3MTC

Crystal Structure of INPP5B in complex with phosphatidylinositol 4-phosphate

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	DNase I-like	8067497	3000957	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Exo_endo_phos	e3mtcA1	A: a+b four layers	X: Carbon-nitrogen hydrolase-like	H: DNase I-like (From Topology)	T: DNase I-like	F: Exo_endo_phos	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.60.10.10	Alpha Beta	4-Layer Sandwich	Deoxyribonuclease I	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF22669	Endonuclease/Exonuclease/phosphatase family 2 (Exo_endo_phos2)	Endonuclease/Exonuclease/phosphatase family 2	This large family of proteins includes a number of nucleases and phosphatases such as DNAase I, Exonuclease III and Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase [1-5].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Type II inositol-1,4,5-trisphosphate 5-phosphatase	inositol trisphosphate phosphatase activity phosphoric ester hydrolase activity inositol-polyphosphate 5-phosphatase activity inositol phosphate phosphatase activity hydrolase activity, acting on ester bonds inositol-1,4,5-trisphosphate 5-phosphatase activity phosphatase activity hydrolase activity catalytic activity phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity phosphatidylinositol-4,5-bisphosphate phosphatase activity phosphatidylinositol bisphosphate phosphatase activity phosphatidylinositol phosphate 5-phosphatase activity phosphatidylinositol phosphate phosphatase activity inositol trisphosphate phosphatase activity phosphoric ester hydrolase activity inositol-polyphosphate 5-phosphatase activity inositol phosphate phosphatase activity hydrolase activity, acting on ester bonds inositol-1,4,5-trisphosphate 5-phosphatase activity phosphatase activity hydrolase activity catalytic activity phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity phosphatidylinositol-4,5-bisphosphate phosphatase activity phosphatidylinositol bisphosphate phosphatase activity phosphatidylinositol phosphate 5-phosphatase activity phosphatidylinositol phosphate phosphatase activity inositol tetrakisphosphate phosphatase activity inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity cation binding ion binding binding metal ion binding small molecule binding	developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation phosphatidylinositol metabolic process dephosphorylation cellular metabolic process glycerophospholipid metabolic process lipid modification primary metabolic process developmental process spermatogenesis sexual reproduction reproductive process multicellular organismal reproductive process developmental process involved in reproduction male gamete generation gamete generation phosphatidylinositol metabolic process dephosphorylation cellular metabolic process glycerophospholipid metabolic process lipid modification primary metabolic process phospholipid metabolic process organophosphate metabolic process phosphatidylinositol dephosphorylation phospholipid dephosphorylation phosphate-containing compound metabolic process cellular lipid metabolic process metabolic process cellular process glycerolipid metabolic process phosphorus metabolic process lipid metabolic process polyol metabolic process organic hydroxy compound metabolic process alcohol metabolic process inositol phosphate metabolic process small molecule metabolic process regulation of protein maturation regulation of cellular process cellular biosynthetic process regulation of primary metabolic process protein maturation regulation of proteolysis proteolysis protein metabolic process regulation of biosynthetic process regulation of biological process regulation of protein metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process regulation of protein processing protein processing regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process cellular response to stimulus response to stimulus signaling signal transduction cell communication sperm motility cilium movement involved in cell motility cilium or flagellum-dependent cell motility cilium-dependent cell motility flagellated sperm motility microtubule-based movement microtubule-based process cilium movement cell motility multicellular organism development multicellular organismal process embryo development ending in birth or egg hatching chordate embryonic development anatomical structure development embryo development in utero embryonic development	membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane-bounded organelle intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle intracellular organelle phagocytic vesicle membrane cytoplasmic vesicle membrane membrane cellular anatomical entity intracellular anatomical structure cytoplasm cytosol cell periphery plasma membrane membrane-bounded organelle intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle intracellular organelle phagocytic vesicle membrane cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane organelle endocytic vesicle membrane vesicle organelle membrane endocytic vesicle Golgi apparatus endomembrane system endosome membrane early endosome endosome early endosome membrane endoplasmic reticulum-Golgi intermediate compartment

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR031896	INPP5B, PH domain	Domain
A	IPR037793	OCRL1/INPP5B, INPP5c domain	Domain
A	IPR048869	OCRL-1/2, ASH domain	Domain
A	IPR008936	Rho GTPase activation protein	Homologous Superfamily
A	IPR000198	Rho GTPase-activating protein domain	Domain
A	IPR000300	Inositol polyphosphate-related phosphatase	Domain
A	IPR047078	Inositol polyphosphate 5-phosphatase OCRL, RhoGAP	Domain
A	IPR046985	Inositol 5-phosphatase	Family
A	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
A	IPR036691	Endonuclease/exonuclease/phosphatase superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P32019	colorectal adenoma heart disease Pick disease colorectal cancer lung cancer rheumatoid arthritis Hashimoto thyroiditis oculocerebrorenal syndrome

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.