4A5Z

Structures of MITD1

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Phospholipase D/nuclease-like	8092078	3000664	SCOP2B (2022-06-29)
C	SCOP2 Family	MIT C-terminal domain-like	8045785	4004684	SCOP2 (2022-06-29)
C	SCOP2 Superfamily	Phospholipase D/nuclease-like	8092078	3000664	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Phospholipase D/nuclease-like	8092078	3000664	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Phospholipase D/nuclease-like	8092078	3000664	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	MIT_C	e4a5zA1	A: a+b three layers	X: Phospholipase D/nuclease (From Topology)	H: Phospholipase D/nuclease (From Topology)	T: Phospholipase D/nuclease	F: MIT_C	ECOD (1.6)
C	MIT_C	e4a5zC1	A: a+b three layers	X: Phospholipase D/nuclease (From Topology)	H: Phospholipase D/nuclease (From Topology)	T: Phospholipase D/nuclease	F: MIT_C	ECOD (1.6)
B	MIT_C	e4a5zB1	A: a+b three layers	X: Phospholipase D/nuclease (From Topology)	H: Phospholipase D/nuclease (From Topology)	T: Phospholipase D/nuclease	F: MIT_C	ECOD (1.6)
D	MIT_C	e4a5zD1	A: a+b three layers	X: Phospholipase D/nuclease (From Topology)	H: Phospholipase D/nuclease (From Topology)	T: Phospholipase D/nuclease	F: MIT_C	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.870.30	Alpha Beta	2-Layer Sandwich	Endonuclease	Chain A	CATH (4.3.0)
C	3.30.870.30	Alpha Beta	2-Layer Sandwich	Endonuclease	Chain A	CATH (4.3.0)
B	3.30.870.30	Alpha Beta	2-Layer Sandwich	Endonuclease	Chain A	CATH (4.3.0)
D	3.30.870.30	Alpha Beta	2-Layer Sandwich	Endonuclease	Chain A	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, C, D	PF16565	Phospholipase D-like domain at C-terminus of MIT (MIT_C)	Phospholipase D-like domain at C-terminus of MIT	MIT_C is the C-terminal domain of MIT-containing proteins, Pfam:PF04212. It contains an unanticipated phospholipase d fold (PLD fold) that binds avidly to phosphoinositide-containing membranes [1]. It is conserved in eukaryotes, though not fungi and ...	MIT_C is the C-terminal domain of MIT-containing proteins, Pfam:PF04212. It contains an unanticipated phospholipase d fold (PLD fold) that binds avidly to phosphoinositide-containing membranes [1]. It is conserved in eukaryotes, though not fungi and plants, and some bacteria.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, C, D	MIT DOMAIN-CONTAINING PROTEIN 1	binding phospholipid binding lipid binding phosphatidylinositol binding protein binding protein domain specific binding identical protein binding	mitotic cell cycle process cytoskeleton-dependent cytokinesis mitotic cytokinesis cellular process cytokinesis cell division cell cycle mitotic cell cycle cell cycle process regulation of protein binding regulation of molecular function negative regulation of protein binding negative regulation of binding regulation of binding mitotic cell cycle process cytoskeleton-dependent cytokinesis mitotic cytokinesis cellular process cytokinesis cell division cell cycle mitotic cell cycle cell cycle process regulation of protein binding regulation of molecular function negative regulation of protein binding negative regulation of binding regulation of binding biological regulation negative regulation of molecular function membrane organization mitotic cytokinetic process cellular component organization midbody abscission cytokinetic process cellular component organization or biogenesis	midbody cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular organelle intracellular anatomical structure midbody cellular anatomical structure membrane extracellular exosome membrane-bounded organelle extracellular vesicle extracellular organelle extracellular region organelle extracellular space vesicle extracellular membrane-bounded organelle intracellular organelle intracellular anatomical structure intracellular membrane-bounded organelle endosome membrane endosome intracellular vesicle late endosome membrane endomembrane system cytoplasmic vesicle membrane bounding membrane of organelle cytoplasmic vesicle vesicle membrane late endosome cytoplasm organelle membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, C, D	IPR007330	MIT domain	Domain
A, B, C, D	IPR032341	MITD1, C-terminal phospholipase D-like domain	Domain
A, B, C, D	IPR036181	MIT domain superfamily	Homologous Superfamily
A, B, C, D	IPR038113	MITD1, C-terminal phospholipase D-like domain superfamily	Homologous Superfamily
A, B, C, D	IPR045331	MITD1, N-terminal domain	Domain
A, B, C, D	IPR052817	MIT domain-containing protein 1	Family

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B, C, D	Pharos: Q8WV92	adenoma myopathy progressive supranuclear palsy juvenile dermatomyositis ovarian cancer Sjogren syndrome medulloblastoma pancreatic intraductal papillary-mucinous neoplasm

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.