4BVV

Identification of small molecule inhibitors selective for apo(a) kringles KIV-7, KIV-10 and KV.

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4bvva_	Small proteins	Kringle-like	Kringle-like	Kringle modules	automated matches	HUMAN (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Kringle	e4bvvA1	A: few secondary structure elements	X: Kringle-like (From Topology)	H: Kringle-like (From Topology)	T: Kringle-like	F: Kringle	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	2.40.20.10	Mainly Beta	Beta Barrel	Plasminogen Kringle 4	Plasminogen Kringle 4	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00051	Kringle domain (Kringle)	Kringle domain	Kringle domains have been found in plasminogen, hepatocyte growth factors, prothrombin, and apolipoprotein A. Structure is disulfide-rich, nearly all-beta.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	APOLIPOPROTEIN(A)	protein binding binding signaling receptor binding apolipoprotein binding peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity enzyme regulator activity molecular function inhibitor activity protein binding binding signaling receptor binding apolipoprotein binding peptidase activity catalytic activity, acting on a protein serine hydrolase activity serine-type peptidase activity hydrolase activity serine-type endopeptidase activity catalytic activity endopeptidase activity enzyme regulator activity molecular function inhibitor activity peptidase regulator activity molecular function regulator activity enzyme inhibitor activity peptidase inhibitor activity endopeptidase regulator activity endopeptidase inhibitor activity fibronectin binding heparin binding glycosaminoglycan binding carbohydrate derivative binding sulfur compound binding	localization transport macromolecule localization lipid localization lipid transport establishment of localization primary metabolic process metabolic process lipid metabolic process proteolysis protein metabolic process macromolecule metabolic process multicellular organismal process system process localization transport macromolecule localization lipid localization lipid transport establishment of localization primary metabolic process metabolic process lipid metabolic process proteolysis protein metabolic process macromolecule metabolic process multicellular organismal process system process circulatory system process blood circulation	extracellular region cellular anatomical entity protein-containing complex plasma lipoprotein particle extracellular space lipoprotein particle protein-lipid complex

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR018056	Kringle, conserved site	Conserved Site
A	IPR018114	Serine proteases, trypsin family, histidine active site	Active Site
A	IPR013806	Kringle-like fold	Homologous Superfamily
A	IPR038178	Kringle superfamily	Homologous Superfamily
A	IPR009003	Peptidase S1, PA clan	Homologous Superfamily
A	IPR050759	Serine proteases and regulators with kringle domains	Family
A	IPR001314	Peptidase S1A, chymotrypsin family	Family
A	IPR033116	Serine proteases, trypsin family, serine active site	Active Site
A	IPR001254	Serine proteases, trypsin domain	Domain
A	IPR043504	Peptidase S1, PA clan, chymotrypsin-like fold	Homologous Superfamily
A	IPR000001	Kringle	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A	Pharos: P08519	atherosclerosis coronary artery disease Thromboembolism cardiovascular disease hypolipoproteinemia metabolic syndrome X peripheral arterial disease abdominal aortic aneurysm arteriosclerosis disorder myocardial infarction psoriasis heart disease inherited lipid metabolism disorder pancreatic ductal adenocarcinoma temporal arteritis atherosclerosis coronary artery disease Thromboembolism cardiovascular disease hypolipoproteinemia metabolic syndrome X peripheral arterial disease abdominal aortic aneurysm arteriosclerosis disorder myocardial infarction psoriasis heart disease inherited lipid metabolism disorder pancreatic ductal adenocarcinoma temporal arteritis aortic stenosis cerebrovascular disorder hepatocellular carcinoma

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.