Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad3qioa1 Alpha and beta proteins (a/b) Ribonuclease H-like motif Ribonuclease H-like Ribonuclease H HIV RNase H (Domain of reverse transcriptase) HIV-1 (HIV-1 M:B_HXB2R ) [TaxId: 11706 ], (Escherichia coli K-12 ) [TaxId: 83333 ], HIV-1 (HIV-1 M:B_HXB2R ) [TaxId: 11706 ], SCOPe (2.08)
Ad3qioa2 Artifacts Tags Tags Tags N-terminal Tags HIV-1 (HIV-1 M:B_HXB2R ) [TaxId: 11706 ], (Escherichia coli K-12 ) [TaxId: 83333 ], HIV-1 (HIV-1 M:B_HXB2R ) [TaxId: 11706 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyRibonuclease H-like 8044518 3000143 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ARNase_He3qioA1 A: mixed a+b and a/bX: Ribonuclease H-likeH: Ribonuclease H-like (From Topology)T: Ribonuclease H-likeF: RNase_HECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.30.420.10 Alpha Beta 2-Layer Sandwich Nucleotidyltransferase domain 5CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00075RNase H (RNase_H)RNase HRNase H digests the RNA strand of an RNA/DNA hybrid. Important enzyme in retroviral replication cycle, and often found as a domain associated with reverse transcriptases. Structure is a mixed alpha+beta fold with three a/b/a layers.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
Gag-Pol polyprotein,Ribonuclease HI,Gag-Pol polyprotein

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR036397Ribonuclease H superfamilyHomologous Superfamily
IPR022892Ribonuclease HIFamily
IPR002156Ribonuclease H domainDomain
IPR050092Ribonuclease HFamily
IPR012337Ribonuclease H-like superfamilyHomologous Superfamily
IPR036397Ribonuclease H superfamilyHomologous Superfamily
IPR043128Reverse transcriptase/Diguanylate cyclase domainHomologous Superfamily
IPR001995Peptidase A2A, retrovirus, catalyticDomain
IPR001878Zinc finger, CCHC-typeDomain
IPR008919Retrovirus capsid, N-terminalHomologous Superfamily
IPR012344Matrix protein, lentiviral and alpha-retroviral, N-terminalHomologous Superfamily
IPR036862Integrase, C-terminal domain superfamily, retroviralHomologous Superfamily
IPR018061RetropepsinsDomain
IPR010661Reverse transcriptase thumbDomain
IPR002156Ribonuclease H domainDomain
IPR036875Zinc finger, CCHC-type superfamilyHomologous Superfamily
IPR003308Integrase, N-terminal zinc-binding domainDomain
IPR001584Integrase, catalytic coreDomain
IPR045345Retroviral nucleocapsid Gag protein p24, C-terminal domainDomain
IPR010999Retroviral matrix proteinHomologous Superfamily
IPR021109Aspartic peptidase domain superfamilyHomologous Superfamily
IPR001969Aspartic peptidase, active siteActive Site
IPR012337Ribonuclease H-like superfamilyHomologous Superfamily
IPR017856Integrase-like, N-terminalHomologous Superfamily
IPR000071Immunodeficiency lentiviral matrix, N-terminalDomain
IPR043502DNA/RNA polymerase superfamilyHomologous Superfamily
IPR001037Integrase, C-terminal, retroviralDomain
IPR034170Retropepsin-like catalytic domainDomain
IPR000477Reverse transcriptase domainDomain
IPR010659Reverse transcriptase connectionDomain
IPR008916Retrovirus capsid, C-terminalHomologous Superfamily