3KNU

Crystal structure of tRNA (guanine-N1)-methyltransferase from Anaplasma phagocytophilum

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
B	d3knub1	Alpha and beta proteins (a/b)	alpha/beta knot	alpha/beta knot	automated matches	automated matches	(Anaplasma phagocytophilum str. HZ ) [TaxId: 212042 ],	SCOPe (2.08)
B	d3knub2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Anaplasma phagocytophilum str. HZ ) [TaxId: 212042 ],	SCOPe (2.08)
C	d3knuc1	Alpha and beta proteins (a/b)	alpha/beta knot	alpha/beta knot	automated matches	automated matches	(Anaplasma phagocytophilum str. HZ ) [TaxId: 212042 ],	SCOPe (2.08)
C	d3knuc2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Anaplasma phagocytophilum str. HZ ) [TaxId: 212042 ],	SCOPe (2.08)
A	d3knua1	Alpha and beta proteins (a/b)	alpha/beta knot	alpha/beta knot	automated matches	automated matches	(Anaplasma phagocytophilum str. HZ ) [TaxId: 212042 ],	SCOPe (2.08)
A	d3knua2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Anaplasma phagocytophilum str. HZ ) [TaxId: 212042 ],	SCOPe (2.08)
D	d3knud_	Alpha and beta proteins (a/b)	alpha/beta knot	alpha/beta knot	automated matches	automated matches	(Anaplasma phagocytophilum str. HZ ) [TaxId: 212042 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	alpha/beta knot	8066647	3001122	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	alpha/beta knot	8066647	3001122	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	alpha/beta knot	8066647	3001122	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	alpha/beta knot	8066647	3001122	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	tRNA_m1G_MT	e3knuB1	A: a/b three-layered sandwiches	X: alpha/beta knot (From Topology)	H: alpha/beta knot (From Topology)	T: alpha/beta knot	F: tRNA_m1G_MT	ECOD (1.6)
C	tRNA_m1G_MT	e3knuC1	A: a/b three-layered sandwiches	X: alpha/beta knot (From Topology)	H: alpha/beta knot (From Topology)	T: alpha/beta knot	F: tRNA_m1G_MT	ECOD (1.6)
A	tRNA_m1G_MT	e3knuA1	A: a/b three-layered sandwiches	X: alpha/beta knot (From Topology)	H: alpha/beta knot (From Topology)	T: alpha/beta knot	F: tRNA_m1G_MT	ECOD (1.6)
D	tRNA_m1G_MT	e3knuD1	A: a/b three-layered sandwiches	X: alpha/beta knot (From Topology)	H: alpha/beta knot (From Topology)	T: alpha/beta knot	F: tRNA_m1G_MT	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.40.1280.10	Alpha Beta	3-Layer(aba) Sandwich	Alpha/beta knot	SPOUT methyltransferase, trefoil knot domain	CATH (4.3.0)
B	1.10.1270.20	Mainly Alpha	Orthogonal Bundle	Trp Operon Repressor	Chain A	CATH (4.3.0)
C	3.40.1280.10	Alpha Beta	3-Layer(aba) Sandwich	Alpha/beta knot	SPOUT methyltransferase, trefoil knot domain	CATH (4.3.0)
C	1.10.1270.20	Mainly Alpha	Orthogonal Bundle	Trp Operon Repressor	Chain A	CATH (4.3.0)
A	3.40.1280.10	Alpha Beta	3-Layer(aba) Sandwich	Alpha/beta knot	SPOUT methyltransferase, trefoil knot domain	CATH (4.3.0)
A	1.10.1270.20	Mainly Alpha	Orthogonal Bundle	Trp Operon Repressor	Chain A	CATH (4.3.0)
D	3.40.1280.10	Alpha Beta	3-Layer(aba) Sandwich	Alpha/beta knot	SPOUT methyltransferase, trefoil knot domain	CATH (4.3.0)
D	1.10.1270.20	Mainly Alpha	Orthogonal Bundle	Trp Operon Repressor	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF01746	tRNA (Guanine-1)-methyltransferase (tRNA_m1G_MT)	tRNA (Guanine-1)-methyltransferase	-	Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	tRNA (guanine-N(1)-)-methyltransferase	tRNA methyltransferase activity RNA methyltransferase activity tRNA (guanine(37)-N1)-methyltransferase activity catalytic activity, acting on RNA transferase activity, transferring one-carbon groups catalytic activity, acting on a nucleic acid tRNA (guanine) methyltransferase activity catalytic activity, acting on a tRNA transferase activity S-adenosylmethionine-dependent methyltransferase activity methyltransferase activity catalytic activity	methylation metabolic process cellular biosynthetic process cellular metabolic process tRNA modification RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process methylation metabolic process cellular biosynthetic process cellular metabolic process tRNA modification RNA metabolic process primary metabolic process gene expression nucleobase-containing compound biosynthetic process macromolecule biosynthetic process nucleic acid metabolic process tRNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process RNA modification biosynthetic process tRNA processing macromolecule modification cellular process macromolecule metabolic process RNA processing	intracellular anatomical structure cytoplasm cellular anatomical entity

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR029026	tRNA (guanine-N1-)-methyltransferase, N-terminal	Homologous Superfamily
A, B, C, D	IPR029028	Alpha/beta knot methyltransferases	Homologous Superfamily
A, B, C, D	IPR016009	tRNA methyltransferase TRMD/TRM10-type domain	Domain
A, B, C, D	IPR023148	tRNA (guanine-N(1)-)-methyltransferase, C-terminal domain superfamily	Homologous Superfamily
A, B, C, D	IPR002649	tRNA (guanine-N1-)-methyltransferase TrmD	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.