Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad3tlha_ All beta proteins Acid proteases Acid proteases Retroviral protease (retropepsin) Human immunodeficiency virus type 1 protease (Human immunodeficiency virus type 1 (CLONE 12) ) [TaxId: 11679 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyAcid proteases 8072209 3001059 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
ARVPe3tlhA1 A: beta barrelsX: cradle loop barrelH: RIFT-relatedT: acid proteaseF: RVPECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A2.40.70.10 Mainly Beta Beta Barrel Cathepsin D, subunit A domain 1CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF00077Retroviral aspartyl protease (RVP)Retroviral aspartyl proteaseSingle domain aspartyl proteases from retroviruses, retrotransposons, and badnaviruses (plant dsDNA viruses). These proteases are generally part of a larger polyprotein; usually pol, more rarely gag. Retroviral proteases appear to be homologous to a ...Single domain aspartyl proteases from retroviruses, retrotransposons, and badnaviruses (plant dsDNA viruses). These proteases are generally part of a larger polyprotein; usually pol, more rarely gag. Retroviral proteases appear to be homologous to a single domain of the two-domain eukaryotic aspartyl proteases such as pepsins, cathepsins, and renins (Pfam:PF00026).
Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
PROTEIN (PROTEASE)

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
IPR036397Ribonuclease H superfamilyHomologous Superfamily
IPR043128Reverse transcriptase/Diguanylate cyclase domainHomologous Superfamily
IPR001995Peptidase A2A, retrovirus, catalyticDomain
IPR001878Zinc finger, CCHC-typeDomain
IPR008919Retrovirus capsid, N-terminalHomologous Superfamily
IPR012344Matrix protein, lentiviral and alpha-retroviral, N-terminalHomologous Superfamily
IPR036862Integrase, C-terminal domain superfamily, retroviralHomologous Superfamily
IPR018061RetropepsinsDomain
IPR010661Reverse transcriptase thumbDomain
IPR002156Ribonuclease H domainDomain
IPR036875Zinc finger, CCHC-type superfamilyHomologous Superfamily
IPR003308Integrase, N-terminal zinc-binding domainDomain
IPR001584Integrase, catalytic coreDomain
IPR045345Retroviral nucleocapsid Gag protein p24, C-terminal domainDomain
IPR010999Retroviral matrix proteinHomologous Superfamily
IPR021109Aspartic peptidase domain superfamilyHomologous Superfamily
IPR001969Aspartic peptidase, active siteActive Site
IPR012337Ribonuclease H-like superfamilyHomologous Superfamily
IPR017856Integrase-like, N-terminalHomologous Superfamily
IPR000071Immunodeficiency lentiviral matrix, N-terminalDomain
IPR043502DNA/RNA polymerase superfamilyHomologous Superfamily
IPR001037Integrase, C-terminal, retroviralDomain
IPR034170Retropepsin-like catalytic domainDomain
IPR000477Reverse transcriptase domainDomain
IPR010659Reverse transcriptase connectionDomain
IPR008916Retrovirus capsid, C-terminalHomologous Superfamily