Annotations: 3ZYV

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Fer2_2	e3zyvA3	A: alpha bundles	X: CO dehydrogenase ISP C-domain like (From Topology)	H: CO dehydrogenase ISP C-domain like (From Topology)	T: CO dehydrogenase ISP C-domain like	F: Fer2_2	ECOD (1.6)
A	Fer2	e3zyvA4	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: Fer2	ECOD (1.6)
A	Ald_Xan_dh_C2	e3zyvA1	A: a+b two layers	X: MocoBD/DmpA-related (From Homology)	H: MocoBD/DmpA-related	T: Molybdenum cofactor-binding domain	F: Ald_Xan_dh_C2	ECOD (1.6)
A	CO_deh_flav_C	e3zyvA16	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: SufE/NifU (From Topology)	T: SufE/NifU	F: CO_deh_flav_C	ECOD (1.6)
A	FAD_binding_5	e3zyvA18	A: a+b complex topology	X: FAD-binding domain-like	H: FAD-binding domain (From Topology)	T: FAD-binding domain	F: FAD_binding_5	ECOD (1.6)
A	Ald_Xan_dh_C	e3zyvA15	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: CO dehydrogenase molybdoprotein N-domain-like	F: Ald_Xan_dh_C	ECOD (1.6)
B	Fer2_2	e3zyvB8	A: alpha bundles	X: CO dehydrogenase ISP C-domain like (From Topology)	H: CO dehydrogenase ISP C-domain like (From Topology)	T: CO dehydrogenase ISP C-domain like	F: Fer2_2	ECOD (1.6)
B	Fer2	e3zyvB7	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: Fer2	ECOD (1.6)
B	Ald_Xan_dh_C2	e3zyvB9	A: a+b two layers	X: MocoBD/DmpA-related (From Homology)	H: MocoBD/DmpA-related	T: Molybdenum cofactor-binding domain	F: Ald_Xan_dh_C2	ECOD (1.6)
B	CO_deh_flav_C	e3zyvB6	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: SufE/NifU (From Topology)	T: SufE/NifU	F: CO_deh_flav_C	ECOD (1.6)
B	FAD_binding_5	e3zyvB4	A: a+b complex topology	X: FAD-binding domain-like	H: FAD-binding domain (From Topology)	T: FAD-binding domain	F: FAD_binding_5	ECOD (1.6)
B	Ald_Xan_dh_C	e3zyvB5	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: CO dehydrogenase molybdoprotein N-domain-like	F: Ald_Xan_dh_C	ECOD (1.6)
C	Fer2_2	e3zyvC6	A: alpha bundles	X: CO dehydrogenase ISP C-domain like (From Topology)	H: CO dehydrogenase ISP C-domain like (From Topology)	T: CO dehydrogenase ISP C-domain like	F: Fer2_2	ECOD (1.6)
C	Fer2	e3zyvC5	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: Fer2	ECOD (1.6)
C	Ald_Xan_dh_C2	e3zyvC4	A: a+b two layers	X: MocoBD/DmpA-related (From Homology)	H: MocoBD/DmpA-related	T: Molybdenum cofactor-binding domain	F: Ald_Xan_dh_C2	ECOD (1.6)
C	CO_deh_flav_C	e3zyvC20	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: SufE/NifU (From Topology)	T: SufE/NifU	F: CO_deh_flav_C	ECOD (1.6)
C	FAD_binding_5	e3zyvC22	A: a+b complex topology	X: FAD-binding domain-like	H: FAD-binding domain (From Topology)	T: FAD-binding domain	F: FAD_binding_5	ECOD (1.6)
C	Ald_Xan_dh_C	e3zyvC19	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: CO dehydrogenase molybdoprotein N-domain-like	F: Ald_Xan_dh_C	ECOD (1.6)
D	Fer2_2	e3zyvD6	A: alpha bundles	X: CO dehydrogenase ISP C-domain like (From Topology)	H: CO dehydrogenase ISP C-domain like (From Topology)	T: CO dehydrogenase ISP C-domain like	F: Fer2_2	ECOD (1.6)
D	Fer2	e3zyvD5	A: a+b two layers	X: beta-Grasp	H: Ubiquitin-related	T: Ubiquitin-like	F: Fer2	ECOD (1.6)
D	Ald_Xan_dh_C2	e3zyvD3	A: a+b two layers	X: MocoBD/DmpA-related (From Homology)	H: MocoBD/DmpA-related	T: Molybdenum cofactor-binding domain	F: Ald_Xan_dh_C2	ECOD (1.6)
D	CO_deh_flav_C	e3zyvD20	A: a+b two layers	X: FAD-linked reductases, C-terminal domain-like	H: SufE/NifU (From Topology)	T: SufE/NifU	F: CO_deh_flav_C	ECOD (1.6)
D	FAD_binding_5	e3zyvD22	A: a+b complex topology	X: FAD-binding domain-like	H: FAD-binding domain (From Topology)	T: FAD-binding domain	F: FAD_binding_5	ECOD (1.6)
D	Ald_Xan_dh_C	e3zyvD19	A: a+b complex topology	X: alpha/beta-Hammerhead/Barrel-sandwich hybrid	H: alpha/beta-Hammerhead/Barrel-sandwich hybrid	T: CO dehydrogenase molybdoprotein N-domain-like	F: Ald_Xan_dh_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.10.20.30	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Beta-grasp domain	CATH (4.3.0)
A	1.10.150.120	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
A	3.30.43.10	Alpha Beta	2-Layer Sandwich	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase	domain 2	CATH (4.3.0)
A	3.30.390.50	Alpha Beta	2-Layer Sandwich	Enolase-like	domain 1	CATH (4.3.0)
A	3.30.365.10	Alpha Beta	2-Layer Sandwich	Aldehyde Oxidoreductase	domain 4	CATH (4.3.0)
A	3.90.1170.50	Alpha Beta	Alpha-Beta Complex	Aldehyde Oxidoreductase	domain 3	CATH (4.3.0)
B	3.10.20.30	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Beta-grasp domain	CATH (4.3.0)
B	1.10.150.120	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
B	3.30.43.10	Alpha Beta	2-Layer Sandwich	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase	domain 2	CATH (4.3.0)
B	3.30.390.50	Alpha Beta	2-Layer Sandwich	Enolase-like	domain 1	CATH (4.3.0)
B	3.30.365.10	Alpha Beta	2-Layer Sandwich	Aldehyde Oxidoreductase	domain 4	CATH (4.3.0)
B	3.90.1170.50	Alpha Beta	Alpha-Beta Complex	Aldehyde Oxidoreductase	domain 3	CATH (4.3.0)
C	3.10.20.30	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Beta-grasp domain	CATH (4.3.0)
C	1.10.150.120	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
C	3.30.43.10	Alpha Beta	2-Layer Sandwich	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase	domain 2	CATH (4.3.0)
C	3.30.390.50	Alpha Beta	2-Layer Sandwich	Enolase-like	domain 1	CATH (4.3.0)
C	3.30.365.10	Alpha Beta	2-Layer Sandwich	Aldehyde Oxidoreductase	domain 4	CATH (4.3.0)
C	3.90.1170.50	Alpha Beta	Alpha-Beta Complex	Aldehyde Oxidoreductase	domain 3	CATH (4.3.0)
D	3.10.20.30	Alpha Beta	Roll	Ubiquitin-like (UB roll)	Beta-grasp domain	CATH (4.3.0)
D	1.10.150.120	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
D	3.30.43.10	Alpha Beta	2-Layer Sandwich	Uridine Diphospho-n-acetylenolpyruvylglucosamine Reductase	domain 2	CATH (4.3.0)
D	3.30.390.50	Alpha Beta	2-Layer Sandwich	Enolase-like	domain 1	CATH (4.3.0)
D	3.30.365.10	Alpha Beta	2-Layer Sandwich	Aldehyde Oxidoreductase	domain 4	CATH (4.3.0)
D	3.90.1170.50	Alpha Beta	Alpha-Beta Complex	Aldehyde Oxidoreductase	domain 3	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF00941	FAD binding domain in molybdopterin dehydrogenase (FAD_binding_5)	FAD binding domain in molybdopterin dehydrogenase	-	Family
A, B, C, D	PF01315	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain (Ald_Xan_dh_C)	Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain	-	Domain
A, B, C, D	PF01799	[2Fe-2S] binding domain (Fer2_2)	[2Fe-2S] binding domain	-	Domain
A, B, C, D	PF20256	Molybdopterin cofactor-binding domain (MoCoBD_2)	Molybdopterin cofactor-binding domain	-	Domain
A, B, C, D	PF03450	CO dehydrogenase flavoprotein C-terminal domain (CO_deh_flav_C)	CO dehydrogenase flavoprotein C-terminal domain	-	Domain
A, B, C, D	PF02738	Molybdopterin cofactor-binding domain (MoCoBD_1)	Molybdopterin cofactor-binding domain	-	Domain
A, B, C, D	PF00111	2Fe-2S iron-sulfur cluster binding domain (Fer2)	2Fe-2S iron-sulfur cluster binding domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	AOX3	FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity aldehyde oxidase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors catalytic activity FAD binding flavin adenine dinucleotide binding binding nucleoside phosphate binding ion binding organic cyclic compound binding anion binding nucleotide binding heterocyclic compound binding small molecule binding oxidoreductase activity aldehyde oxidase activity oxidoreductase activity, acting on the aldehyde or oxo group of donors catalytic activity oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor electron transfer activity identical protein binding protein binding protein homodimerization activity protein dimerization activity iron-sulfur cluster binding 2 iron, 2 sulfur cluster binding metal cluster binding cation binding transition metal ion binding iron ion binding metal ion binding molybdenum ion binding molybdopterin cofactor binding NAD binding purine nucleotide binding adenyl nucleotide binding	cellular response to stimulus cellular response to chemical stimulus response to stimulus response to chemical cellular response to xenobiotic stimulus metabolic process cellular process xenobiotic metabolic process response to xenobiotic stimulus	cellular anatomical structure intracellular anatomical structure cytoplasm cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR016167	FAD-binding, type PCMH, subdomain 1	Homologous Superfamily
A, B, C, D	IPR001041	2Fe-2S ferredoxin-type iron-sulfur binding domain	Domain
A, B, C, D	IPR006058	2Fe-2S ferredoxin, iron-sulphur binding site	Binding Site
A, B, C, D	IPR046867	Aldehyde oxidase/xanthine dehydrogenase, second molybdopterin binding domain	Domain
A, B, C, D	IPR002888	[2Fe-2S]-binding	Domain
A, B, C, D	IPR036318	FAD-binding, type PCMH-like superfamily	Homologous Superfamily
A, B, C, D	IPR016208	Aldehyde oxidase/xanthine dehydrogenase-like	Family
A, B, C, D	IPR012675	Beta-grasp domain superfamily	Homologous Superfamily
A, B, C, D	IPR036683	CO dehydrogenase flavoprotein, C-terminal domain superfamily	Homologous Superfamily
A, B, C, D	IPR036010	2Fe-2S ferredoxin-like superfamily	Homologous Superfamily
A, B, C, D	IPR000674	Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead	Domain
A, B, C, D	IPR036856	Aldehyde oxidase/xanthine dehydrogenase, a/b hammerhead superfamily	Homologous Superfamily
A, B, C, D	IPR014313	Aldehyde oxidase	Family
A, B, C, D	IPR037165	Aldehyde oxidase/xanthine dehydrogenase, molybdopterin binding domain superfamily	Homologous Superfamily
A, B, C, D	IPR016166	FAD-binding domain, PCMH-type	Domain
A, B, C, D	IPR002346	Molybdopterin dehydrogenase, FAD-binding	Domain
A, B, C, D	IPR016169	FAD-binding, type PCMH, subdomain 2	Homologous Superfamily
A, B, C, D	IPR036884	[2Fe-2S]-binding domain superfamily	Homologous Superfamily
A, B, C, D	IPR008274	Aldehyde oxidase/xanthine dehydrogenase, first molybdopterin binding domain	Domain
A, B, C, D	IPR005107	CO dehydrogenase flavoprotein, C-terminal	Domain

3ZYV

Crystal structure of the mouse liver Aldehyde Oxidase 3 (mAOX3)

External Resource: Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage

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3ZYV

Crystal structure of the mouse liver Aldehyde Oxidase 3 (mAOX3)

External Resource: Annotation

Domain Annotation: ECOD Classification ECOD Database Homepage

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

InterPro: Protein Family Classification InterPro Database Homepage