3UCB
Crystal Structure of Multidrug Resistant HIV-1 Protease Clinical Isolate PR20 in Complex with Darunavir
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d3ucba_ | All beta proteins | Acid proteases | Acid proteases | Retroviral protease (retropepsin) | Human immunodeficiency virus type 1 protease | HIV-1 (Human immunodeficiency virus 1 ) [TaxId: 11676 ], | SCOPe (2.08) |
B | d3ucbb_ | All beta proteins | Acid proteases | Acid proteases | Retroviral protease (retropepsin) | Human immunodeficiency virus type 1 protease | HIV-1 (Human immunodeficiency virus 1 ) [TaxId: 11676 ], | SCOPe (2.08) |
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | RVP | e3ucbA1 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: acid protease | F: RVP | ECOD (1.6) |
B | RVP | e3ucbB1 | A: beta barrels | X: cradle loop barrel | H: RIFT-related | T: acid protease | F: RVP | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 2.40.70.10 | Mainly Beta | Beta Barrel | Cathepsin D, subunit A | domain 1 | CATH (4.3.0) |
B | 2.40.70.10 | Mainly Beta | Beta Barrel | Cathepsin D, subunit A | domain 1 | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00077 | Retroviral aspartyl protease (RVP) | Retroviral aspartyl protease | Single domain aspartyl proteases from retroviruses, retrotransposons, and badnaviruses (plant dsDNA viruses). These proteases are generally part of a larger polyprotein; usually pol, more rarely gag. Retroviral proteases appear to be homologous to a ... | Domain |