Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AGlyco_hydro_59_Ce4cccA1 A: beta sandwichesX: jelly-rollH: Concanavalin A-likeT: Concanavalin A-like lectins/glucanasesF: Glyco_hydro_59_CECOD (1.6)
AGlyco_hydro_59Me4cccA2 A: beta sandwichesX: Glycosyl hydrolase domain-likeH: Glycosyl hydrolase domain (From Topology)T: Glycosyl hydrolase domainF: Glyco_hydro_59MECOD (1.6)
AGlyco_hydro_59_Ne4cccA3 A: a/b barrelsX: TIM beta/alpha-barrelH: TIM barrels (From Topology)T: TIM barrelsF: Glyco_hydro_59_NECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.20.20.80 Alpha Beta Alpha-Beta Barrel TIM Barrel GlycosidasesCATH (4.3.0)
A3.20.20.70 Alpha Beta Alpha-Beta Barrel TIM Barrel Aldolase class ICATH (4.3.0)
A2.60.120.560 Mainly Beta Sandwich Jelly Rolls Exo-inulinaseCATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
PF17387Glycosyl hydrolase family 59 central domain (Glyco_hydro_59M)Glycosyl hydrolase family 59 central domain- Domain
PF21708Galactocerebrosidase, C-terminal lectin domain (Glyco_hydro_59_C)Galactocerebrosidase, C-terminal lectin domainThis domain is found at the C-terminal end of Galactocerebrosidase from Mus musculus (GALCERase) and similar proteins predominantly found in animals and bacteria. GALCERase hydrolyses the galactose ester bonds of glycolipids such as galactosylceramid ...This domain is found at the C-terminal end of Galactocerebrosidase from Mus musculus (GALCERase) and similar proteins predominantly found in animals and bacteria. GALCERase hydrolyses the galactose ester bonds of glycolipids such as galactosylceramide and galactosylsphingosine. It is responsible for the lysosomal catabolism of galactosylceramide, a major lipid in myelin, kidney and epithelial cells of small intestine and colon. This protein is organised into three domains, all of them contributing residues to the substrate- binding pocket. This entry represents the lectin domain, which is not present in other lysosomal enzymes, is likely to be be involved in processes that are not found in related enzymes. Mutations in this domain lead to Krabbe disease [1].
Domain
PF02057Glycosyl hydrolase family 59 (Glyco_hydro_59)Glycosyl hydrolase family 59- Family

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
GALACTOCEREBROSIDASE