3MQM

Crystal Structure of the Bromodomain of human ASH1L

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3mqma1	All alpha proteins	Bromodomain-like	Bromodomain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
A	d3mqma2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3mqmb1	All alpha proteins	Bromodomain-like	Bromodomain	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3mqmb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Bromodomain	8084302	4000871	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Bromodomain	8084303	3001843	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Bromodomain	8084303	3001843	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Bromodomain	e3mqmA1	A: alpha bundles	X: Bromodomain-like	H: Bromodomain (From Topology)	T: Bromodomain	F: Bromodomain	ECOD (1.6)
B	Bromodomain	e3mqmB1	A: alpha bundles	X: Bromodomain-like	H: Bromodomain (From Topology)	T: Bromodomain	F: Bromodomain	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.20.920.10	Mainly Alpha	Up-down Bundle	Histone Acetyltransferase	Chain A	CATH (4.3.0)
B	1.20.920.10	Mainly Alpha	Up-down Bundle	Histone Acetyltransferase	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF00439	Bromodomain (Bromodomain)	Bromodomain	Bromodomains are 110 amino acid long domains, that are found in many chromatin associated proteins. Bromodomains can interact specifically with acetylated lysine [3].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Probable histone-lysine N-methyltransferase ASH1L	protein-lysine N-methyltransferase activity histone H3 methyltransferase activity catalytic activity, acting on a protein transferase activity, transferring one-carbon groups histone H3K9 methyltransferase activity transferase activity S-adenosylmethionine-dependent methyltransferase activity histone H3K9 monomethyltransferase activity histone methyltransferase activity lysine N-methyltransferase activity protein methyltransferase activity histone modifying activity N-methyltransferase activity methyltransferase activity catalytic activity protein-lysine N-methyltransferase activity histone H3 methyltransferase activity catalytic activity, acting on a protein transferase activity, transferring one-carbon groups histone H3K9 methyltransferase activity transferase activity S-adenosylmethionine-dependent methyltransferase activity histone H3K9 monomethyltransferase activity histone methyltransferase activity lysine N-methyltransferase activity protein methyltransferase activity histone modifying activity N-methyltransferase activity methyltransferase activity catalytic activity chromatin binding binding histone H3K9me2 methyltransferase activity DNA binding organic cyclic compound binding nucleic acid binding histone H3K4 methyltransferase activity histone H3K36 methyltransferase activity histone H3K36 trimethyltransferase activity cation binding ion binding metal ion binding small molecule binding	developmental process multicellular organism development multicellular organismal process skeletal system development anatomical structure development system development RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process developmental process multicellular organism development multicellular organismal process skeletal system development anatomical structure development system development RNA metabolic process primary metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process RNA biosynthetic process nucleobase-containing compound metabolic process DNA-templated transcription nucleic acid biosynthetic process transcription by RNA polymerase II biosynthetic process metabolic process cellular process macromolecule metabolic process methylation skin development gland development animal organ development tarsal gland development sebaceous gland development reproductive system development reproductive process uterus development developmental process involved in reproduction uterus morphogenesis anatomical structure morphogenesis reproductive structure development animal organ morphogenesis sexual reproduction fertilization single fertilization uterine gland development sperm motility cilium movement involved in cell motility cilium or flagellum-dependent cell motility cilium-dependent cell motility flagellated sperm motility microtubule-based movement microtubule-based process cilium movement cell motility cellular response to stimulus regulation of biological process regulation of cellular process response to stimulus signaling biological regulation intracellular signal transduction cell communication intracellular signaling cassette MAPK cascade signal transduction negative regulation of signaling negative regulation of intracellular signal transduction negative regulation of biological process regulation of signal transduction negative regulation of cell communication regulation of intracellular signal transduction negative regulation of cellular process regulation of signaling negative regulation of response to stimulus regulation of MAPK cascade negative regulation of signal transduction regulation of response to stimulus regulation of cell communication negative regulation of MAPK cascade regulation of primary metabolic process regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of biosynthetic process regulation of macromolecule metabolic process regulation of gene expression regulation of macromolecule biosynthetic process regulation of DNA-templated transcription regulation of metabolic process multi-multicellular organism process placenta development maternal process involved in female pregnancy multicellular organismal reproductive process tissue development maternal placenta development female pregnancy multi-organism reproductive process decidualization regulation of defense response negative regulation of acute inflammatory response regulation of response to external stimulus defense response negative regulation of inflammatory response response to external stimulus regulation of inflammatory response response to stress negative regulation of response to external stimulus regulation of response to stress negative regulation of defense response regulation of acute inflammatory response inflammatory response acute inflammatory response positive regulation of DNA-templated transcription positive regulation of biological process positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process positive regulation of macromolecule metabolic process positive regulation of cellular process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process post-embryonic development	membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen Golgi apparatus cytoplasm membrane-bounded organelle intracellular anatomical structure nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen intracellular organelle cellular anatomical structure nucleoplasm organelle lumen organelle nuclear lumen Golgi apparatus cytoplasm endomembrane system membraneless organelle intracellular membraneless organelle chromosome cell-cell junction apical junction complex bicellular tight junction tight junction anchoring junction cell junction

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR006560	AWS domain	Domain
A, B	IPR001965	Zinc finger, PHD-type	Domain
A, B	IPR046341	SET domain superfamily	Homologous Superfamily
A, B	IPR001214	SET domain	Domain
A, B	IPR001487	Bromodomain	Domain
A, B	IPR001025	Bromo adjacent homology (BAH) domain	Domain
A, B	IPR043319	ASH1-like, PHD finger	Domain
A, B	IPR043320	ASH1-like, Bromodomain	Domain
A, B	IPR011011	Zinc finger, FYVE/PHD-type	Homologous Superfamily
A, B	IPR003616	Post-SET domain	Domain
A, B	IPR019786	Zinc finger, PHD-type, conserved site	Conserved Site
A, B	IPR043151	Bromo adjacent homology (BAH) domain superfamily	Homologous Superfamily
A, B	IPR013083	Zinc finger, RING/FYVE/PHD-type	Homologous Superfamily
A, B	IPR036427	Bromodomain-like superfamily	Homologous Superfamily
A, B	IPR017956	AT hook, DNA-binding motif	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9NR48	Neurodevelopmental Disorders prostate cancer liver cancer pancreatic intraductal papillary-mucinous neoplasm acute myeloid leukemia Becker muscular dystrophy glioblastoma large cell medulloblastoma liver neoplasm pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Sjogren syndrome atypical teratoid rhabdoid tumor Crohn disease intellectual disability Neurodevelopmental Disorders prostate cancer liver cancer pancreatic intraductal papillary-mucinous neoplasm acute myeloid leukemia Becker muscular dystrophy glioblastoma large cell medulloblastoma liver neoplasm pancreatic ductal adenocarcinoma pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia Sjogren syndrome atypical teratoid rhabdoid tumor Crohn disease intellectual disability Lewy body dementia malignant glioma osteosarcoma pancreatic intraductal papillary-mucinous carcinoma spina bifida autism spectrum disorder gastric carcinoma intellectual disability, autosomal dominant 52 medulloblastoma ovarian cancer

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.