Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
BSCOP2B SuperfamilyTrypsin-like serine proteases 8042154 3000114 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyTrypsin-like serine proteases 8042154 3000114 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyTrypsin-like serine proteases 8042154 3000114 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyTrypsin-like serine proteases 8042154 3000114 SCOP2B (2022-06-29)

Domain Annotation: CATH CATH Database Homepage

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
B, D, F, H
PF00089Trypsin (Trypsin)Trypsin- Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, C, E, G
THROMBIN, LIGHT CHAIN
B, D, F, H
THROMBIN, HEAVY CHAIN
I [auth P],
J [auth Q],
K [auth R],
L [auth S]
PLATELET GLYCOPROTEIN IB ALPHA CHAIN, RESIDUES 287-300

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, C, E, G
IPR018992Thrombin light chainDomain
A, C, E, G
IPR037111Thrombin light chain domain superfamilyHomologous Superfamily
A, C, E, G
IPR003966Prothrombin/thrombinFamily
A, C, E, G
IPR018114Serine proteases, trypsin family, histidine active siteActive Site
A, C, E, G
IPR009003Peptidase S1, PA clanHomologous Superfamily
A, C, E, G
IPR033116Serine proteases, trypsin family, serine active siteActive Site
A, C, E, G
IPR001254Serine proteases, trypsin domainDomain
A, C, E, G
IPR035972Gamma-carboxyglutamic acid-rich (GLA) domain superfamilyHomologous Superfamily
A, C, E, G
IPR000001KringleDomain
A, C, E, G
IPR000294Gamma-carboxyglutamic acid-rich (GLA) domainDomain
A, C, E, G
IPR051659Serine Protease S1 Domain-Containing ProteinFamily
A, C, E, G
IPR018056Kringle, conserved siteConserved Site
A, C, E, G
IPR013806Kringle-like foldHomologous Superfamily
A, C, E, G
IPR038178Kringle superfamilyHomologous Superfamily
A, C, E, G
IPR001314Peptidase S1A, chymotrypsin familyFamily
A, C, E, G
IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily
B, D, F, H
IPR018992Thrombin light chainDomain
B, D, F, H
IPR037111Thrombin light chain domain superfamilyHomologous Superfamily
B, D, F, H
IPR003966Prothrombin/thrombinFamily
B, D, F, H
IPR018114Serine proteases, trypsin family, histidine active siteActive Site
B, D, F, H
IPR009003Peptidase S1, PA clanHomologous Superfamily
B, D, F, H
IPR033116Serine proteases, trypsin family, serine active siteActive Site
B, D, F, H
IPR001254Serine proteases, trypsin domainDomain
B, D, F, H
IPR035972Gamma-carboxyglutamic acid-rich (GLA) domain superfamilyHomologous Superfamily
B, D, F, H
IPR000001KringleDomain
B, D, F, H
IPR000294Gamma-carboxyglutamic acid-rich (GLA) domainDomain
B, D, F, H
IPR051659Serine Protease S1 Domain-Containing ProteinFamily
B, D, F, H
IPR018056Kringle, conserved siteConserved Site
B, D, F, H
IPR013806Kringle-like foldHomologous Superfamily
B, D, F, H
IPR038178Kringle superfamilyHomologous Superfamily
B, D, F, H
IPR001314Peptidase S1A, chymotrypsin familyFamily
B, D, F, H
IPR043504Peptidase S1, PA clan, chymotrypsin-like foldHomologous Superfamily
I [auth P],
J [auth Q],
K [auth R],
L [auth S]
IPR000372Leucine-rich repeat N-terminal domainDomain
I [auth P],
J [auth Q],
K [auth R],
L [auth S]
IPR003591Leucine-rich repeat, typical subtypeRepeat
I [auth P],
J [auth Q],
K [auth R],
L [auth S]
IPR051432Voltage and calcium-activated potassium channel auxiliary proteinFamily
I [auth P],
J [auth Q],
K [auth R],
L [auth S]
IPR001611Leucine-rich repeatRepeat
I [auth P],
J [auth Q],
K [auth R],
L [auth S]
IPR032675Leucine-rich repeat domain superfamilyHomologous Superfamily
I [auth P],
J [auth Q],
K [auth R],
L [auth S]
IPR000483Cysteine-rich flanking region, C-terminalDomain

Pharos: Disease Associations Pharos Homepage Annotation

ChainsDrug Target  Associated Disease
A, C, E, G
PharosP00734
B, D, F, H
PharosP00734
I [auth P],
J [auth Q],
K [auth R],
L [auth S]
PharosP07359

Protein Modification Annotation

Modified Residue(s)
ChainResidue(s)Description
I [auth P],
J [auth Q],
K [auth R],
L [auth S]
PTR Parent Component: TYR

RESIDAA0039

PSI-MOD :  O4'-phospho-L-tyrosine MOD:00048