagellum-dependent cell motility regulation of flagellated sperm motility negative regulation of cilium movement cilium-dependent cell motility cell motility locomotion sperm motility regulation of microtubule-based process negative regulation of cilium-dependent cell motility regulation of microtubule-based movement cilium movement involved in cell motility regulation of cilium movement negative regulation of reproductive process regulation of locomotion flagellated sperm motility negative regulation of cell motility microtubule-based movement microtubule-based process cilium movement regulation of cilium movement involved in cell motility negative regulation of flagellated sperm motility monosaccharide metabolic process vitamin biosynthetic process L-ascorbic acid metabolic process lactone biosynthetic process water-soluble vitamin metabolic process carbohydrate metabolic process water-soluble vitamin biosynthetic process carbohydrate biosynthetic process monosaccharide biosynthetic process vitamin metabolic process lactone metabolic process L-ascorbic acid biosynthetic process regulation of nitric oxide biosynthetic process negative regulation of nitric oxide metabolic process reactive nitrogen species metabolic process nitric oxide metabolic process nitric oxide biosynthetic process negative regulation of nitric oxide biosynthetic process regulation of nitric oxide metabolic process hexose metabolic process positive regulation of glucose metabolic process positive regulation of carbohydrate metabolic process regulation of carbohydrate metabolic process regulation of glucose metabolic process glucose metabolic process neutral lipid metabolic process neutral lipid biosynthetic process regulation of triglyceride metabolic process positive regulation of triglyceride metabolic process acylglycerol biosynthetic process triglyceride metabolic process triglyceride biosynthetic process regulation of triglyceride biosynthetic process positive regulation of triglyceride biosynthetic process glycerolipid biosynthetic process glycerolipid metabolic process acylglycerol metabolic process RNA metabolic process negative regulation of RNA biosynthetic process RNA biosynthetic process regulation of RNA metabolic process regulation of RNA biosynthetic process negative regulation of RNA metabolic process cellular response to stimulus regulation of signaling response to stimulus signaling regulation of signal transduction intracellular signal transduction cell communication regulation of intracellular signal transduction regulation of response to stimulus calcium-mediated signaling intracellular signaling cassette regulation of calcium-mediated signaling regulation of cell communication signal transduction negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation regulation of epithelial cell proliferation epithelial cell proliferation negative regulation of epithelial cell proliferation kidney development renal system development positive regulation of molecular function regulation of molecular function regulation of ATP-dependent activity positive regulation of ATP-dependent activity	intracellular anatomical structure cytoplasm cellular anatomical entity membrane-bounded organelle intracellular organelle organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B], B [auth A]	IPR011042	Six-bladed beta-propeller, TolB-like	Homologous Superfamily
A [auth B], B [auth A]	IPR005511	Senescence marker protein-30 (SMP-30)	Family
A [auth B], B [auth A]	IPR013658	SMP-30/Gluconolactonase/LRE-like region	Domain
A [auth B], B [auth A]	IPR008367	Regucalcin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth B], B [auth A]	Pharos: Q15493	kidney disease Liver Neoplasms, Experimental cirrhosis of liver malignant colon neoplasm non-small cell lung carcinoma adrenal cortex carcinoma pancreatic ductal adenocarcinoma breast cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia intellectual disability large cell medulloblastoma lung adenocarcinoma malignant pancreatic neoplasm oligodendroglioma astrocytic tumor kidney disease Liver Neoplasms, Experimental cirrhosis of liver malignant colon neoplasm non-small cell lung carcinoma adrenal cortex carcinoma pancreatic ductal adenocarcinoma breast cancer pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia intellectual disability large cell medulloblastoma lung adenocarcinoma malignant pancreatic neoplasm oligodendroglioma astrocytic tumor pancreatic intraductal papillary-mucinous carcinoma breast carcinoma primitive neuroectodermal tumor drug-induced liver injury invasive ductal breast carcinoma lung cancer medulloblastoma ovarian cancer atypical teratoid rhabdoid tumor pancreatic intraductal papillary-mucinous neoplasm ductal breast carcinoma in situ

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.