3L2Y

The structure of C-reactive protein bound to phosphoethanolamine

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3l2ya_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Pentraxin (pentaxin)	C-reactive protein (CRP)	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3l2yb_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Pentraxin (pentaxin)	C-reactive protein (CRP)	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d3l2yc_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Pentraxin (pentaxin)	C-reactive protein (CRP)	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d3l2yd_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Pentraxin (pentaxin)	C-reactive protein (CRP)	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
F	d3l2yf_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Pentraxin (pentaxin)	C-reactive protein (CRP)	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
G	d3l2yg_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Pentraxin (pentaxin)	C-reactive protein (CRP)	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
H	d3l2yh_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Pentraxin (pentaxin)	C-reactive protein (CRP)	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
J	d3l2yj_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Pentraxin (pentaxin)	C-reactive protein (CRP)	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
K	d3l2yk_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Pentraxin (pentaxin)	C-reactive protein (CRP)	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
L	d3l2yl_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Pentraxin (pentaxin)	C-reactive protein (CRP)	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
M	d3l2ym_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Pentraxin (pentaxin)	C-reactive protein (CRP)	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
N	d3l2yn_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Pentraxin (pentaxin)	C-reactive protein (CRP)	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
O	d3l2yo_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Pentraxin (pentaxin)	C-reactive protein (CRP)	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
P	d3l2yp_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Pentraxin (pentaxin)	C-reactive protein (CRP)	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
R	d3l2yr_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Pentraxin (pentaxin)	C-reactive protein (CRP)	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
S	d3l2ys_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Pentraxin (pentaxin)	C-reactive protein (CRP)	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
T	d3l2yt_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Pentraxin (pentaxin)	C-reactive protein (CRP)	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
E	d3l2ye_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Pentraxin (pentaxin)	C-reactive protein (CRP)	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
I	d3l2yi_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Pentraxin (pentaxin)	C-reactive protein (CRP)	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
Q	d3l2yq_	All beta proteins	Concanavalin A-like lectins/glucanases	Concanavalin A-like lectins/glucanases	Pentraxin (pentaxin)	C-reactive protein (CRP)	(Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041434	3000120	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041434	3000120	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041434	3000120	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041434	3000120	SCOP2B (2022-06-29)
F	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041434	3000120	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041434	3000120	SCOP2B (2022-06-29)
H	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041434	3000120	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041434	3000120	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041434	3000120	SCOP2B (2022-06-29)
L	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041434	3000120	SCOP2B (2022-06-29)
M	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041434	3000120	SCOP2B (2022-06-29)
N	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041434	3000120	SCOP2B (2022-06-29)
O	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041434	3000120	SCOP2B (2022-06-29)
P	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041434	3000120	SCOP2B (2022-06-29)
R	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041434	3000120	SCOP2B (2022-06-29)
S	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041434	3000120	SCOP2B (2022-06-29)
T	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041434	3000120	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041434	3000120	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041434	3000120	SCOP2B (2022-06-29)
Q	SCOP2B Superfamily	Concanavalin A-like lectins/glucanases	8041434	3000120	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Pentaxin	e3l2yA1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Pentaxin	ECOD (1.6)
B	Pentaxin	e3l2yB1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Pentaxin	ECOD (1.6)
C	Pentaxin	e3l2yC1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Pentaxin	ECOD (1.6)
D	Pentaxin	e3l2yD1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Pentaxin	ECOD (1.6)
F	Pentaxin	e3l2yF1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Pentaxin	ECOD (1.6)
G	Pentaxin	e3l2yG1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Pentaxin	ECOD (1.6)
H	Pentaxin	e3l2yH1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Pentaxin	ECOD (1.6)
J	Pentaxin	e3l2yJ1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Pentaxin	ECOD (1.6)
K	Pentaxin	e3l2yK1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Pentaxin	ECOD (1.6)
L	Pentaxin	e3l2yL1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Pentaxin	ECOD (1.6)
M	Pentaxin	e3l2yM1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Pentaxin	ECOD (1.6)
N	Pentaxin	e3l2yN1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Pentaxin	ECOD (1.6)
O	Pentaxin	e3l2yO1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Pentaxin	ECOD (1.6)
P	Pentaxin	e3l2yP1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Pentaxin	ECOD (1.6)
R	Pentaxin	e3l2yR1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Pentaxin	ECOD (1.6)
S	Pentaxin	e3l2yS1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Pentaxin	ECOD (1.6)
T	Pentaxin	e3l2yT1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Pentaxin	ECOD (1.6)
E	Pentaxin	e3l2yE1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Pentaxin	ECOD (1.6)
I	Pentaxin	e3l2yI1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Pentaxin	ECOD (1.6)
Q	Pentaxin	e3l2yQ1	A: beta sandwiches	X: jelly-roll	H: Concanavalin A-like	T: Concanavalin A-like lectins/glucanases	F: Pentaxin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Provenance Source (Version)
A	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls	CATH (4.3.0)
B	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls	CATH (4.3.0)
C	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls	CATH (4.3.0)
D	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls	CATH (4.3.0)
F	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls	CATH (4.3.0)
G	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls	CATH (4.3.0)
H	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls	CATH (4.3.0)
J	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls	CATH (4.3.0)
K	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls	CATH (4.3.0)
L	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls	CATH (4.3.0)
M	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls	CATH (4.3.0)
N	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls	CATH (4.3.0)
O	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls	CATH (4.3.0)
P	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls	CATH (4.3.0)
R	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls	CATH (4.3.0)
S	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls	CATH (4.3.0)
T	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls	CATH (4.3.0)
E	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls	CATH (4.3.0)
I	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls	CATH (4.3.0)
Q	2.60.120.200	Mainly Beta	Sandwich	Jelly Rolls	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	PF00354	Pentaxin family (Pentaxin)	Pentaxin family	Pentaxins are also known as pentraxins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	C-reactive protein	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding lipoprotein particle binding protein-containing complex binding protein-lipid complex binding low-density lipoprotein particle binding complement component C1q complex binding opsonin binding protein binding complement binding cation binding ion binding binding calcium ion binding metal ion binding small molecule binding lipoprotein particle binding protein-containing complex binding protein-lipid complex binding low-density lipoprotein particle binding complement component C1q complex binding opsonin binding protein binding complement binding choline binding low-density lipoprotein particle receptor binding signaling receptor binding lipoprotein particle receptor binding identical protein binding	import into cell transport establishment of localization vesicle-mediated transport immune effector process phagocytosis, recognition opsonization localization immune system process phagocytosis cellular process cell recognition endocytosis developmental process import into cell transport establishment of localization vesicle-mediated transport immune effector process phagocytosis, recognition opsonization localization immune system process phagocytosis cellular process cell recognition endocytosis developmental process regulation of biological process regulation of cellular process regulation of developmental process cellular developmental process negative regulation of developmental process macrophage derived foam cell differentiation biological regulation negative regulation of biological process regulation of cell differentiation negative regulation of macrophage derived foam cell differentiation foam cell differentiation cell differentiation negative regulation of cellular process regulation of macrophage derived foam cell differentiation negative regulation of cell differentiation cellular metabolic process reactive oxygen species metabolic process positive regulation of biological process regulation of superoxide metabolic process regulation of cellular metabolic process positive regulation of cellular metabolic process positive regulation of reactive oxygen species metabolic process superoxide metabolic process positive regulation of metabolic process superoxide anion generation metabolic process positive regulation of superoxide anion generation regulation of superoxide anion generation regulation of metabolic process regulation of reactive oxygen species metabolic process positive regulation of cellular process regulation of leukocyte proliferation negative regulation of cell population proliferation cell population proliferation leukocyte proliferation negative regulation of mononuclear cell proliferation negative regulation of leukocyte proliferation regulation of cell population proliferation mononuclear cell proliferation regulation of mononuclear cell proliferation multicellular organismal process cellular biosynthetic process cytokine production regulation of cytokine production regulation of multicellular organismal process regulation of biosynthetic process interleukin-8 production regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of interleukin-8 production acute-phase response response to stimulus defense response response to stress inflammatory response acute inflammatory response positive regulation of macromolecule biosynthetic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of gene expression positive regulation of cellular biosynthetic process regulation of tube diameter system process regulation of tube size circulatory system process vascular process in circulatory system blood vessel diameter maintenance regulation of biological quality vasoconstriction blood circulation regulation of anatomical structure size biological process involved in interspecies interaction between organisms immune response response to other organism defense response to symbiont response to external stimulus response to biotic stimulus defense response to other organism innate immune response response to external biotic stimulus regulation of localization lipid storage lipid localization negative regulation of lipid localization maintenance of location regulation of lipid storage regulation of lipid localization negative regulation of lipid storage macromolecule localization defense response to Gram-positive bacterium defense response to bacterium response to bacterium	extracellular region cellular anatomical entity extracellular space

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	IPR001759	Pentraxin-related	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	IPR030476	Pentaxin, conserved site	Conserved Site
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	IPR051005	Pentraxin domain-containing protein	Family
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	IPR013320	Concanavalin A-like lectin/glucanase domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D, E A, B, C, D, E, F, G, H, I, J, K, L, M, N, O, P, Q, R, S, T	Pharos: P02741	coronary artery disease Crohn disease malaria rheumatoid arthritis periodontitis atherosclerosis heart disease metabolic syndrome X hypertensive disorder obesity disorder leishmaniasis diabetic retinopathy psoriasis cardiovascular disease secondary hyperparathyroidism coronary artery disease Crohn disease malaria rheumatoid arthritis periodontitis atherosclerosis heart disease metabolic syndrome X hypertensive disorder obesity disorder leishmaniasis diabetic retinopathy psoriasis cardiovascular disease secondary hyperparathyroidism myocarditis hypertriglyceridemia acute coronary syndrome Infection thrombotic disease metabolic disease substance withdrawal syndrome systemic lupus erythematosus congestive heart failure infectious meningitis interstitial nephritis chronic kidney disease visceral leishmaniasis major depressive disorder asthma pustulosis palmaris et plantaris exanthem meningitis autoimmune disease rheumatic disorder heart failure mucocutaneous lymph node syndrome hepatocellular carcinoma cerebrovascular disorder syphilis obstructive sleep apnea syndrome chronic obstructive pulmonary disease thrombocytosis disease anemia pancreatic ductal adenocarcinoma inflammatory bowel disease type 1 diabetes mellitus interstitial lung disease appendicitis urinary tract infection kidney disease peripheral neuropathy lung benign neoplasm arthritic joint disease pneumonia diarrheal disease pulmonary embolism drug-induced liver injury pyuria hyperglycemia cholecystitis ileocolitis adult acute respiratory distress syndrome osteomyelitis thrombophilia anxiety disorder pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia COVID-19 influenza pericardial effusion Crohn's colitis type 2 diabetes mellitus vasculitis peripheral vascular disease prediabetes syndrome lymphopenia arthropathy epidural abscess cancer schizophrenia hepatitis B virus infection myocardial ischemia cellulitis synovitis thrombocytopenia inborn carbohydrate metabolic disorder allergic disease pancreatitis COVID-19–associated multisystem inflammatory syndrome in children tuberculosis inherited lipid metabolism disorder aortic disease pericarditis intestinal obstruction peripheral arterial disease liver disease arteriosclerosis disorder peritonitis lupus erythematosus