Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ADNA_pol_A_2nde3hpoA1 A: alpha arraysX: helical bundle in Bacillus stearothermophilus-like DNA polymerase I (From Topology)H: helical bundle in Bacillus stearothermophilus-like DNA polymerase I (From Topology)T: helical bundle in Bacillus stearothermophilus-like DNA polymerase IF: DNA_pol_A_2ndECOD (1.6)
ADNA_pol_A_1ste3hpoA2 A: alpha bundlesX: fingers domain in bacteriophage RB69-like DNA polymerase I (From Topology)H: fingers domain in bacteriophage RB69-like DNA polymerase I (From Topology)T: fingers domain in bacteriophage RB69-like DNA polymerase IF: DNA_pol_A_1stECOD (1.6)
ADNA_pol_A_3rde3hpoA3 A: a+b two layersX: Alpha-beta plaitsH: Adenylyl and guanylyl cyclase catalytic domain-likeT: Adenylyl and guanylyl cyclase catalytic domain-likeF: DNA_pol_A_3rdECOD (1.6)
ADNA_pol_A_exo1_1e3hpoA4 A: mixed a+b and a/bX: Ribonuclease H-likeH: Ribonuclease H-like (From Topology)T: Ribonuclease H-likeF: DNA_pol_A_exo1_1ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.30.420.10 Alpha Beta 2-Layer Sandwich Nucleotidyltransferase domain 5CATH (4.3.0)
A1.20.1060.10 Mainly Alpha Up-down Bundle Taq DNA Polymerase Chain T, domain 4CATH (4.3.0)
A3.30.70.370 Alpha Beta 2-Layer Sandwich Alpha-Beta Plaits CATH (4.3.0)
A1.10.150.20 Mainly Alpha Orthogonal Bundle DNA polymerase domain 1CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF22619DNA polymerase I, ribonuclease H-like domain (DNA_polI_exo1)DNA polymerase I, ribonuclease H-like domainThis domain is responsible for the 3'-5' exonuclease proofreading activity of E. coli DNA polymerase I (polI) and other related enzymes. It is one of the constituent domains of Klenow fragment.Domain
PF00476DNA polymerase family A (DNA_pol_A)DNA polymerase family A- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
DNA polymerase I, large fragment -
5'-D(*CP*GP*AP*TP*CP*AP*CP*GP*(DOC))-3'---
5'-D(P*GP*GP*CP*GP*TP*GP*AP*TP*CP*G)-3'---