Annotations: 4ESP

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4espa_	Alpha and beta proteins (a+b)	Profilin-like	Profilin (actin-binding protein)	Profilin (actin-binding protein)	automated matches	goober,ground-nut (Arachis hypogaea ) [TaxId: 3818 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Profilin (actin-binding protein)	8073260	4001840	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Profilin (actin-binding protein)	8073261	3000452	SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Profilin	e4espA1	A: a+b three layers	X: Profilin-like	H: profilin-like (From Topology)	T: profilin-like	F: Profilin	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.450.30	Alpha Beta	2-Layer Sandwich	Beta-Lactamase	Dynein light chain 2a, cytoplasmic	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A	PF00235	Profilin (Profilin)	Profilin	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A	Profilin	cytoskeletal protein binding actin monomer binding actin binding protein binding binding	protein localization regulation of cellular process regulation of cellular component size negative regulation of biological process cellular component biogenesis localization cellular component assembly cellular macromolecule localization actin filament-based process regulation of biological quality negative regulation of supramolecular fiber organization negative regulation of actin filament polymerization regulation of biological process negative regulation of cellular component organization protein localization regulation of cellular process regulation of cellular component size negative regulation of biological process cellular component biogenesis localization cellular component assembly cellular macromolecule localization actin filament-based process regulation of biological quality negative regulation of supramolecular fiber organization negative regulation of actin filament polymerization regulation of biological process negative regulation of cellular component organization actin filament organization regulation of organelle organization maintenance of location negative regulation of protein-containing complex assembly regulation of protein polymerization regulation of supramolecular fiber organization supramolecular fiber organization maintenance of protein location regulation of cytoskeleton organization cellular localization regulation of cellular component organization regulation of actin filament-based process maintenance of location in cell cellular component organization regulation of protein-containing complex assembly maintenance of protein location in cell protein-containing complex assembly negative regulation of cellular process negative regulation of protein polymerization regulation of actin filament polymerization cellular component organization or biogenesis protein polymerization actin polymerization or depolymerization regulation of actin filament organization actin filament polymerization actin cytoskeleton organization protein-containing complex organization negative regulation of cytoskeleton organization biological regulation regulation of actin polymerization or depolymerization regulation of cellular component biogenesis sequestering of actin monomers organelle organization negative regulation of organelle organization regulation of actin filament length macromolecule localization regulation of actin cytoskeleton organization cellular process cytoskeleton organization regulation of anatomical structure size	cell periphery cell cortex cellular anatomical structure intracellular anatomical structure cytoplasm intracellular organelle cytoskeleton organelle membraneless organelle intracellular membraneless organelle

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A	IPR036140	Profilin superfamily	Homologous Superfamily
A	IPR027310	Profilin conserved site	Conserved Site
A	IPR048278	Profilin	Family
A	IPR005455	Profilin, eukaryotic type	Family

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.