Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad3h3fa1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains LDH N-terminal domain-like automated matches (Oryctolagus cuniculus ) [TaxId: 9986 ], SCOPe (2.08)
Ad3h3fa2 Alpha and beta proteins (a+b) LDH C-terminal domain-like LDH C-terminal domain-like Lactate & malate dehydrogenases, C-terminal domain automated matches (Oryctolagus cuniculus ) [TaxId: 9986 ], SCOPe (2.08)
Bd3h3fb1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains LDH N-terminal domain-like automated matches (Oryctolagus cuniculus ) [TaxId: 9986 ], SCOPe (2.08)
Bd3h3fb2 Alpha and beta proteins (a+b) LDH C-terminal domain-like LDH C-terminal domain-like Lactate & malate dehydrogenases, C-terminal domain automated matches (Oryctolagus cuniculus ) [TaxId: 9986 ], SCOPe (2.08)
Cd3h3fc1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains LDH N-terminal domain-like automated matches (Oryctolagus cuniculus ) [TaxId: 9986 ], SCOPe (2.08)
Cd3h3fc2 Alpha and beta proteins (a+b) LDH C-terminal domain-like LDH C-terminal domain-like Lactate & malate dehydrogenases, C-terminal domain automated matches (Oryctolagus cuniculus ) [TaxId: 9986 ], SCOPe (2.08)
Dd3h3fd1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains LDH N-terminal domain-like automated matches (Oryctolagus cuniculus ) [TaxId: 9986 ], SCOPe (2.08)
Dd3h3fd2 Alpha and beta proteins (a+b) LDH C-terminal domain-like LDH C-terminal domain-like Lactate & malate dehydrogenases, C-terminal domain automated matches (Oryctolagus cuniculus ) [TaxId: 9986 ], SCOPe (2.08)
Ed3h3fe1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains LDH N-terminal domain-like automated matches (Oryctolagus cuniculus ) [TaxId: 9986 ], SCOPe (2.08)
Ed3h3fe2 Alpha and beta proteins (a+b) LDH C-terminal domain-like LDH C-terminal domain-like Lactate & malate dehydrogenases, C-terminal domain automated matches (Oryctolagus cuniculus ) [TaxId: 9986 ], SCOPe (2.08)
Fd3h3ff1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains LDH N-terminal domain-like automated matches (Oryctolagus cuniculus ) [TaxId: 9986 ], SCOPe (2.08)
Fd3h3ff2 Alpha and beta proteins (a+b) LDH C-terminal domain-like LDH C-terminal domain-like Lactate & malate dehydrogenases, C-terminal domain automated matches (Oryctolagus cuniculus ) [TaxId: 9986 ], SCOPe (2.08)
Gd3h3fg1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains LDH N-terminal domain-like automated matches (Oryctolagus cuniculus ) [TaxId: 9986 ], SCOPe (2.08)
Gd3h3fg2 Alpha and beta proteins (a+b) LDH C-terminal domain-like LDH C-terminal domain-like Lactate & malate dehydrogenases, C-terminal domain automated matches (Oryctolagus cuniculus ) [TaxId: 9986 ], SCOPe (2.08)
Hd3h3fh1 Alpha and beta proteins (a/b) NAD(P)-binding Rossmann-fold domains NAD(P)-binding Rossmann-fold domains LDH N-terminal domain-like automated matches (Oryctolagus cuniculus ) [TaxId: 9986 ], SCOPe (2.08)
Hd3h3fh2 Alpha and beta proteins (a+b) LDH C-terminal domain-like LDH C-terminal domain-like Lactate & malate dehydrogenases, C-terminal domain automated matches (Oryctolagus cuniculus ) [TaxId: 9986 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyLDH/MDH/AglA-like 8059700 3000039 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyLDH/MDH/AglA-like 8059700 3000039 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyLDH/MDH/AglA-like 8059700 3000039 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyLDH/MDH/AglA-like 8059700 3000039 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyLDH/MDH/AglA-like 8059700 3000039 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyLDH/MDH/AglA-like 8059700 3000039 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyLDH/MDH/AglA-like 8059700 3000039 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyLDH/MDH/AglA-like 8059700 3000039 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ALdh_1_C_13e3h3fA3 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_13ECOD (1.6)
ALdh_1_Ne3h3fA2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)
BLdh_1_C_13e3h3fB1 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_13ECOD (1.6)
BLdh_1_Ne3h3fB2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)
CLdh_1_C_13e3h3fC1 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_13ECOD (1.6)
CLdh_1_Ne3h3fC2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)
DLdh_1_C_13e3h3fD3 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_13ECOD (1.6)
DLdh_1_Ne3h3fD2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)
ELdh_1_C_13e3h3fE3 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_13ECOD (1.6)
ELdh_1_Ne3h3fE2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)
FLdh_1_C_13e3h3fF1 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_13ECOD (1.6)
FLdh_1_Ne3h3fF2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)
GLdh_1_C_13e3h3fG1 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_13ECOD (1.6)
GLdh_1_Ne3h3fG2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)
HLdh_1_C_13e3h3fH1 A: a+b complex topologyX: LDH C-terminal domain-like (From Topology)H: LDH C-terminal domain-like (From Topology)T: LDH C-terminal domain-likeF: Ldh_1_C_13ECOD (1.6)
HLdh_1_Ne3h3fH2 A: a/b three-layered sandwichesX: Rossmann-likeH: Rossmann-relatedT: NAD(P)-binding Rossmann-fold domainsF: Ldh_1_NECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like DomainCATH (4.3.0)
A3.90.110.10 Alpha Beta Alpha-Beta Complex L-2-Hydroxyisocaproate Dehydrogenase Chain A, domain 2CATH (4.3.0)
B3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like DomainCATH (4.3.0)
B3.90.110.10 Alpha Beta Alpha-Beta Complex L-2-Hydroxyisocaproate Dehydrogenase Chain A, domain 2CATH (4.3.0)
C3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like DomainCATH (4.3.0)
C3.90.110.10 Alpha Beta Alpha-Beta Complex L-2-Hydroxyisocaproate Dehydrogenase Chain A, domain 2CATH (4.3.0)
D3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like DomainCATH (4.3.0)
D3.90.110.10 Alpha Beta Alpha-Beta Complex L-2-Hydroxyisocaproate Dehydrogenase Chain A, domain 2CATH (4.3.0)
E3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like DomainCATH (4.3.0)
E3.90.110.10 Alpha Beta Alpha-Beta Complex L-2-Hydroxyisocaproate Dehydrogenase Chain A, domain 2CATH (4.3.0)
F3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like DomainCATH (4.3.0)
F3.90.110.10 Alpha Beta Alpha-Beta Complex L-2-Hydroxyisocaproate Dehydrogenase Chain A, domain 2CATH (4.3.0)
G3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like DomainCATH (4.3.0)
G3.90.110.10 Alpha Beta Alpha-Beta Complex L-2-Hydroxyisocaproate Dehydrogenase Chain A, domain 2CATH (4.3.0)
H3.40.50.720 Alpha Beta 3-Layer(aba) Sandwich Rossmann fold NAD(P)-binding Rossmann-like DomainCATH (4.3.0)
H3.90.110.10 Alpha Beta Alpha-Beta Complex L-2-Hydroxyisocaproate Dehydrogenase Chain A, domain 2CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF02866lactate/malate dehydrogenase, alpha/beta C-terminal domain (Ldh_1_C)lactate/malate dehydrogenase, alpha/beta C-terminal domainL-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the in ...L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes.
Domain
A, B, C, D, E
PF00056lactate/malate dehydrogenase, NAD binding domain (Ldh_1_N)lactate/malate dehydrogenase, NAD binding domainL-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the in ...L-lactate dehydrogenases are metabolic enzymes which catalyse the conversion of L-lactate to pyruvate, the last step in anaerobic glycolysis. L-2-hydroxyisocaproate dehydrogenases are also members of the family. Malate dehydrogenases catalyse the interconversion of malate to oxaloacetate. The enzyme participates in the citric acid cycle. L-lactate dehydrogenase is also found as a lens crystallin in bird and crocodile eyes. N-terminus (this family) is a Rossmann NAD-binding fold. C-terminus is an unusual alpha+beta fold.
Domain

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR011304L-lactate dehydrogenaseFamily
A, B, C, D, E
IPR018177L-lactate dehydrogenase, active siteActive Site
A, B, C, D, E
IPR001236Lactate/malate dehydrogenase, N-terminalDomain
A, B, C, D, E
IPR036291NAD(P)-binding domain superfamilyHomologous Superfamily
A, B, C, D, E
IPR015955Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminalHomologous Superfamily
A, B, C, D, E
IPR022383Lactate/malate dehydrogenase, C-terminalDomain
A, B, C, D, E
IPR001557L-lactate/malate dehydrogenaseFamily