3VKK

Crystal Structure Of The Covalent Intermediate Of Human Cytosolic Beta-Glucosidase-mannose complex

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	(Trans)glycosidases	8065790	3000313	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Glyco_hydro_1	e3vkkA1	A: a/b barrels	X: TIM beta/alpha-barrel	H: TIM barrels (From Topology)	T: TIM barrels	F: Glyco_hydro_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.20.20.80	Alpha Beta	Alpha-Beta Barrel	TIM Barrel	Glycosidases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00232	Glycosyl hydrolase family 1 (Glyco_hydro_1)	Glycosyl hydrolase family 1	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Cytosolic beta-glucosidase	hydrolase activity, acting on glycosyl bonds glycosylceramidase activity hydrolase activity, hydrolyzing O-glycosyl compounds hydrolase activity galactosylceramidase activity catalytic activity glucosidase activity beta-glucosidase activity glucosylceramidase activity beta-galactosidase activity galactosidase activity	regulation of protein stability biological regulation regulation of biological quality protein stabilization glycoside catabolic process carbohydrate derivative catabolic process glycosyl compound metabolic process catabolic process glycoside metabolic process carbohydrate derivative metabolic process metabolic process cellular process glycosyl compound catabolic process membrane lipid metabolic process regulation of protein stability biological regulation regulation of biological quality protein stabilization glycoside catabolic process carbohydrate derivative catabolic process glycosyl compound metabolic process catabolic process glycoside metabolic process carbohydrate derivative metabolic process metabolic process cellular process glycosyl compound catabolic process membrane lipid metabolic process sphingolipid catabolic process glycosphingolipid catabolic process lipid catabolic process glycolipid metabolic process glycosphingolipid metabolic process liposaccharide metabolic process primary metabolic process sphingolipid metabolic process membrane lipid catabolic process glycolipid catabolic process lipid metabolic process carbohydrate metabolic process oligosaccharide catabolic process oligosaccharide metabolic process carbohydrate catabolic process beta-glucoside catabolic process beta-glucoside metabolic process positive regulation of molecular function regulation of molecular function positive regulation of hydrolase activity regulation of catalytic activity regulation of hydrolase activity regulation of exo-alpha-sialidase activity positive regulation of exo-alpha-sialidase activity positive regulation of catalytic activity galactolipid catabolic process ceramide catabolic process amide metabolic process glycosylceramide metabolic process galactolipid metabolic process ceramide metabolic process galactosylceramide catabolic process glycosylceramide catabolic process galactosylceramide metabolic process glucosylceramide metabolic process glucosylceramide catabolic process	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol protein-containing complex catalytic complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR001360	Glycoside hydrolase family 1	Family
A	IPR017853	Glycoside hydrolase superfamily	Homologous Superfamily
A	IPR033132	Glycosyl hydrolases family 1, N-terminal conserved site	Conserved Site

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: Q9H227	Drug abuse nephrosclerosis pancreatic intraductal papillary-mucinous neoplasm with low grade dysplasia substance abuse ulcerative colitis drug dependence hepatocellular carcinoma substance-related disorder malignant colon neoplasm pancreatic ductal adenocarcinoma Sjogren syndrome substance dependence

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.