Annotations: 3W6N

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Ras-like P-loop GTPases	8054357	3002022	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Ras-like P-loop GTPases	8054357	3002022	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Dynamin_N	e3w6nA1	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Dynamin_N	ECOD (1.6)
B	Dynamin_N	e3w6nB2	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Dynamin_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
B	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF01031	Dynamin central region (Dynamin_M)	Dynamin central region	-	Family
A, B	PF00350	Dynamin family (Dynamin_N)	Dynamin family	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Dynamin-1-like protein	small GTPase binding protein binding binding enzyme binding GTPase binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity cytoskeletal protein binding microtubule binding small GTPase binding protein binding binding enzyme binding GTPase binding GTPase regulator activity enzyme regulator activity enzyme activator activity GTPase activator activity molecular function activator activity nucleoside-triphosphatase regulator activity molecular function regulator activity cytoskeletal protein binding microtubule binding tubulin binding ubiquitin protein ligase binding ubiquitin-like protein ligase binding pyrophosphatase activity GTPase activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity identical protein binding GTP-dependent protein binding guanyl nucleotide binding GTP binding nucleotide binding guanyl ribonucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding organic cyclic compound binding purine nucleotide binding anion binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding protein homodimerization activity protein dimerization activity lipid binding	cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly cellular process cellular component organization or biogenesis regulation of biosynthetic process regulation of biological process regulation of cellular process cellular biosynthetic process cellular metabolic process biological regulation cellular component organization cellular component biogenesis cellular component assembly protein-containing complex organization protein complex oligomerization protein-containing complex assembly cellular process cellular component organization or biogenesis regulation of biosynthetic process regulation of biological process regulation of cellular process cellular biosynthetic process cellular metabolic process biological regulation regulation of cellular metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process regulation of cellular biosynthetic process regulation of gene expression biosynthetic process regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process regulation of metabolic process ribose phosphate metabolic process ATP metabolic process carbohydrate derivative metabolic process regulation of ATP metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process purine nucleotide metabolic process ribonucleotide metabolic process regulation of small molecule metabolic process nucleobase-containing small molecule metabolic process purine ribonucleoside triphosphate metabolic process regulation of nucleotide metabolic process regulation of phosphate metabolic process phosphate-containing compound metabolic process small molecule metabolic process regulation of nucleobase-containing compound metabolic process phosphorus metabolic process ribonucleoside triphosphate metabolic process nucleoside phosphate metabolic process purine nucleoside triphosphate metabolic process primary metabolic process nucleotide metabolic process regulation of purine nucleotide metabolic process purine-containing compound metabolic process organophosphate metabolic process regulation of phosphorus metabolic process nucleoside triphosphate metabolic process purine ribonucleotide metabolic process catabolic process macroautophagy autophagy regulation of mitophagy regulation of catabolic process regulation of autophagy cellular catabolic process regulation of macroautophagy mitophagy regulation of cellular catabolic process regulation of autophagy of mitochondrion process utilizing autophagic mechanism autophagy of mitochondrion regulation of cellular component organization regulation of organelle organization peroxisome organization regulation of peroxisome organization organelle organization mitochondrion distribution localization mitochondrion localization organelle localization intracellular distribution of mitochondria mitochondrion organization import into cell transport endocytosis establishment of localization vesicle-mediated transport establishment of organelle localization mitocytosis establishment of mitochondrion localization export from cell migracytosis peroxisome fission organelle fission cellular response to stimulus positive regulation of locomotion regulation of cell motility response to stimulus positive regulation of chemotaxis positive regulation of cell migration positive regulation of neutrophil chemotaxis taxis cell migration regulation of immune system process positive regulation of immune system process chemotaxis regulation of leukocyte chemotaxis regulation of leukocyte migration response to external stimulus positive regulation of leukocyte chemotaxis neutrophil migration granulocyte migration leukocyte migration positive regulation of granulocyte chemotaxis regulation of response to stimulus response to chemical regulation of locomotion regulation of neutrophil chemotaxis regulation of neutrophil migration regulation of response to external stimulus positive regulation of biological process neutrophil chemotaxis positive regulation of response to stimulus regulation of granulocyte chemotaxis positive regulation of response to external stimulus positive regulation of cell motility myeloid leukocyte migration regulation of cell migration cell motility locomotion positive regulation of cellular process cell chemotaxis positive regulation of leukocyte migration positive regulation of neutrophil migration regulation of chemotaxis cellular response to chemical stimulus immune system process granulocyte chemotaxis leukocyte chemotaxis heart process multicellular organismal process system process circulatory system process heart contraction blood circulation mitochondrial fragmentation involved in apoptotic process apoptotic mitochondrial changes apoptotic process cell death programmed cell death protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of protein localization positive regulation of establishment of protein localization positive regulation of secretion by cell protein localization to extracellular region positive regulation of protein transport regulation of secretion by cell secretion by cell positive regulation of secretion cellular macromolecule localization regulation of transport secretion regulation of establishment of protein localization establishment of protein localization to extracellular region regulation of protein transport protein secretion positive regulation of protein secretion regulation of protein secretion regulation of secretion positive regulation of transport protein transport regulation of cellular localization macromolecule localization positive regulation of protein localization rhythmic process positive regulation of organelle organization positive regulation of cellular component organization regulation of developmental process positive regulation of developmental process anatomical structure development regulation of anatomical structure morphogenesis developmental process mitochondrial fission anatomical structure morphogenesis regulation of mitochondrial fission regulation of mitochondrion organization positive regulation of mitochondrial fission protein localization to organelle protein localization to mitochondrion monoatomic ion transport monoatomic cation transport calcium ion transport metal ion transport necroptotic process programmed necrotic cell death mitochondrial membrane fission membrane organization membrane fission	clathrin-coated pit membrane cellular anatomical entity endomembrane system intracellular anatomical structure cytoplasm cytosol cluster of actin-based cell projections brush border membrane-bounded organelle intracellular organelle Golgi apparatus organelle intracellular membrane-bounded organelle clathrin-coated pit membrane cellular anatomical entity endomembrane system intracellular anatomical structure cytoplasm cytosol cluster of actin-based cell projections brush border membrane-bounded organelle intracellular organelle Golgi apparatus organelle intracellular membrane-bounded organelle peroxisome microbody perinuclear region of cytoplasm mitochondrial membrane mitochondrion organelle outer membrane organelle envelope bounding membrane of organelle mitochondrial envelope mitochondrial outer membrane outer membrane organelle membrane synapse intracellular vesicle transport vesicle membrane presynapse cytoplasmic vesicle vesicle membrane synaptic vesicle synaptic vesicle membrane cell junction vesicle transport vesicle exocytic vesicle membrane cytoplasmic vesicle membrane secretory vesicle exocytic vesicle polymeric cytoskeletal fiber cytoskeleton intracellular non-membrane-bounded organelle supramolecular fiber microtubule supramolecular polymer supramolecular complex microtubule cytoskeleton non-membrane-bounded organelle protein-containing complex organelle subcompartment endoplasmic reticulum subcompartment nuclear outer membrane-endoplasmic reticulum membrane network endoplasmic reticulum endoplasmic reticulum membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR020850	GTPase effector domain	Domain
A, B	IPR001401	Dynamin, GTPase domain	Domain
A, B	IPR045063	Dynamin, N-terminal	Domain
A, B	IPR019762	Dynamin, GTPase region, conserved site	Conserved Site
A, B	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A, B	IPR030381	Dynamin-type guanine nucleotide-binding (G) domain	Domain
A, B	IPR003130	Dynamin GTPase effector	Domain
A, B	IPR000375	Dynamin stalk domain	Domain
A, B	IPR022812	Dynamin	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: O00429	encephalopathy, lethal, due to defective mitochondrial peroxisomal fission 1 microcephaly mitochondrial encephalomyopathy optic atrophy 5 acquired lactic acidosis optic atrophy coronary artery disease hereditary spastic paraplegia Severe Congenital Microcephaly atrial fibrillation lactic acidosis microlissencephaly myocardial ischemia autosomal dominant optic atrophy lung cancer encephalopathy, lethal, due to defective mitochondrial peroxisomal fission 1 microcephaly mitochondrial encephalomyopathy optic atrophy 5 acquired lactic acidosis optic atrophy coronary artery disease hereditary spastic paraplegia Severe Congenital Microcephaly atrial fibrillation lactic acidosis microlissencephaly myocardial ischemia autosomal dominant optic atrophy lung cancer neurodegenerative disease peroxisomal disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.