Annotations: 4CBW

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Actin/HSP70	8082544	4000313	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Actin-like ATPases	8092420	3000092	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Actin-like ATPases	8082545	3000092	SCOP2 (2022-06-29)
B [auth G]	SCOP2 Family	Gelsolin-like	8070773	4001825	SCOP2 (2022-06-29)
B [auth G]	SCOP2 Superfamily	Actin depolymerizing proteins	8070774	3000430	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Actin_1st	e4cbwA2	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Actin_1st	ECOD (1.6)
A	Actin_2nd	e4cbwA1	A: mixed a+b and a/b	X: Ribonuclease H-like	H: Ribonuclease H-like (From Topology)	T: Ribonuclease H-like	F: Actin_2nd	ECOD (1.6)
B [auth G]	Gelsolin_1	e4cbwG1	A: a+b three layers	X: Gelsolin-like (From Topology)	H: Gelsolin-like (From Topology)	T: Gelsolin-like	F: Gelsolin_1	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.420.40	Alpha Beta	2-Layer Sandwich	Nucleotidyltransferase	domain 5	CATH (4.3.0)
A	3.90.640.10	Alpha Beta	Alpha-Beta Complex	Actin	Chain A, domain 4	CATH (4.3.0)
B [auth G]	3.40.20.10	Alpha Beta	3-Layer(aba) Sandwich	Severin	Severin	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
B [auth G]	PF00626	Gelsolin repeat (Gelsolin)	Gelsolin repeat	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	ACTIN, ALPHA SKELETAL MUSCLE, ACTIN	binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding hydrolase activity catalytic activity pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity, acting on acid anhydrides ATP-dependent activity	developmental process mesenchyme migration multicellular organismal process mesenchyme morphogenesis animal organ development mesenchyme development tissue development tissue morphogenesis anatomical structure morphogenesis tissue migration anatomical structure development animal organ morphogenesis myotube cell development skeletal muscle fiber development developmental process mesenchyme migration multicellular organismal process mesenchyme morphogenesis animal organ development mesenchyme development tissue development tissue morphogenesis anatomical structure morphogenesis tissue migration anatomical structure development animal organ morphogenesis myotube cell development skeletal muscle fiber development cellular developmental process skeletal muscle tissue development cell development muscle cell differentiation myotube differentiation striated muscle tissue development muscle structure development skeletal muscle organ development striated muscle cell development muscle cell development cell differentiation cellular process muscle tissue development muscle organ development striated muscle cell differentiation regulation of biosynthetic process regulation of biological process regulation of cellular process biological regulation positive regulation of biological process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of macromolecule biosynthetic process regulation of gene expression positive regulation of metabolic process biosynthetic process positive regulation of gene expression positive regulation of biosynthetic process regulation of macromolecule biosynthetic process metabolic process positive regulation of macromolecule metabolic process macromolecule metabolic process regulation of metabolic process positive regulation of cellular process cellular component assembly involved in morphogenesis skeletal myofibril assembly membraneless organelle assembly cellular component organization cellular component biogenesis cellular anatomical entity morphogenesis cellular component assembly actin filament-based process cellular component organization or biogenesis skeletal muscle thin filament assembly actin cytoskeleton organization actomyosin structure organization organelle assembly actin filament organization organelle organization myofibril assembly anatomical structure formation involved in morphogenesis supramolecular fiber organization cytoskeleton organization	cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium intracellular anatomical structure actin filament bundle intracellular membraneless organelle actin cytoskeleton actomyosin intracellular organelle cytoskeleton organelle membraneless organelle cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium intracellular anatomical structure actin filament bundle intracellular membraneless organelle actin cytoskeleton actomyosin intracellular organelle cytoskeleton organelle membraneless organelle stress fiber contractile actin filament bundle polymeric cytoskeletal fiber actin filament supramolecular fiber supramolecular polymer supramolecular complex cell body striated muscle thin filament myofilament sarcomere contractile muscle fiber cytoplasm myofibril actin-based cell projection filopodium membrane-bounded organelle nucleus intracellular membrane-bounded organelle
B [auth G]	GELSOLIN	cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding myosin II binding myosin binding cation binding ion binding calcium ion binding metal ion binding small molecule binding phosphatidylinositol 3-kinase catalytic subunit binding cytoskeletal protein binding actin binding protein-containing complex binding protein binding binding actin filament binding myosin II binding myosin binding cation binding ion binding calcium ion binding metal ion binding small molecule binding phosphatidylinositol 3-kinase catalytic subunit binding phosphatidylinositol 3-kinase binding kinase binding enzyme binding phosphatidylinositol-4,5-bisphosphate binding anion binding phosphatidylinositol bisphosphate binding phospholipid binding lipid binding phosphatidylinositol phosphate binding phosphatidylinositol binding	membrane organization import into cell transport establishment of localization vesicle-mediated transport cellular component organization localization phagocytosis, engulfment membrane invagination cellular process phagocytosis cellular component organization or biogenesis endocytosis plasma membrane invagination membrane organization import into cell transport establishment of localization vesicle-mediated transport cellular component organization localization phagocytosis, engulfment membrane invagination cellular process phagocytosis cellular component organization or biogenesis endocytosis plasma membrane invagination positive regulation of epithelial cell apoptotic process regulation of biological process regulation of cellular process positive regulation of programmed cell death regulation of epithelial cell apoptotic process positive regulation of keratinocyte apoptotic process regulation of apoptotic process biological regulation positive regulation of biological process regulation of programmed cell death cell death positive regulation of apoptotic process epithelial cell apoptotic process keratinocyte apoptotic process regulation of keratinocyte apoptotic process apoptotic process programmed cell death positive regulation of cellular process developmental process multicellular organism development multicellular organismal process central nervous system development anatomical structure development nervous system development system development protein destabilization regulation of protein stability regulation of biological quality actin filament severing actin filament-based process regulation of localization cellular localization plasma membrane raft distribution regulation of cellular component organization plasma membrane raft polarization plasma membrane organization membrane raft organization endomembrane system organization membrane raft distribution plasma membrane raft localization membrane raft polarization regulation of plasma membrane raft polarization localization within membrane membrane raft localization regulation of plasma membrane organization regulation of cellular localization cellular component disassembly actin polymerization or depolymerization actin cytoskeleton organization protein-containing complex organization actin filament organization protein-containing complex disassembly actin filament depolymerization organelle organization supramolecular fiber organization protein depolymerization cytoskeleton organization protein localization regulation of protein localization protein localization to membrane cellular macromolecule localization macromolecule localization receptor clustering regulation of receptor clustering regulation of protein localization to membrane muscle hypertrophy regulation of muscle adaptation system process positive regulation of cardiac muscle hypertrophy response to stimulus regulation of system process striated muscle hypertrophy regulation of muscle system process muscle system process regulation of cardiac muscle hypertrophy regulation of muscle hypertrophy muscle adaptation regulation of response to stimulus positive regulation of muscle hypertrophy cardiac muscle hypertrophy positive regulation of multicellular organismal process regulation of multicellular organismal process regulation of protein maturation positive regulation of protein maturation positive regulation of protein metabolic process regulation of protein processing in phagocytic vesicle positive regulation of macromolecule biosynthetic process positive regulation of protein processing regulation of primary metabolic process protein maturation positive regulation of metabolic process regulation of proteolysis positive regulation of biosynthetic process proteolysis positive regulation of macromolecule metabolic process positive regulation of protein processing in phagocytic vesicle protein metabolic process regulation of biosynthetic process regulation of protein metabolic process primary metabolic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process protein processing in phagocytic vesicle regulation of gene expression biosynthetic process positive regulation of gene expression regulation of protein processing positive regulation of proteolysis protein processing metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process regulation of metabolic process regulation of cellular component size negative regulation of biological process regulation of protein-containing complex disassembly regulation of actin filament depolymerization cellular component biogenesis actin filament capping cellular component assembly negative regulation of supramolecular fiber organization negative regulation of actin filament polymerization barbed-end actin filament capping negative regulation of cellular component organization regulation of organelle organization negative regulation of protein depolymerization negative regulation of protein-containing complex assembly regulation of protein polymerization regulation of supramolecular fiber organization regulation of cytoskeleton organization regulation of actin filament-based process regulation of protein-containing complex assembly negative regulation of protein-containing complex disassembly negative regulation of cellular process protein-containing complex assembly negative regulation of protein polymerization regulation of actin filament polymerization protein polymerization regulation of actin filament organization actin filament polymerization regulation of protein depolymerization negative regulation of cytoskeleton organization regulation of actin polymerization or depolymerization regulation of cellular component biogenesis negative regulation of organelle organization regulation of actin filament length regulation of actin cytoskeleton organization negative regulation of actin filament depolymerization regulation of anatomical structure size cellular response to stimulus cellular response to metal ion cellular response to chemical stimulus response to metal ion response to chemical cellular response to cadmium ion response to cadmium ion renal system process renal absorption renal protein absorption regulation of establishment of T cell polarity regulation of establishment or maintenance of cell polarity establishment of lymphocyte polarity establishment of T cell polarity cell activation establishment or maintenance of cell polarity lymphocyte activation leukocyte activation establishment of cell polarity regulation of establishment of cell polarity immune system process T cell activation relaxation of cardiac muscle relaxation of muscle positive regulation of organelle organization positive regulation of cellular component organization regulation of actin nucleation positive regulation of cytoskeleton organization positive regulation of supramolecular fiber organization positive regulation of actin nucleation actin nucleation amyloid fibril formation muscle atrophy striated muscle adaptation striated muscle atrophy biological process involved in interspecies interaction between organisms negative regulation of viral life cycle viral life cycle modulation by symbiont of entry into host biological process involved in interaction with host biological process involved in symbiotic interaction regulation of viral entry into host cell regulation of viral life cycle regulation of viral process negative regulation of viral process symbiont entry into host cell viral process symbiont entry into host negative regulation of viral entry into host cell regulation of biological process involved in symbiotic interaction organelle assembly plasma membrane bounded cell projection organization cell projection organization plasma membrane bounded cell projection assembly cilium assembly cilium organization cell projection assembly immune response response to other organism defense response response to type II interferon response to cytokine defense response to symbiont response to external stimulus cellular response to type II interferon response to biotic stimulus response to peptide defense response to other organism response to stress innate immune response cellular response to cytokine stimulus response to external biotic stimulus hepatocyte apoptotic process positive regulation of cell communication positive regulation of signal transduction signaling regulation of signal transduction p38MAPK cascade intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction regulation of signaling positive regulation of MAPK cascade positive regulation of intracellular signal transduction regulation of MAPK cascade positive regulation of p38MAPK cascade regulation of p38MAPK cascade MAPK cascade regulation of cell communication positive regulation of signaling podosome assembly membraneless organelle assembly regulation of podosome assembly regulation of organelle assembly maintenance of location maintenance of protein location maintenance of location in cell maintenance of protein location in cell sequestering of actin monomers heart process cardiac muscle cell contraction actin filament-based movement cardiac muscle contraction muscle contraction striated muscle contraction circulatory system process actin-mediated cell contraction heart contraction blood circulation response to mechanical stimulus response to abiotic stimulus response to muscle stretch	cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium intracellular organelle intracellular anatomical structure podosome cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cytoplasm cell projection cellular anatomical structure cell leading edge plasma membrane bounded cell projection lamellipodium intracellular organelle intracellular anatomical structure podosome cytoskeleton organelle membraneless organelle intracellular membraneless organelle actin cytoskeleton cytoplasm cytosol ruffle perinuclear region of cytoplasm sarcoplasm extracellular region extracellular space myelin sheath cell-cell junction anchoring junction cell junction basal ectoplasmic specialization apical ectoplasmic specialization membrane-bounded organelle intracellular vesicle phagocytic vesicle intracellular membrane-bounded organelle cytoplasmic vesicle vesicle endocytic vesicle cell periphery plasma membrane membrane cell cortex cortical cytoskeleton actin cap cortical actin cytoskeleton protein-containing complex polymeric cytoskeletal fiber glial filament intermediate filament cytoskeleton intermediate filament supramolecular fiber supramolecular polymer supramolecular complex nucleus

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR020902	Actin/actin-like conserved site	Conserved Site
A	IPR004001	Actin, conserved site	Conserved Site
A	IPR043129	ATPase, nucleotide binding domain	Homologous Superfamily
A	IPR004000	Actin family	Family
A	IPR020902	Actin/actin-like conserved site	Conserved Site
A	IPR004001	Actin, conserved site	Conserved Site
A	IPR043129	ATPase, nucleotide binding domain	Homologous Superfamily
A	IPR004000	Actin family	Family
B [auth G]	IPR007123	Gelsolin-like domain	Domain
B [auth G]	IPR029006	ADF-H/Gelsolin-like domain superfamily	Homologous Superfamily
B [auth G]	IPR007122	Villin/Gelsolin	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.