4A6N
STRUCTURE OF THE TETRACYCLINE DEGRADING MONOOXYGENASE TETX IN COMPLEX WITH TIGECYCLINE
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | EUF08298 | e4a6nA2 | A: a+b two layers | X: FAD-linked reductases, C-terminal domain-like | H: FAD-linked reductases-C (From Topology) | T: FAD-linked reductases-C | F: EUF08298 | ECOD (1.6) |
A | FAD_binding_3_3rd_1 | e4a6nA1 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: FAD/NAD(P)-binding domain | F: FAD_binding_3_3rd_1 | ECOD (1.6) |
B | EUF08298 | e4a6nB1 | A: a+b two layers | X: FAD-linked reductases, C-terminal domain-like | H: FAD-linked reductases-C (From Topology) | T: FAD-linked reductases-C | F: EUF08298 | ECOD (1.6) |
B | FAD_binding_3_3rd_1 | e4a6nB2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: FAD/NAD(P)-binding domain | F: FAD_binding_3_3rd_1 | ECOD (1.6) |
D | EUF08298 | e4a6nD1 | A: a+b two layers | X: FAD-linked reductases, C-terminal domain-like | H: FAD-linked reductases-C (From Topology) | T: FAD-linked reductases-C | F: EUF08298 | ECOD (1.6) |
D | FAD_binding_3_3rd_1 | e4a6nD2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: FAD/NAD(P)-binding domain | F: FAD_binding_3_3rd_1 | ECOD (1.6) |
C | EUF08298 | e4a6nC1 | A: a+b two layers | X: FAD-linked reductases, C-terminal domain-like | H: FAD-linked reductases-C (From Topology) | T: FAD-linked reductases-C | F: EUF08298 | ECOD (1.6) |
C | FAD_binding_3_3rd_1 | e4a6nC2 | A: a/b three-layered sandwiches | X: Rossmann-like | H: Rossmann-related | T: FAD/NAD(P)-binding domain | F: FAD_binding_3_3rd_1 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.50.50.60 | Alpha Beta | 3-Layer(bba) Sandwich | FAD/NAD(P)-binding domain | FAD/NAD(P)-binding domain | CATH (4.3.0) |
B | 3.50.50.60 | Alpha Beta | 3-Layer(bba) Sandwich | FAD/NAD(P)-binding domain | FAD/NAD(P)-binding domain | CATH (4.3.0) |
D | 3.50.50.60 | Alpha Beta | 3-Layer(bba) Sandwich | FAD/NAD(P)-binding domain | FAD/NAD(P)-binding domain | CATH (4.3.0) |
C | 3.50.50.60 | Alpha Beta | 3-Layer(bba) Sandwich | FAD/NAD(P)-binding domain | FAD/NAD(P)-binding domain | CATH (4.3.0) |
AMR Gene Family: CARD Annotation CARD Database Homepage
Chains | Accession | Gene Family | Drug Class | Resistance Machanism | Provenance Source (Version) |
---|---|---|---|---|---|
ARO:3000036 | tetracycline inactivation enzyme | glycylcycline, tetracycline antibiotic | antibiotic inactivation | CARD (3.3.0) | |
ARO:3000036 | tetracycline inactivation enzyme | glycylcycline, tetracycline antibiotic | antibiotic inactivation | CARD (3.3.0) | |
ARO:3000036 | tetracycline inactivation enzyme | glycylcycline, tetracycline antibiotic | antibiotic inactivation | CARD (3.3.0) | |
ARO:3000036 | tetracycline inactivation enzyme | glycylcycline, tetracycline antibiotic | antibiotic inactivation | CARD (3.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF01494 | FAD binding domain (FAD_binding_3) | FAD binding domain | - | Family | |
PF01494 | FAD binding domain (FAD_binding_3) | FAD binding domain | - | Family |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
Chains | Polymer | Molecular Function | Biological Process | Cellular Component |
---|---|---|---|---|
TETX2 PROTEIN | ||||
TETX2 PROTEIN |
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR002938 | FAD-binding domain | Domain | |
IPR043683 | Flavin-dependent monooxygenase TetX | Family | |
IPR036188 | FAD/NAD(P)-binding domain superfamily | Homologous Superfamily | |
IPR002938 | FAD-binding domain | Domain | |
IPR043683 | Flavin-dependent monooxygenase TetX | Family | |
IPR036188 | FAD/NAD(P)-binding domain superfamily | Homologous Superfamily |