Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyFlavoproteins 8044090 3001217 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyFlavoproteins 8044090 3001217 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyFlavoproteins 8044090 3001217 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyFlavoproteins 8044090 3001217 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyFlavoproteins 8044090 3001217 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyFlavoproteins 8044090 3001217 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyFlavoproteins 8044090 3001217 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyFlavoproteins 8044090 3001217 SCOP2B (2022-06-29)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF02525Flavodoxin-like fold (Flavodoxin_2)Flavodoxin-like foldThis family consists of a domain with a flavodoxin-like fold. The family includes bacterial and eukaryotic NAD(P)H dehydrogenase (quinone) EC:1.6.99.2. These enzymes catalyse the NAD(P)H-dependent two-electron reductions of quinones and protect cell ...This family consists of a domain with a flavodoxin-like fold. The family includes bacterial and eukaryotic NAD(P)H dehydrogenase (quinone) EC:1.6.99.2. These enzymes catalyse the NAD(P)H-dependent two-electron reductions of quinones and protect cells against damage by free radicals and reactive oxygen species [1]. This enzyme uses a FAD co-factor. The equation for this reaction is:- NAD(P)H + acceptor <=> NAD(P)(+) + reduced acceptor. This enzyme is also involved in the bioactivation of prodrugs used in chemotherapy [1]. The family also includes acyl carrier protein phosphodiesterase EC:3.1.4.14. This enzyme converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine residue from ACP [2]. This family is related to Pfam:PF03358 and Pfam:PF00258.
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
NAD(P)H dehydrogenase [quinone] 1

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR003680Flavodoxin-like foldDomain
A, B, C, D, E
IPR029039Flavoprotein-like superfamilyHomologous Superfamily
A, B, C, D, E
IPR051545NAD(P)H dehydrogenase (quinone)Family

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A, B, C, D, E
PharosP15559