Annotations: 3HNC

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	ATP-cone_1	e3hncB4	A: alpha arrays	X: RuvA-C	H: ATP cone (From Topology)	T: ATP cone	F: ATP-cone_1	ECOD (1.6)
B	Ribonuc_red_lgN	e3hncB3	A: alpha arrays	X: Alpha helical domain of ribonucleotide reductases (From Topology)	H: Alpha helical domain of ribonucleotide reductases (From Topology)	T: Alpha helical domain of ribonucleotide reductases	F: Ribonuc_red_lgN	ECOD (1.6)
B	Ribonuc_red_lgC	e3hncB2	A: a/b barrels	X: Ten stranded beta/alpha barrel (From Topology)	H: Ten stranded beta/alpha barrel (From Topology)	T: Ten stranded beta/alpha barrel	F: Ribonuc_red_lgC	ECOD (1.6)
A	ATP-cone_1	e3hncA1	A: alpha arrays	X: RuvA-C	H: ATP cone (From Topology)	T: ATP cone	F: ATP-cone_1	ECOD (1.6)
A	Ribonuc_red_lgN	e3hncA3	A: alpha arrays	X: Alpha helical domain of ribonucleotide reductases (From Topology)	H: Alpha helical domain of ribonucleotide reductases (From Topology)	T: Alpha helical domain of ribonucleotide reductases	F: Ribonuc_red_lgN	ECOD (1.6)
A	Ribonuc_red_lgC	e3hncA2	A: a/b barrels	X: Ten stranded beta/alpha barrel (From Topology)	H: Ten stranded beta/alpha barrel (From Topology)	T: Ten stranded beta/alpha barrel	F: Ribonuc_red_lgC	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.20.70.20	Alpha Beta	Alpha-Beta Barrel	Anaerobic Ribonucleotide-triphosphate Reductase Large Chain		CATH (4.3.0)
A	3.20.70.20	Alpha Beta	Alpha-Beta Barrel	Anaerobic Ribonucleotide-triphosphate Reductase Large Chain		CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF02867	Ribonucleotide reductase, barrel domain (Ribonuc_red_lgC)	Ribonucleotide reductase, barrel domain	-	Family
A, B	PF00317	Ribonucleotide reductase, all-alpha domain (Ribonuc_red_lgN)	Ribonucleotide reductase, all-alpha domain	-	Domain
A, B	PF03477	ATP cone domain (ATP-cone)	ATP cone domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Ribonucleoside-diphosphate reductase large subunit	ribonucleoside-diphosphate reductase activity oxidoreductase activity oxidoreductase activity, acting on CH or CH2 groups oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor catalytic activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding ribonucleoside-diphosphate reductase activity oxidoreductase activity oxidoreductase activity, acting on CH or CH2 groups oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor catalytic activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding disordered domain specific binding protein binding protein domain specific binding identical protein binding	developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development developmental process multicellular organismal process gonad development reproductive system development reproductive process sex differentiation animal organ development developmental process involved in reproduction male gonad development male sex differentiation multicellular organism development development of primary male sexual characteristics development of primary sexual characteristics anatomical structure development reproductive structure development system development protein-containing complex organization protein heterotetramerization cellular component organization cellular component biogenesis cellular component assembly protein complex oligomerization protein tetramerization protein-containing complex assembly cellular process cellular component organization or biogenesis protein heterooligomerization positive regulation of G0 to G1 transition regulation of biological process regulation of cellular process regulation of cell cycle process biological regulation positive regulation of biological process G0 to G1 transition positive regulation of cell cycle regulation of G0 to G1 transition positive regulation of cell cycle process cell cycle regulation of cell cycle positive regulation of cellular process cell cycle process sensory organ development eye development retina development in camera-type eye visual system development camera-type eye development sensory system development nucleoside phosphate metabolic process primary metabolic process nucleobase-containing compound metabolic process nucleoside diphosphate metabolic process organophosphate metabolic process nucleobase-containing small molecule metabolic process ribonucleoside diphosphate metabolic process phosphate-containing compound metabolic process metabolic process small molecule metabolic process phosphorus metabolic process DNA-templated DNA replication DNA metabolic process mitochondrial genome maintenance nucleic acid metabolic process mitochondrial DNA metabolic process organelle organization DNA replication mitochondrial DNA replication macromolecule metabolic process mitochondrion organization deoxyribose phosphate biosynthetic process nucleotide biosynthetic process carbohydrate derivative metabolic process deoxyribonucleotide biosynthetic process deoxyribonucleotide metabolic process carbohydrate derivative biosynthetic process 2'-deoxyribonucleotide metabolic process 2'-deoxyribonucleotide biosynthetic process nucleotide metabolic process deoxyribose phosphate metabolic process nucleobase-containing compound biosynthetic process biosynthetic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process regulation of cell cycle phase transition cell cycle phase transition regulation of cell cycle G1/S phase transition cell cycle G1/S phase transition mitotic cell cycle regulation of mitotic cell cycle positive regulation of mitotic cell cycle phase transition positive regulation of mitotic cell cycle positive regulation of G1/S transition of mitotic cell cycle regulation of mitotic cell cycle phase transition positive regulation of cell cycle G1/S phase transition mitotic cell cycle process regulation of G1/S transition of mitotic cell cycle positive regulation of cell cycle phase transition G1/S transition of mitotic cell cycle mitotic cell cycle phase transition response to ionizing radiation response to stimulus response to radiation response to abiotic stimulus cell proliferation in forebrain head development cell population proliferation forebrain development brain development nervous system development central nervous system development neural precursor cell proliferation cellular response to stimulus cellular response to stress DNA damage response response to stress DNA repair pyrimidine nucleobase metabolic process pyrimidine-containing compound metabolic process nucleobase metabolic process DNA synthesis involved in DNA repair macromolecule biosynthetic process nucleic acid biosynthetic process DNA biosynthetic process G2/M transition of mitotic cell cycle cell cycle G2/M phase transition positive regulation of G2/M transition of mitotic cell cycle regulation of G2/M transition of mitotic cell cycle regulation of cell cycle G2/M phase transition positive regulation of cell cycle G2/M phase transition	membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle protein-containing complex catalytic complex oxidoreductase complex cytosol ribonucleoside-diphosphate reductase complex organelle envelope membrane-bounded organelle intracellular organelle cellular anatomical structure intracellular anatomical structure mitochondrion organelle cytoplasm intracellular membrane-bounded organelle protein-containing complex catalytic complex oxidoreductase complex cytosol ribonucleoside-diphosphate reductase complex organelle envelope nuclear envelope nucleus endomembrane system somatodendritic compartment cell body neuronal cell body cell projection

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR005144	ATP-cone domain	Domain
A, B	IPR013346	Ribonucleotide reductase, class I, alpha subunit, C-terminal	Domain
A, B	IPR000788	Ribonucleotide reductase large subunit, C-terminal	Domain
A, B	IPR039718	Ribonucleoside-diphosphate reductase large subunit	Family
A, B	IPR013509	Ribonucleotide reductase large subunit, N-terminal	Domain
A, B	IPR008926	Ribonucleotide reductase R1 subunit, N-terminal	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P23921	non-small cell lung carcinoma adrenal cortex carcinoma lung adenocarcinoma neural tube defect ovarian cancer iniencephaly malignant ependymoma medulloblastoma Acrania adrenal carcinoma breast cancer dermatomyositis peripheral nervous system disease psoriasis subependymal giant cell astrocytoma non-small cell lung carcinoma adrenal cortex carcinoma lung adenocarcinoma neural tube defect ovarian cancer iniencephaly malignant ependymoma medulloblastoma Acrania adrenal carcinoma breast cancer dermatomyositis peripheral nervous system disease psoriasis subependymal giant cell astrocytoma tuberculosis large cell medulloblastoma lung cancer malignant glioma melanoma acute lymphoblastic leukemia oligodendroglioma chronic myelogenous leukemia, BCR-ABL1 positive pancreatic adenocarcinoma diastematomyelia peripheral neuropathy sickle cell anemia Gaucher disease hepatocellular carcinoma lymphoplasmacytic lymphoma neurenteric cyst atypical teratoid rhabdoid tumor osteosarcoma craniorachischisis pancreatic intraductal papillary-mucinous neoplasm primitive neuroectodermal tumor endometriosis glioblastoma tethered spinal cord syndrome

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.