3HQQ

Crystal structure of Leishmania mexicana pyruvate kinase (LmPYK) in complex with Fructose 2,6 bisphosphate

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
Q	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
Q	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
Q	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
Q	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
R	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
R	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
R	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
R	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
S	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
S	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
S	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
S	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
T	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
T	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
T	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
T	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
U	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
U	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
U	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
U	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
V	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
V	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
V	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
V	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
W	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
W	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
W	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
W	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
X	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)
X	SCOP2B Superfamily	PK beta-barrel domain-like	8042557	3001296	SCOP2B (2022-06-29)
X	SCOP2B Superfamily	PK C-terminal domain-like	8044406	3000442	SCOP2B (2022-06-29)
X	SCOP2B Superfamily	Phosphoenolpyruvate/pyruvate domain	8043649	3000510	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PK_2nd	e3hqqA4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
A	PK_1st	e3hqqA2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
A	PK_C	e3hqqA1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
B	PK_2nd	e3hqqB4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
B	PK_1st	e3hqqB2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
B	PK_C	e3hqqB1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
C	PK_2nd	e3hqqC4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
C	PK_1st	e3hqqC2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
C	PK_C	e3hqqC1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
D	PK_2nd	e3hqqD4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
D	PK_1st	e3hqqD2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
D	PK_C	e3hqqD1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
E	PK_2nd	e3hqqE4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
E	PK_1st	e3hqqE2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
E	PK_C	e3hqqE1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
F	PK_2nd	e3hqqF4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
F	PK_1st	e3hqqF2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
F	PK_C	e3hqqF1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
G	PK_2nd	e3hqqG4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
G	PK_1st	e3hqqG2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
G	PK_C	e3hqqG1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
H	PK_2nd	e3hqqH4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
H	PK_1st	e3hqqH2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
H	PK_C	e3hqqH1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
I	PK_2nd	e3hqqI4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
I	PK_1st	e3hqqI2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
I	PK_C	e3hqqI1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
J	PK_2nd	e3hqqJ4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
J	PK_1st	e3hqqJ2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
J	PK_C	e3hqqJ1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
K	PK_2nd	e3hqqK4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
K	PK_1st	e3hqqK2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
K	PK_C	e3hqqK1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
L	PK_2nd	e3hqqL4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
L	PK_1st	e3hqqL2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
L	PK_C	e3hqqL1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
M	PK_2nd	e3hqqM4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
M	PK_1st	e3hqqM2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
M	PK_C	e3hqqM1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
N	PK_2nd	e3hqqN4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
N	PK_1st	e3hqqN2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
N	PK_C	e3hqqN1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
O	PK_2nd	e3hqqO4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
O	PK_1st	e3hqqO2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
O	PK_C	e3hqqO1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
P	PK_2nd	e3hqqP4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
P	PK_1st	e3hqqP2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
P	PK_C	e3hqqP1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
Q	PK_2nd	e3hqqQ4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
Q	PK_1st	e3hqqQ2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
Q	PK_C	e3hqqQ1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
R	PK_2nd	e3hqqR4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
R	PK_1st	e3hqqR2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
R	PK_C	e3hqqR1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
S	PK_2nd	e3hqqS4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
S	PK_1st	e3hqqS2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
S	PK_C	e3hqqS1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
T	PK_2nd	e3hqqT4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
T	PK_1st	e3hqqT2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
T	PK_C	e3hqqT1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
U	PK_2nd	e3hqqU4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
U	PK_1st	e3hqqU2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
U	PK_C	e3hqqU1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
V	PK_2nd	e3hqqV4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
V	PK_1st	e3hqqV2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
V	PK_C	e3hqqV1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
W	PK_2nd	e3hqqW4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
W	PK_1st	e3hqqW2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
W	PK_C	e3hqqW1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)
X	PK_2nd	e3hqqX4	A: beta barrels	X: cradle loop barrel	H: RIFT-related	T: PK beta-barrel domain-like	F: PK_2nd	ECOD (1.6)
X	PK_1st	e3hqqX2	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: PK_1st	ECOD (1.6)
X	PK_C	e3hqqX1	A: a/b three-layered sandwiches	X: PK C-terminal domain-like (From Topology)	H: PK C-terminal domain-like (From Topology)	T: PK C-terminal domain-like	F: PK_C	ECOD (1.6)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	PF00224	Pyruvate kinase, barrel domain (PK)	Pyruvate kinase, barrel domain	This is the barrel domain of pyruvate kinases. This domain represents the beta/alpha barrel and the small beta-barrel domain inserted within it. The active site is found in a cleft between the two domains [1,2,3,4].	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	PF02887	Pyruvate kinase, alpha/beta domain (PK_C)	Pyruvate kinase, alpha/beta domain	Pyruvate kinase catalyses the final step in glycolysis, the conversion of phosphoenolpyruvate to pyruvate with concomitant phosphorylation of ADP to ATP [1,2]. The structure of several pyruvate kinases from various organisms have been determined [2, ...	Pyruvate kinase catalyses the final step in glycolysis, the conversion of phosphoenolpyruvate to pyruvate with concomitant phosphorylation of ADP to ATP [1,2]. The structure of several pyruvate kinases from various organisms have been determined [2, 3,4]. The protein comprises three-four domains: a small N-terminal helical domain (absent in bacterial PK), a beta/alpha barrel domain, a beta-barrel domain (inserted within the beta/alpha-barrel domain), and a 3-layer alpha/beta/alpha sandwich domain (represented in this entry). This domain is at the C-terminal of pyruvate kinases and contains the FBP (fructose 1,6-bisphosphate) binding site [2,4,5].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	Pyruvate kinase	cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding cation binding magnesium ion binding ion binding binding metal ion binding small molecule binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding potassium ion binding alkali metal ion binding kinase activity transferase activity catalytic activity transferase activity, transferring phosphorus-containing groups pyruvate kinase activity phosphotransferase activity, alcohol group as acceptor	cellular response to stimulus cellular response to nitrogen compound response to stimulus response to endogenous stimulus response to organonitrogen compound response to peptide hormone response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to organonitrogen compound response to hormone response to chemical cellular response to stimulus cellular response to nitrogen compound response to stimulus response to endogenous stimulus response to organonitrogen compound response to peptide hormone response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to endogenous stimulus cellular response to chemical stimulus cellular response to organonitrogen compound response to hormone response to chemical response to insulin cellular process cellular response to insulin stimulus cellular response to hormone stimulus	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	IPR015795	Pyruvate kinase, C-terminal	Domain
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	IPR015813	Pyruvate/Phosphoenolpyruvate kinase-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	IPR011037	Pyruvate kinase-like, insert domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	IPR015806	Pyruvate kinase, insert domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	IPR036918	Pyruvate kinase, C-terminal domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	IPR001697	Pyruvate kinase	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	IPR018209	Pyruvate kinase, active site	Active Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	IPR040442	Pyruvate kinase-like domain superfamily	Homologous Superfamily
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T, U, V, W, X	IPR015793	Pyruvate kinase, barrel	Domain