3WBG

Structure of the human heart fatty acid-binding protein in complex with 1-anilinonaphtalene-8-sulphonic acid

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d3wbga_	All beta proteins	Lipocalins	Lipocalins	Fatty acid binding protein-like	Muscle fatty acid binding protein (m-fabp)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d3wbgb_	All beta proteins	Lipocalins	Lipocalins	Fatty acid binding protein-like	Muscle fatty acid binding protein (m-fabp)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
C	d3wbgc_	All beta proteins	Lipocalins	Lipocalins	Fatty acid binding protein-like	Muscle fatty acid binding protein (m-fabp)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
D	d3wbgd_	All beta proteins	Lipocalins	Lipocalins	Fatty acid binding protein-like	Muscle fatty acid binding protein (m-fabp)	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Lipocalins	8042642	3001332	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Lipocalins	8042642	3001332	SCOP2B (2022-06-29)
C	SCOP2B Superfamily	Lipocalins	8042642	3001332	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Lipocalins	8042642	3001332	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Lipocalin_7	e3wbgA1	A: beta barrels	X: Lipocalins/Streptavidin	H: Lipocalins (From Topology)	T: Lipocalins	F: Lipocalin_7	ECOD (1.6)
B	Lipocalin_7	e3wbgB1	A: beta barrels	X: Lipocalins/Streptavidin	H: Lipocalins (From Topology)	T: Lipocalins	F: Lipocalin_7	ECOD (1.6)
C	Lipocalin_7	e3wbgC1	A: beta barrels	X: Lipocalins/Streptavidin	H: Lipocalins (From Topology)	T: Lipocalins	F: Lipocalin_7	ECOD (1.6)
D	Lipocalin_7	e3wbgD1	A: beta barrels	X: Lipocalins/Streptavidin	H: Lipocalins (From Topology)	T: Lipocalins	F: Lipocalin_7	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.128.20	Mainly Beta	Beta Barrel	Lipocalin	Calycin beta-barrel core domain	CATH (4.3.0)
B	2.40.128.20	Mainly Beta	Beta Barrel	Lipocalin	Calycin beta-barrel core domain	CATH (4.3.0)
C	2.40.128.20	Mainly Beta	Beta Barrel	Lipocalin	Calycin beta-barrel core domain	CATH (4.3.0)
D	2.40.128.20	Mainly Beta	Beta Barrel	Lipocalin	Calycin beta-barrel core domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00061	Lipocalin / cytosolic fatty-acid binding protein family (Lipocalin)	Lipocalin / cytosolic fatty-acid binding protein family	Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid ...	Lipocalins are transporters for small hydrophobic molecules, such as lipids, steroid hormones, bilins, and retinoids. The family also encompasses the enzyme prostaglandin D synthase (EC:5.3.99.2). Alignment subsumes both the lipocalin and fatty acid binding protein signatures from PROSITE. This is supported on structural and functional grounds. The structure is an eight-stranded beta barrel.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	Fatty acid-binding protein, heart	fatty acid binding organic acid binding binding ion binding anion binding long-chain fatty acid binding lipid binding carboxylic acid binding monocarboxylic acid binding small molecule binding cytoskeletal protein binding protein binding oleic acid binding	regulation of cellular process regulation of lipid metabolic process positive regulation of biological process lipid biosynthetic process positive regulation of phosphate metabolic process regulation of primary metabolic process phospholipid metabolic process positive regulation of metabolic process positive regulation of biosynthetic process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of lipid metabolic process phosphorus metabolic process positive regulation of cellular process regulation of cellular process regulation of lipid metabolic process positive regulation of biological process lipid biosynthetic process positive regulation of phosphate metabolic process regulation of primary metabolic process phospholipid metabolic process positive regulation of metabolic process positive regulation of biosynthetic process regulation of phosphate metabolic process phosphate-containing compound metabolic process positive regulation of lipid metabolic process phosphorus metabolic process positive regulation of cellular process regulation of biosynthetic process regulation of biological process positive regulation of phosphorus metabolic process biological regulation positive regulation of phospholipid biosynthetic process regulation of phospholipid metabolic process primary metabolic process phospholipid biosynthetic process regulation of phospholipid biosynthetic process positive regulation of phospholipid metabolic process biosynthetic process positive regulation of lipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process metabolic process cellular process regulation of phosphorus metabolic process regulation of lipid biosynthetic process regulation of metabolic process lipid metabolic process cellular localization intracellular lipid transport transport lipid localization lipid transport intracellular transport establishment of localization localization macromolecule localization establishment of localization in cell phospholipid homeostasis chemical homeostasis homeostatic process lipid homeostasis glycerophospholipid metabolic process phosphatidylcholine metabolic process glycerophospholipid biosynthetic process regulation of phosphatidylcholine metabolic process glycerolipid biosynthetic process glycerolipid metabolic process phosphatidylcholine biosynthetic process regulation of phosphatidylcholine biosynthetic process negative regulation of cell population proliferation cell population proliferation regulation of cell population proliferation negative regulation of cellular process negative regulation of biological process organic anion transport carboxylic acid transport organic acid transport monocarboxylic acid transport fatty acid transport long-chain fatty acid transport developmental process fat cell differentiation cellular developmental process brown fat cell differentiation cell differentiation regulation of localization import into cell regulation of lipid transport lipid import into cell long-chain fatty acid import into cell regulation of transport regulation of long-chain fatty acid import into cell positive regulation of lipid localization regulation of fatty acid transport positive regulation of organic acid transport positive regulation of lipid transport positive regulation of transport regulation of lipid localization positive regulation of long-chain fatty acid import into cell regulation of organic acid transport positive regulation of fatty acid transport oxoacid metabolic process ketone metabolic process organic acid metabolic process regulation of fatty acid oxidation fatty acid oxidation regulation of small molecule metabolic process small molecule metabolic process lipid oxidation fatty acid metabolic process carboxylic acid metabolic process lipid modification regulation of ketone metabolic process regulation of fatty acid metabolic process monocarboxylic acid metabolic process sterol homeostasis cholesterol homeostasis	extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol intracellular organelle extracellular exosome membrane-bounded organelle extracellular vesicle cellular anatomical structure extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular anatomical structure cytoplasm cytosol intracellular organelle nucleus intracellular membrane-bounded organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR000463	Cytosolic fatty-acid binding	Domain
A, B, C, D	IPR012674	Calycin	Homologous Superfamily
A, B, C, D	IPR031259	Intracellular lipid binding protein	Family
A, B, C, D	IPR000566	Lipocalin/cytosolic fatty-acid binding domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: P05413	myopathy Necrosis oligodendroglioma pilocytic astrocytoma psoriasis astrocytic tumor dermatomyositis juvenile dermatomyositis lung cancer malignant glioma medulloblastoma osteosarcoma pituitary cancer schizophrenia atypical teratoid rhabdoid tumor myopathy Necrosis oligodendroglioma pilocytic astrocytoma psoriasis astrocytic tumor dermatomyositis juvenile dermatomyositis lung cancer malignant glioma medulloblastoma osteosarcoma pituitary cancer schizophrenia atypical teratoid rhabdoid tumor gastric carcinoma large cell medulloblastoma lung carcinoma malignant mesothelioma muscle tissue disease Pick disease primitive neuroectodermal tumor ulcerative colitis Crohn disease glioblastoma limb-girdle muscular dystrophy malignant ependymoma MALT lymphoma muscular disease

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.