Annotations: 3ZX2

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
B	GDA1_CD39_C	e3zx2B3	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: GDA1_CD39_C	ECOD (1.6)
B	GDA1_CD39_N	e3zx2B4	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: GDA1_CD39_N	ECOD (1.6)
A	GDA1_CD39_C	e3zx2A7	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: GDA1_CD39_C	ECOD (1.6)
A	GDA1_CD39_N	e3zx2A8	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: GDA1_CD39_N	ECOD (1.6)
C	GDA1_CD39_C	e3zx2C7	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: GDA1_CD39_C	ECOD (1.6)
C	GDA1_CD39_N	e3zx2C8	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: GDA1_CD39_N	ECOD (1.6)
D	GDA1_CD39_C	e3zx2D5	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: GDA1_CD39_C	ECOD (1.6)
D	GDA1_CD39_N	e3zx2D6	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: GDA1_CD39_N	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
B	3.30.420.40	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
B	3.30.420.150	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
A	3.30.420.40	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
A	3.30.420.150	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
C	3.30.420.40	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
C	3.30.420.150	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
D	3.30.420.40	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
D	3.30.420.150	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	ECTONUCLEOSIDE TRIPHOSPHATE DIPHOSPHOHYDROLASE 1	pyrophosphatase activity nucleoside diphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity GDP phosphatase activity apyrase activity ribonucleoside triphosphate phosphatase activity CTPase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding pyrophosphatase activity nucleoside diphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity GDP phosphatase activity apyrase activity ribonucleoside triphosphate phosphatase activity CTPase activity binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding ADP phosphatase activity UDP phosphatase activity ATP hydrolysis activity ATP-dependent activity ITPase activity CDP phosphatase activity GTPase activity identical protein binding protein binding IDP phosphatase activity	cellular response to stimulus cellular response to metal ion cellular response to chemical stimulus response to stimulus response to metal ion response to aluminum ion response to chemical cellular response to aluminum ion cellular process catabolic process organophosphate catabolic process nucleoside phosphate catabolic process nucleobase-containing compound metabolic process nucleobase-containing small molecule metabolic process cellular response to stimulus cellular response to metal ion cellular response to chemical stimulus response to stimulus response to metal ion response to aluminum ion response to chemical cellular response to aluminum ion cellular process catabolic process organophosphate catabolic process nucleoside phosphate catabolic process nucleobase-containing compound metabolic process nucleobase-containing small molecule metabolic process phosphate-containing compound metabolic process ribonucleoside diphosphate metabolic process ribonucleoside diphosphate catabolic process small molecule metabolic process phosphorus metabolic process nucleoside phosphate metabolic process cellular metabolic process purine nucleoside diphosphate metabolic process primary metabolic process nucleobase-containing compound catabolic process nucleoside diphosphate metabolic process organophosphate metabolic process purine nucleoside diphosphate catabolic process purine ribonucleoside diphosphate metabolic process nucleoside diphosphate catabolic process metabolic process purine ribonucleoside diphosphate catabolic process response to nitrogen compound response to purine-containing compound response to organic cyclic compound response to caffeine response to alkaloid biological process involved in interspecies interaction between organisms response to lipid response to other organism cellular response to lipopolysaccharide response to oxygen-containing compound response to external stimulus cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound response to biotic stimulus cellular response to biotic stimulus response to bacterium cellular response to lipid response to external biotic stimulus response to molecule of bacterial origin multicellular organismal process regulation of body fluid levels wound healing homotypic cell-cell adhesion cell activation hemostasis biological regulation platelet aggregation blood coagulation cell adhesion cell-cell adhesion response to stress coagulation regulation of biological quality response to wounding platelet activation ribose phosphate metabolic process ribonucleotide catabolic process carbohydrate derivative metabolic process purine nucleotide metabolic process ribonucleotide metabolic process purine ribonucleotide catabolic process nucleotide catabolic process purine nucleotide catabolic process carbohydrate derivative catabolic process ADP catabolic process purine-containing compound catabolic process nucleotide metabolic process purine-containing compound metabolic process ADP metabolic process purine ribonucleotide metabolic process response to peptide response to interferon-alpha response to cytokine cellular response to cytokine stimulus cellular response to interferon-alpha monoamine transport regulation of localization nitrogen compound transport regulation of cellular process negative regulation of amine transport transport signaling regulation of catecholamine secretion negative regulation of biological process negative regulation of transport organic hydroxy compound transport dopamine transport cell communication localization secretion by cell regulation of secretion by cell negative regulation of secretion catecholamine transport negative regulation of dopamine secretion signal release negative regulation of cellular process negative regulation of secretion by cell regulation of biological process secretion regulation of transport export from cell cell-cell signaling negative regulation of catecholamine secretion dopamine secretion establishment of localization regulation of secretion catecholamine secretion amine transport regulation of amine transport regulation of dopamine secretion response to acid chemical response to amino acid response to proline cellular response to tumor necrosis factor response to tumor necrosis factor response to auditory stimulus response to mechanical stimulus response to abiotic stimulus response to organophosphorus response to ATP response to ionizing radiation response to radiation response to gamma radiation G protein-coupled receptor signaling pathway signal transduction response to L-arginine negative regulation of small molecule metabolic process nucleotide biosynthetic process purine ribonucleotide biosynthetic process negative regulation of ATP metabolic process purine ribonucleoside triphosphate biosynthetic process regulation of nucleotide biosynthetic process negative regulation of cellular metabolic process regulation of primary metabolic process regulation of ATP metabolic process ribonucleotide biosynthetic process negative regulation of nucleotide metabolic process purine nucleoside triphosphate biosynthetic process regulation of small molecule metabolic process negative regulation of nucleotide biosynthetic process regulation of nucleotide metabolic process regulation of phosphate metabolic process negative regulation of nucleobase-containing compound metabolic process regulation of nucleobase-containing compound metabolic process ribose phosphate biosynthetic process negative regulation of metabolic process regulation of cellular metabolic process regulation of purine nucleotide metabolic process ribonucleoside triphosphate biosynthetic process biosynthetic process organophosphate biosynthetic process nucleoside phosphate biosynthetic process regulation of phosphorus metabolic process nucleoside triphosphate metabolic process regulation of metabolic process purine nucleotide biosynthetic process ATP metabolic process negative regulation of purine nucleotide metabolic process ATP biosynthetic process negative regulation of phosphate metabolic process negative regulation of ATP biosynthetic process negative regulation of purine nucleotide biosynthetic process purine-containing compound biosynthetic process purine ribonucleoside triphosphate metabolic process ribonucleoside triphosphate metabolic process regulation of biosynthetic process purine nucleoside triphosphate metabolic process carbohydrate derivative biosynthetic process regulation of purine nucleotide biosynthetic process nucleoside triphosphate biosynthetic process nucleobase-containing compound biosynthetic process regulation of ATP biosynthetic process negative regulation of biosynthetic process negative regulation of phosphorus metabolic process	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane synapse cell junction plasma membrane region synaptic membrane basement membrane extracellular matrix external encapsulating structure cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane synapse cell junction plasma membrane region synaptic membrane basement membrane extracellular matrix external encapsulating structure collagen-containing extracellular matrix membrane microdomain membrane raft plasma membrane raft caveola basal part of cell basal plasma membrane basolateral plasma membrane somatodendritic compartment cell body neuronal cell body extracellular region extracellular space membrane-bounded organelle intracellular anatomical structure transport vesicle intracellular vesicle intracellular membrane-bounded organelle endomembrane system intracellular organelle presynapse cytoplasmic vesicle synaptic vesicle organelle secretory vesicle cytoplasm vesicle exocytic vesicle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR000407	Nucleoside phosphatase GDA1/CD39	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.