Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyPH domain-like 8043804 3000134 SCOP2B (2022-06-29)
ASCOP2B SuperfamilyDBL homology domain (DH-domain) 8043802 3000793 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyPH domain-like 8043804 3000134 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyDBL homology domain (DH-domain) 8043802 3000793 SCOP2B (2022-06-29)
C [auth E]SCOP2B SuperfamilyRas-like P-loop GTPases 8057414 3002022 SCOP2B (2022-06-29)
D [auth F]SCOP2B SuperfamilyRas-like P-loop GTPases 8057414 3002022 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
APH_13_1e3kz1A4 A: beta barrelsX: PH domain-likeH: PH domain-like (From Topology)T: PH domain-likeF: PH_13_1ECOD (1.6)
ARhoGEFe3kz1A3 A: alpha bundlesX: DH domain-likeH: DBL homology domain (DH-domain) (From Topology)T: DBL homology domain (DH-domain)F: RhoGEFECOD (1.6)
BPH_13_1e3kz1B6 A: beta barrelsX: PH domain-likeH: PH domain-like (From Topology)T: PH domain-likeF: PH_13_1ECOD (1.6)
BRhoGEFe3kz1B5 A: alpha bundlesX: DH domain-likeH: DBL homology domain (DH-domain) (From Topology)T: DBL homology domain (DH-domain)F: RhoGEFECOD (1.6)
C [auth E]Rase3kz1E1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)
D [auth F]Rase3kz1F1 A: a/b three-layered sandwichesX: P-loop domains-likeH: P-loop domains-relatedT: P-loop containing nucleoside triphosphate hydrolasesF: RasECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B
PF17838PH domain (PH_16)PH domain- Domain
A, B
PF00621RhoGEF domain (RhoGEF)RhoGEF domainGuanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases Also called Dbl-homologous (DH) domain. It appears that Pfam:PF00169 domains invariably occur C-terminal to RhoGEF/DH domains.Domain
C [auth E],
D [auth F]
PF00071Ras family (Ras)Ras familyIncludes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motil ...Includes sub-families Ras, Rab, Rac, Ral, Ran, Rap Ypt1 and more. Shares P-loop motif with GTP_EFTU, arf and myosin_head. See Pfam:PF00009 Pfam:PF00025, Pfam:PF00063. As regards Rab GTPases, these are important regulators of vesicle formation, motility and fusion. They share a fold in common with all Ras GTPases: this is a six-stranded beta-sheet surrounded by five alpha-helices [1].
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B
Rho guanine nucleotide exchange factor 11
C [auth E],
D [auth F]
Transforming protein RhoA