3PWQ

The Phenylacetyl-CoA monooxygenase PaaAC subcomplex

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
C [auth B]	d3pwqb1	All alpha proteins	Ferritin-like	Ferritin-like	Ribonucleotide reductase-like	automated matches	(Escherichia coli str. K-12 substr. MG1655 ) [TaxId: 511145 ],	SCOPe (2.08)
C [auth B]	d3pwqb2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Escherichia coli str. K-12 substr. MG1655 ) [TaxId: 511145 ],	SCOPe (2.08)
A	d3pwqa1	All alpha proteins	Ferritin-like	Ferritin-like	Ribonucleotide reductase-like	automated matches	(Escherichia coli str. K-12 substr. MG1655 ) [TaxId: 511145 ],	SCOPe (2.08)
A	d3pwqa2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Escherichia coli str. K-12 substr. MG1655 ) [TaxId: 511145 ],	SCOPe (2.08)
E	d3pwqe1	All alpha proteins	Ferritin-like	Ferritin-like	Ribonucleotide reductase-like	automated matches	(Escherichia coli str. K-12 substr. MG1655 ) [TaxId: 511145 ],	SCOPe (2.08)
E	d3pwqe2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Escherichia coli str. K-12 substr. MG1655 ) [TaxId: 511145 ],	SCOPe (2.08)
G	d3pwqg1	All alpha proteins	Ferritin-like	Ferritin-like	Ribonucleotide reductase-like	automated matches	(Escherichia coli str. K-12 substr. MG1655 ) [TaxId: 511145 ],	SCOPe (2.08)
G	d3pwqg2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Escherichia coli str. K-12 substr. MG1655 ) [TaxId: 511145 ],	SCOPe (2.08)
I	d3pwqi1	All alpha proteins	Ferritin-like	Ferritin-like	Ribonucleotide reductase-like	automated matches	(Escherichia coli str. K-12 substr. MG1655 ) [TaxId: 511145 ],	SCOPe (2.08)
I	d3pwqi2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Escherichia coli str. K-12 substr. MG1655 ) [TaxId: 511145 ],	SCOPe (2.08)
J	d3pwqj1	All alpha proteins	Ferritin-like	Ferritin-like	Ribonucleotide reductase-like	automated matches	(Escherichia coli str. K-12 substr. MG1655 ) [TaxId: 511145 ],	SCOPe (2.08)
J	d3pwqj2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Escherichia coli str. K-12 substr. MG1655 ) [TaxId: 511145 ],	SCOPe (2.08)
K	d3pwqk_	All alpha proteins	Ferritin-like	Ferritin-like	Ribonucleotide reductase-like	automated matches	(Escherichia coli str. K-12 substr. MG1655 ) [TaxId: 511145 ],	SCOPe (2.08)
L [auth R]	d3pwqr1	All alpha proteins	Ferritin-like	Ferritin-like	Ribonucleotide reductase-like	automated matches	(Escherichia coli str. K-12 substr. MG1655 ) [TaxId: 511145 ],	SCOPe (2.08)
L [auth R]	d3pwqr2	Artifacts	Tags	Tags	Tags	N-terminal Tags	(Escherichia coli str. K-12 substr. MG1655 ) [TaxId: 511145 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
C [auth B]	SCOP2B Superfamily	Ferritin-like	8037775	3001658	SCOP2B (2022-06-29)
A	SCOP2B Superfamily	Ferritin-like	8037775	3001658	SCOP2B (2022-06-29)
E	SCOP2B Superfamily	Ferritin-like	8037775	3001658	SCOP2B (2022-06-29)
G	SCOP2B Superfamily	Ferritin-like	8037775	3001658	SCOP2B (2022-06-29)
I	SCOP2B Superfamily	Ferritin-like	8037775	3001658	SCOP2B (2022-06-29)
J	SCOP2B Superfamily	Ferritin-like	8037775	3001658	SCOP2B (2022-06-29)
K	SCOP2B Superfamily	Ferritin-like	8037775	3001658	SCOP2B (2022-06-29)
L [auth R]	SCOP2B Superfamily	Ferritin-like	8037775	3001658	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
C [auth B]	PaaA_PaaC	e3pwqB1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Heme oxygenase/Ribonucleotide reductase	F: PaaA_PaaC	ECOD (1.6)
A	PaaA_PaaC	e3pwqA1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Heme oxygenase/Ribonucleotide reductase	F: PaaA_PaaC	ECOD (1.6)
E	PaaA_PaaC	e3pwqE1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Heme oxygenase/Ribonucleotide reductase	F: PaaA_PaaC	ECOD (1.6)
G	PaaA_PaaC	e3pwqG1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Heme oxygenase/Ribonucleotide reductase	F: PaaA_PaaC	ECOD (1.6)
I	PaaA_PaaC	e3pwqI1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Heme oxygenase/Ribonucleotide reductase	F: PaaA_PaaC	ECOD (1.6)
J	PaaA_PaaC	e3pwqJ1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Heme oxygenase/Ribonucleotide reductase	F: PaaA_PaaC	ECOD (1.6)
K	PaaA_PaaC	e3pwqK1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Heme oxygenase/Ribonucleotide reductase	F: PaaA_PaaC	ECOD (1.6)
L [auth R]	PaaA_PaaC	e3pwqR1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Heme oxygenase/Ribonucleotide reductase	F: PaaA_PaaC	ECOD (1.6)
B [auth C]	PaaA_PaaC	e3pwqC1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Heme oxygenase/Ribonucleotide reductase	F: PaaA_PaaC	ECOD (1.6)
D	PaaA_PaaC	e3pwqD1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Heme oxygenase/Ribonucleotide reductase	F: PaaA_PaaC	ECOD (1.6)
F	PaaA_PaaC	e3pwqF1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Heme oxygenase/Ribonucleotide reductase	F: PaaA_PaaC	ECOD (1.6)
H	PaaA_PaaC	e3pwqH1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: Ferritin/Heme oxygenase	T: Heme oxygenase/Ribonucleotide reductase	F: PaaA_PaaC	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
C [auth B]	1.20.1260.10	Mainly Alpha	Up-down Bundle	Ferritin	Ferritin, core subunit, four-helix bundle	CATH (4.3.0)
A	1.20.1260.10	Mainly Alpha	Up-down Bundle	Ferritin	Ferritin, core subunit, four-helix bundle	CATH (4.3.0)
E	1.20.1260.10	Mainly Alpha	Up-down Bundle	Ferritin	Ferritin, core subunit, four-helix bundle	CATH (4.3.0)
G	1.20.1260.10	Mainly Alpha	Up-down Bundle	Ferritin	Ferritin, core subunit, four-helix bundle	CATH (4.3.0)
I	1.20.1260.10	Mainly Alpha	Up-down Bundle	Ferritin	Ferritin, core subunit, four-helix bundle	CATH (4.3.0)
J	1.20.1260.10	Mainly Alpha	Up-down Bundle	Ferritin	Ferritin, core subunit, four-helix bundle	CATH (4.3.0)
K	1.20.1260.10	Mainly Alpha	Up-down Bundle	Ferritin	Ferritin, core subunit, four-helix bundle	CATH (4.3.0)
L [auth R]	1.20.1260.10	Mainly Alpha	Up-down Bundle	Ferritin	Ferritin, core subunit, four-helix bundle	CATH (4.3.0)
B [auth C]	1.20.1260.10	Mainly Alpha	Up-down Bundle	Ferritin	Ferritin, core subunit, four-helix bundle	CATH (4.3.0)
D	1.20.1260.10	Mainly Alpha	Up-down Bundle	Ferritin	Ferritin, core subunit, four-helix bundle	CATH (4.3.0)
F	1.20.1260.10	Mainly Alpha	Up-down Bundle	Ferritin	Ferritin, core subunit, four-helix bundle	CATH (4.3.0)
H	1.20.1260.10	Mainly Alpha	Up-down Bundle	Ferritin	Ferritin, core subunit, four-helix bundle	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C [auth B], E, G, I, A, C [auth B], E, G, I, J, K, L [auth R]	PF05138	Phenylacetic acid catabolic protein (PaaA_PaaC)	Phenylacetic acid catabolic protein	This family includes proteins such as PaaA and PaaC that are part of a catabolic pathway of phenylacetic acid [1]. These proteins may form part of a dioxygenase complex.	Domain
B [auth C], D, F, H	PF05138	Phenylacetic acid catabolic protein (PaaA_PaaC)	Phenylacetic acid catabolic protein	This family includes proteins such as PaaA and PaaC that are part of a catabolic pathway of phenylacetic acid [1]. These proteins may form part of a dioxygenase complex.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, C [auth B], E, G, I, A, C [auth B], E, G, I, J, K, L [auth R]	Phenylacetic acid degradation protein paaC	-	cellular response to stimulus catabolic process response to stimulus oxoacid metabolic process organic acid catabolic process organic acid metabolic process response to xenobiotic stimulus cellular catabolic process monocarboxylic acid catabolic process carboxylic acid catabolic process small molecule metabolic process benzene-containing compound metabolic process cellular response to xenobiotic stimulus carboxylic acid metabolic process cellular response to stimulus catabolic process response to stimulus oxoacid metabolic process organic acid catabolic process organic acid metabolic process response to xenobiotic stimulus cellular catabolic process monocarboxylic acid catabolic process carboxylic acid catabolic process small molecule metabolic process benzene-containing compound metabolic process cellular response to xenobiotic stimulus carboxylic acid metabolic process xenobiotic catabolic process xenobiotic metabolic process cellular response to chemical stimulus response to chemical phenylacetate catabolic process metabolic process cellular process monocarboxylic acid metabolic process small molecule catabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol phenylacetyl-CoA 1,2-epoxidase complex protein-containing complex catalytic complex oxidoreductase complex
B [auth C], D, F, H	Phenylacetic acid degradation protein paaA	oxidoreductase activity monooxygenase activity oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen phenylacetyl-CoA 1,2-epoxidase activity catalytic activity	cellular response to stimulus catabolic process response to stimulus oxoacid metabolic process organic acid catabolic process organic acid metabolic process response to xenobiotic stimulus cellular catabolic process monocarboxylic acid catabolic process carboxylic acid catabolic process small molecule metabolic process benzene-containing compound metabolic process cellular response to xenobiotic stimulus carboxylic acid metabolic process cellular response to stimulus catabolic process response to stimulus oxoacid metabolic process organic acid catabolic process organic acid metabolic process response to xenobiotic stimulus cellular catabolic process monocarboxylic acid catabolic process carboxylic acid catabolic process small molecule metabolic process benzene-containing compound metabolic process cellular response to xenobiotic stimulus carboxylic acid metabolic process xenobiotic catabolic process xenobiotic metabolic process cellular response to chemical stimulus response to chemical phenylacetate catabolic process metabolic process cellular process monocarboxylic acid metabolic process small molecule catabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol phenylacetyl-CoA 1,2-epoxidase complex protein-containing complex catalytic complex oxidoreductase complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C [auth B], E, G, I, A, C [auth B], E, G, I, J, K, L [auth R]	IPR052703	Aromatic CoA oxygenase/epoxidase components	Family
A, C [auth B], E, G, I, A, C [auth B], E, G, I, J, K, L [auth R]	IPR012347	Ferritin-like	Homologous Superfamily
A, C [auth B], E, G, I, A, C [auth B], E, G, I, J, K, L [auth R]	IPR009078	Ferritin-like superfamily	Homologous Superfamily
A, C [auth B], E, G, I, A, C [auth B], E, G, I, J, K, L [auth R]	IPR007814	1,2-phenylacetyl-CoA epoxidase, subunit A/C	Family
A, C [auth B], E, G, I, A, C [auth B], E, G, I, J, K, L [auth R]	IPR011882	1,2-phenylacetyl-CoA epoxidase, subunit C	Family
B [auth C], D, F, H	IPR052703	Aromatic CoA oxygenase/epoxidase components	Family
B [auth C], D, F, H	IPR012347	Ferritin-like	Homologous Superfamily
B [auth C], D, F, H	IPR009078	Ferritin-like superfamily	Homologous Superfamily
B [auth C], D, F, H	IPR007814	1,2-phenylacetyl-CoA epoxidase, subunit A/C	Family
B [auth C], D, F, H	IPR011881	1,2-phenylacetyl-CoA epoxidase, subunit A	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.