3PSR

HUMAN PSORIASIN (S100A7) CA2+ BOUND FORM (CRYSTAL FORM I)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3psra_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3psrb_	All alpha proteins	EF Hand-like	EF-hand	S100 proteins	Calcyclin (S100)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	EF-hand	8037289	3001983	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	EF-hand	8037289	3001983	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	S_100	e3psrA1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)
B	S_100	e3psrB1	A: alpha arrays	X: EF-hand	H: EF-hand-related	T: EF-hand	F: S_100	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)
B	1.10.238.10	Mainly Alpha	Orthogonal Bundle	Recoverin	domain 1	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01023	S-100/ICaBP type calcium binding domain (S_100)	S-100/ICaBP type calcium binding domain	The S-100 domain is a subfamily of the EF-hand calcium binding proteins.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	PSORIASIN	cation binding ion binding binding calcium ion binding metal ion binding small molecule binding molecular sequestering activity metal ion sequestering activity zinc ion sequestering activity RAGE receptor binding protein binding signaling receptor binding calcium-dependent protein binding transition metal ion binding cation binding ion binding binding calcium ion binding metal ion binding small molecule binding molecular sequestering activity metal ion sequestering activity zinc ion sequestering activity RAGE receptor binding protein binding signaling receptor binding calcium-dependent protein binding transition metal ion binding zinc ion binding	developmental process epithelium development epidermal cell differentiation cellular developmental process epidermis development animal organ development tissue development epithelial cell differentiation skin development cell differentiation keratinocyte differentiation anatomical structure development cellular process cellular response to stimulus developmental process epithelium development epidermal cell differentiation cellular developmental process epidermis development animal organ development tissue development epithelial cell differentiation skin development cell differentiation keratinocyte differentiation anatomical structure development cellular process cellular response to stimulus positive regulation of cell communication regulation of cellular process positive regulation of signal transduction response to stimulus signaling positive regulation of biological process regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus positive regulation of ERK1 and ERK2 cascade regulation of intracellular signal transduction intracellular signaling cassette signal transduction positive regulation of cellular process regulation of biological process regulation of signaling positive regulation of MAPK cascade biological regulation positive regulation of intracellular signal transduction regulation of MAPK cascade regulation of response to stimulus MAPK cascade regulation of cell communication ERK1 and ERK2 cascade regulation of ERK1 and ERK2 cascade positive regulation of signaling multicellular organismal process blood vessel morphogenesis tube development angiogenesis vasculature development circulatory system development multicellular organism development anatomical structure morphogenesis tube morphogenesis anatomical structure formation involved in morphogenesis blood vessel development system development positive regulation of monocyte chemotaxis positive regulation of locomotion regulation of cell motility regulation of response to external stimulus positive regulation of chemotaxis positive regulation of cell migration regulation of monocyte chemotaxis positive regulation of response to external stimulus taxis positive regulation of cell motility regulation of cell migration myeloid leukocyte migration positive regulation of mononuclear cell migration cell migration regulation of immune system process cell motility regulation of mononuclear cell migration positive regulation of immune system process locomotion cell chemotaxis chemotaxis regulation of leukocyte chemotaxis regulation of leukocyte migration response to external stimulus positive regulation of leukocyte migration positive regulation of leukocyte chemotaxis regulation of chemotaxis monocyte chemotaxis leukocyte migration cellular response to chemical stimulus immune system process response to chemical regulation of locomotion mononuclear cell migration leukocyte chemotaxis humoral immune response biological process involved in interspecies interaction between organisms response to other organism defense response immune response defense response to symbiont antimicrobial humoral response response to biotic stimulus antimicrobial humoral immune response mediated by antimicrobial peptide defense response to other organism response to stress response to external biotic stimulus positive regulation of T cell chemotaxis regulation of lymphocyte chemotaxis positive regulation of lymphocyte migration lymphocyte migration regulation of T cell migration regulation of T cell chemotaxis lymphocyte chemotaxis regulation of lymphocyte migration positive regulation of lymphocyte chemotaxis T cell chemotaxis positive regulation of T cell migration T cell migration response to oxidative stress response to oxygen-containing compound response to reactive oxygen species response to lipid response to lipopolysaccharide response to bacterium response to molecule of bacterial origin regulation of granulocyte chemotaxis granulocyte migration positive regulation of granulocyte chemotaxis granulocyte chemotaxis	cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle lytic vacuole cellular anatomical structure anchoring junction cell junction focal adhesion cell-substrate junction cell periphery extracellular matrix external encapsulating structure collagen-containing extracellular matrix intracellular anatomical structure cytoplasm cytosol membrane-bounded organelle lytic vacuole intracellular vesicle membrane-enclosed lumen cytoplasmic vesicle lumen vacuolar lumen endomembrane system intracellular organelle lumen intracellular organelle cytoplasmic vesicle vesicle lysosome vesicle lumen azurophil granule vacuole intracellular membrane-bounded organelle secretory granule lumen azurophil granule lumen organelle lumen organelle secretory granule primary lysosome secretory vesicle extracellular region extracellular space nucleus endoplasmic reticulum

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR034325	S-100	Domain
A, B	IPR001751	S100/Calcium binding protein 7/8-like, conserved site	Conserved Site
A, B	IPR002048	EF-hand domain	Domain
A, B	IPR011992	EF-hand domain pair	Homologous Superfamily
A, B	IPR018247	EF-Hand 1, calcium-binding site	Binding Site
A, B	IPR013787	S100/CaBP-9k-type, calcium binding, subdomain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: P31151	psoriasis Pustulosis of Palms and Soles pustulosis palmaris et plantaris

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.