3NRR
Co-crystal structure of dihydrofolate reductase-thymidylate synthase from Babesia bovis with dUMP, Raltitrexed and NADP
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d3nrra1 | Alpha and beta proteins (a/b) | Dihydrofolate reductase-like | Dihydrofolate reductase-like | automated matches | automated matches | (Babesia bovis ) [TaxId: 5865 ], | SCOPe (2.08) |
A | d3nrra2 | Alpha and beta proteins (a+b) | Thymidylate synthase/dCMP hydroxymethylase | Thymidylate synthase/dCMP hydroxymethylase | automated matches | automated matches | (Babesia bovis ) [TaxId: 5865 ], | SCOPe (2.08) |
B | d3nrrb1 | Alpha and beta proteins (a/b) | Dihydrofolate reductase-like | Dihydrofolate reductase-like | automated matches | automated matches | (Babesia bovis ) [TaxId: 5865 ], | SCOPe (2.08) |
B | d3nrrb2 | Alpha and beta proteins (a+b) | Thymidylate synthase/dCMP hydroxymethylase | Thymidylate synthase/dCMP hydroxymethylase | automated matches | automated matches | (Babesia bovis ) [TaxId: 5865 ], | SCOPe (2.08) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | Thymidylat_synt | e3nrrA2 | A: a+b two layers | X: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | H: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | T: Thymidylate synthase/dCMP hydroxymethylase | F: Thymidylat_synt | ECOD (1.6) |
A | DHFR_1 | e3nrrA1 | A: a/b three-layered sandwiches | X: Dihydrofolate reductases (From Topology) | H: Dihydrofolate reductases (From Topology) | T: Dihydrofolate reductases | F: DHFR_1 | ECOD (1.6) |
B | Thymidylat_synt | e3nrrB3 | A: a+b two layers | X: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | H: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | T: Thymidylate synthase/dCMP hydroxymethylase | F: Thymidylat_synt | ECOD (1.6) |
B | DHFR_1 | e3nrrB2 | A: a/b three-layered sandwiches | X: Dihydrofolate reductases (From Topology) | H: Dihydrofolate reductases (From Topology) | T: Dihydrofolate reductases | F: DHFR_1 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.40.430.10 | Alpha Beta | 3-Layer(aba) Sandwich | Dihydrofolate Reductase, subunit A | Dihydrofolate Reductase, subunit A | CATH (4.3.0) |
A | 3.30.572.10 | Alpha Beta | 2-Layer Sandwich | Thymidylate Synthase | Chain A | CATH (4.3.0) |
B | 3.40.430.10 | Alpha Beta | 3-Layer(aba) Sandwich | Dihydrofolate Reductase, subunit A | Dihydrofolate Reductase, subunit A | CATH (4.3.0) |
B | 3.30.572.10 | Alpha Beta | 2-Layer Sandwich | Thymidylate Synthase | Chain A | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00303 | Thymidylate synthase (Thymidylat_synt) | Thymidylate synthase | This is a family of proteins that are flavin-dependent thymidylate synthases. | Domain | |
PF00186 | Dihydrofolate reductase (DHFR_1) | Dihydrofolate reductase | - | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR036926 | Thymidylate synthase/dCMP hydroxymethylase superfamily | Homologous Superfamily | |
IPR012262 | Bifunctional dihydrofolate reductase/thymidylate synthase | Family | |
IPR000398 | Thymidylate synthase | Family | |
IPR024072 | Dihydrofolate reductase-like domain superfamily | Homologous Superfamily | |
IPR001796 | Dihydrofolate reductase domain | Domain | |
IPR045097 | Thymidylate synthase/dCMP hydroxymethylase | Family | |
IPR020940 | Thymidylate synthase, active site | Active Site | |
IPR023451 | Thymidylate synthase/dCMP hydroxymethylase domain | Domain |