Annotations: 3LJU

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth X]	PH	e3ljuX5	A: beta barrels	X: PH domain-like	H: PH domain-like (From Topology)	T: PH domain-like	F: PH	ECOD (1.6)
A [auth X]	ArfGap	e3ljuX1	A: few secondary structure elements	X: Glucocorticoid receptor-like	H: LIM domain-like	T: LIM domain-like	F: ArfGap	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth X]	1.10.220.150	Mainly Alpha	Orthogonal Bundle	Annexin V	domain 1	CATH (4.3.0)
A [auth X]	2.30.29.30	Mainly Beta	Roll	PH-domain like	Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB)	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth X]	PF00169	PH domain (PH)	PH domain	PH stands for pleckstrin homology.	Domain
A [auth X]	PF01412	Putative GTPase activating protein for Arf (ArfGap)	Putative GTPase activating protein for Arf	Putative zinc fingers with GTPase activating proteins (GAPs) towards the small GTPase, Arf. The GAP of ARD1 stimulates GTPase hydrolysis for ARD1 but not ARFs.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth X]	Arf-GAP with dual PH domain-containing protein 1	binding ion binding phosphatidylinositol-3,4,5-trisphosphate binding anion binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding phosphatidylinositol bisphosphate binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity binding ion binding phosphatidylinositol-3,4,5-trisphosphate binding anion binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding small molecule binding phosphatidylinositol bisphosphate binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity alcohol binding inositol 1,3,4,5 tetrakisphosphate binding cation binding metal ion binding	cellular response to stimulus regulation of biological process regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation cellular process signal transduction cell communication regulation of molecular function regulation of catalytic activity regulation of hydrolase activity regulation of GTPase activity	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane membrane-bounded organelle intracellular organelle organelle intracellular membrane-bounded organelle nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth X]	IPR001849	Pleckstrin homology domain	Domain
A [auth X]	IPR037849	ADAP, PH domain 1	Domain
A [auth X]	IPR037851	ADAP, PH domain 2	Domain
A [auth X]	IPR037278	ARFGAP/RecO-like zinc finger	Homologous Superfamily
A [auth X]	IPR011993	PH-like domain superfamily	Homologous Superfamily
A [auth X]	IPR052589	Arf-GAP with dual PH domain-containing protein	Family
A [auth X]	IPR001164	Arf GTPase activating protein	Domain
A [auth X]	IPR038508	ArfGAP domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth X]	Pharos: O75689	atrial fibrillation

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.