3P0F

Structure of hUPP2 in an inactive conformation with bound 5-benzylacyclouridine

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3p0fa_	Alpha and beta proteins (a/b)	Phosphorylase/hydrolase-like	Purine and uridine phosphorylases	automated matches	automated matches	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	PNP_UDP_1	e3p0fA1	A: a/b three-layered sandwiches	X: Phosphorylase/hydrolase-like	H: Peptidyl-tRNA hydrolase-like (From Topology)	T: Peptidyl-tRNA hydrolase-like	F: PNP_UDP_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.1580	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	Nucleoside phosphorylase domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF01048	Phosphorylase superfamily (PNP_UDP_1)	Phosphorylase superfamily	Members of this family include: purine nucleoside phosphorylase (PNP) Uridine phosphorylase (UdRPase) 5'-methylthioadenosine phosphorylase (MTA phosphorylase)	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Uridine phosphorylase 2	deoxyuridine phosphorylase activity pentosyltransferase activity glycosyltransferase activity transferase activity catalytic activity pyrimidine-nucleoside phosphorylase activity uridine phosphorylase activity identical protein binding protein binding binding	glycosyl compound metabolic process pyrimidine-containing compound metabolic process uridine metabolic process carbohydrate derivative metabolic process primary metabolic process pyrimidine nucleoside metabolic process nucleoside metabolic process nucleobase-containing compound metabolic process pyrimidine ribonucleoside metabolic process nucleobase-containing small molecule metabolic process small molecule metabolic process metabolic process ribonucleoside metabolic process pyrimidine deoxyribonucleotide catabolic process glycosyl compound metabolic process pyrimidine-containing compound metabolic process uridine metabolic process carbohydrate derivative metabolic process primary metabolic process pyrimidine nucleoside metabolic process nucleoside metabolic process nucleobase-containing compound metabolic process pyrimidine ribonucleoside metabolic process nucleobase-containing small molecule metabolic process small molecule metabolic process metabolic process ribonucleoside metabolic process pyrimidine deoxyribonucleotide catabolic process pyrimidine deoxyribonucleoside monophosphate catabolic process catabolic process deoxyribonucleoside monophosphate catabolic process deoxyribonucleotide catabolic process pyrimidine deoxyribonucleotide metabolic process pyrimidine-containing compound catabolic process organophosphate catabolic process dCMP catabolic process nucleoside phosphate catabolic process deoxyribose phosphate catabolic process pyrimidine nucleotide metabolic process pyrimidine deoxyribonucleoside monophosphate metabolic process pyrimidine nucleotide catabolic process deoxyribonucleotide metabolic process phosphate-containing compound metabolic process nucleoside monophosphate metabolic process phosphorus metabolic process nucleotide catabolic process pyrimidine nucleoside monophosphate catabolic process dCMP metabolic process nucleoside phosphate metabolic process pyrimidine nucleoside monophosphate metabolic process carbohydrate derivative catabolic process nucleoside monophosphate catabolic process cellular metabolic process 2'-deoxyribonucleotide metabolic process nucleotide metabolic process deoxyribose phosphate metabolic process deoxyribonucleoside monophosphate metabolic process nucleobase-containing compound catabolic process organophosphate metabolic process cellular process pyrimidine nucleoside catabolic process glycosyl compound catabolic process uridine catabolic process nucleobase-containing small molecule catabolic process nucleoside catabolic process pyrimidine ribonucleoside catabolic process small molecule catabolic process ribonucleoside catabolic process ribose phosphate metabolic process nucleotide biosynthetic process pyrimidine ribonucleotide salvage pyrimidine-containing compound salvage pyrimidine nucleotide salvage nucleotide salvage ribonucleotide biosynthetic process UMP salvage UMP biosynthetic process ribonucleotide metabolic process ribonucleoside monophosphate metabolic process UMP metabolic process pyrimidine-containing compound biosynthetic process ribose phosphate biosynthetic process cellular metabolic compound salvage pyrimidine ribonucleotide metabolic process carbohydrate derivative biosynthetic process pyrimidine ribonucleoside monophosphate metabolic process nucleobase-containing compound biosynthetic process nucleoside monophosphate biosynthetic process biosynthetic process pyrimidine ribonucleoside monophosphate biosynthetic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process pyrimidine nucleoside monophosphate biosynthetic process ribonucleoside monophosphate biosynthetic process pyrimidine nucleotide biosynthetic process pyrimidine ribonucleotide biosynthetic process	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol polymeric cytoskeletal fiber type III intermediate filament intermediate filament cytoskeleton intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle intermediate filament supramolecular fiber supramolecular polymer intracellular anatomical structure cytoplasm cellular anatomical entity cytosol polymeric cytoskeletal fiber type III intermediate filament intermediate filament cytoskeleton intracellular organelle cytoskeleton organelle intracellular non-membrane-bounded organelle intermediate filament supramolecular fiber supramolecular polymer supramolecular complex non-membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR035994	Nucleoside phosphorylase superfamily	Homologous Superfamily
A	IPR010059	Uridine phosphorylase, eukaryotic	Family
A	IPR018016	Nucleoside phosphorylase, conserved site	Conserved Site
A	IPR000845	Nucleoside phosphorylase domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: O95045	atypical teratoid rhabdoid tumor glioblastoma malignant glioma pancreatic ductal adenocarcinoma autism spectrum disorder large cell medulloblastoma medulloblastoma primitive neuroectodermal tumor Autism Spectrum Disorders malignant ependymoma oligodendroglioma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.