3HOH

RIBONUCLEASE T1 (THR93GLN MUTANT) COMPLEXED WITH 2'GMP

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3hoha_	Alpha and beta proteins (a+b)	Microbial ribonucleases	Microbial ribonucleases	Fungal ribonucleases	RNase T1	(Aspergillus oryzae ) [TaxId: 5062 ],	SCOPe (2.08)
B	d3hohb_	Alpha and beta proteins (a+b)	Microbial ribonucleases	Microbial ribonucleases	Fungal ribonucleases	RNase T1	(Aspergillus oryzae ) [TaxId: 5062 ],	SCOPe (2.08)
C	d3hohc_	Alpha and beta proteins (a+b)	Microbial ribonucleases	Microbial ribonucleases	Fungal ribonucleases	RNase T1	(Aspergillus oryzae ) [TaxId: 5062 ],	SCOPe (2.08)
D	d3hohd_	Alpha and beta proteins (a+b)	Microbial ribonucleases	Microbial ribonucleases	Fungal ribonucleases	RNase T1	(Aspergillus oryzae ) [TaxId: 5062 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Microbial ribonucleases	8033542	3001847	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Microbial ribonucleases	8033542	3001847	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Microbial ribonucleases	8033542	3001847	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Microbial ribonucleases	8033542	3001847	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Ribonuclease	e3hohA1	A: a+b two layers	X: Microbial ribonucleases-like	H: Microbial ribonucleases (From Topology)	T: Microbial ribonucleases	F: Ribonuclease	ECOD (1.6)
B	Ribonuclease	e3hohB1	A: a+b two layers	X: Microbial ribonucleases-like	H: Microbial ribonucleases (From Topology)	T: Microbial ribonucleases	F: Ribonuclease	ECOD (1.6)
C	Ribonuclease	e3hohC1	A: a+b two layers	X: Microbial ribonucleases-like	H: Microbial ribonucleases (From Topology)	T: Microbial ribonucleases	F: Ribonuclease	ECOD (1.6)
D	Ribonuclease	e3hohD1	A: a+b two layers	X: Microbial ribonucleases-like	H: Microbial ribonucleases (From Topology)	T: Microbial ribonucleases	F: Ribonuclease	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.450.30	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
B	3.10.450.30	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
C	3.10.450.30	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)
D	3.10.450.30	Alpha Beta	Roll	Nuclear Transport Factor 2	Chain: A,	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00545	ribonuclease (Ribonuclease)	ribonuclease	This enzyme hydrolyses RNA and oligoribonucleotides.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	PROTEIN (RIBONUCLEASE T1)	endonuclease activity nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on RNA RNA endonuclease activity catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity ribonuclease T1 activity lyase activity RNA binding binding organic cyclic compound binding endonuclease activity nuclease activity hydrolase activity, acting on ester bonds catalytic activity, acting on RNA RNA endonuclease activity catalytic activity, acting on a nucleic acid RNA nuclease activity hydrolase activity catalytic activity ribonuclease T1 activity lyase activity RNA binding binding organic cyclic compound binding nucleic acid binding	-	cell tip cell pole cellular anatomical entity hyphal tip site of polarized growth cell septum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR000026	Guanine-specific ribonuclease N1-like	Family
A, B, C, D	IPR051386	Guanyl-specific ribonuclease N1/T1	Family
A, B, C, D	IPR016191	Ribonuclease/ribotoxin	Homologous Superfamily
A, B, C, D	IPR048269	Ribonuclease ribotoxin, alpha-sarcin type	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.