Annotations: 4F92

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A [auth B]	SCOP2B Superfamily	E set domains	8055093	3000070	SCOP2B (2022-06-29)
A [auth B]	SCOP2B Superfamily	Brl domain-like	8036193	3000115	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A [auth B]	Sec63_3rd	e4f92B50	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Sec63_3rd	ECOD (1.6)
A [auth B]	KOG0952	e4f92B48	A: alpha arrays	X: HTH	H: HTH	T: winged	F: KOG0952	ECOD (1.6)
A [auth B]	Sec63_2nd_1	e4f92B54	A: alpha arrays	X: HhH/H2TH	H: SAM-like subdomain in Sec63-like proteins (From Topology)	T: SAM-like subdomain in Sec63-like proteins	F: Sec63_2nd_1	ECOD (1.6)
A [auth B]	Sec63_2nd	e4f92B47	A: alpha arrays	X: HhH/H2TH	H: SAM-like subdomain in Sec63-like proteins (From Topology)	T: SAM-like subdomain in Sec63-like proteins	F: Sec63_2nd	ECOD (1.6)
A [auth B]	Sec63_1st	e4f92B52	A: alpha arrays	X: Sec63 N-terminal subdomain-like (From Topology)	H: Sec63 N-terminal subdomain-like (From Topology)	T: Sec63 N-terminal subdomain-like	F: Sec63_1st	ECOD (1.6)
A [auth B]	DEAD_1	e4f92B57	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: DEAD_1	ECOD (1.6)
A [auth B]	Helicase_C_5	e4f92B58	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: Helicase_C_5	ECOD (1.6)
A [auth B]	DEAD_1,KOG0951_2nd	e4f92B53	A: a/b three-layered sandwiches	X: P-loop domains-like	H: P-loop domains-related	T: P-loop containing nucleoside triphosphate hydrolases	F: DEAD_1,KOG0951_2nd	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A [auth B]	3.40.50.300	Alpha Beta	3-Layer(aba) Sandwich	Rossmann fold	P-loop containing nucleotide triphosphate hydrolases	CATH (4.3.0)
A [auth B]	1.10.10.10	Mainly Alpha	Orthogonal Bundle	Arc Repressor Mutant, subunit A	Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain	CATH (4.3.0)
A [auth B]	1.10.3380.10	Mainly Alpha	Orthogonal Bundle	Sec63 N-terminal domain-like fold	Sec63 N-terminal domain-like domain	CATH (4.3.0)
A [auth B]	1.10.150.20	Mainly Alpha	Orthogonal Bundle	DNA polymerase	domain 1	CATH (4.3.0)
A [auth B]	2.60.40.150	Mainly Beta	Sandwich	Immunoglobulin-like	C2 domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A [auth B]	PF02889	Sec63 Brl domain (Sec63)	Sec63 Brl domain	-	Family
A [auth B]	PF00270	DEAD/DEAH box helicase (DEAD)	DEAD/DEAH box helicase	Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome ...	Members of this family include the DEAD and DEAH box helicases. Helicases are involved in unwinding nucleic acids. The DEAD box helicases are involved in various aspects of RNA metabolism, including nuclear transcription, pre mRNA splicing, ribosome biogenesis, nucleocytoplasmic transport, translation, RNA decay and organellar gene expression.	Domain
A [auth B]	PF00271	Helicase conserved C-terminal domain (Helicase_C)	Helicase conserved C-terminal domain	The Prosite family is restricted to DEAD/H helicases, whereas this domain family is found in a wide variety of helicases and helicase related proteins. It may be that this is not an autonomously folding unit, but an integral part of the helicase.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A [auth B]	U5 small nuclear ribonucleoprotein 200 kDa helicase	catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity RNA binding binding organic cyclic compound binding nucleic acid binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding catalytic activity, acting on a nucleic acid helicase activity catalytic activity ATP-dependent activity RNA binding binding organic cyclic compound binding nucleic acid binding adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding pyrophosphatase activity ATP hydrolysis activity ribonucleoside triphosphate phosphatase activity hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides hydrolase activity hydrolase activity, acting on acid anhydrides catalytic activity, acting on RNA RNA helicase activity ATP-dependent activity, acting on RNA identical protein binding protein binding	developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation ribonucleoprotein complex biogenesis RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process developmental process multicellular organismal process cellular developmental process ossification cell differentiation cellular process osteoblast differentiation ribonucleoprotein complex biogenesis RNA metabolic process mRNA processing protein-RNA complex assembly cellular component organization cellular component biogenesis nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process protein-RNA complex organization cellular component assembly protein-containing complex assembly cellular component organization or biogenesis RNA processing RNA splicing spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) protein-containing complex organization spliceosomal conformational changes to generate catalytic conformation primary metabolic process gene expression nucleobase-containing compound biosynthetic process mRNA metabolic process macromolecule biosynthetic process nucleic acid metabolic process biosynthetic process RNA splicing, via transesterification reactions mRNA splicing, via spliceosome metabolic process RNA splicing, via transesterification reactions with bulged adenosine as nucleophile macromolecule metabolic process spliceosomal complex assembly mRNA cis splicing, via spliceosome cis assembly of pre-catalytic spliceosome	cellular anatomical structure membrane membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex U2-type catalytic step 1 spliceosome intracellular membrane-bounded organelle intracellular organelle spliceosomal complex organelle cellular anatomical structure membrane membrane-bounded organelle U2-type spliceosomal complex protein-containing complex intracellular anatomical structure catalytic complex nucleus nuclear protein-containing complex U2-type catalytic step 1 spliceosome intracellular membrane-bounded organelle intracellular organelle spliceosomal complex organelle ribonucleoprotein complex catalytic step 1 spliceosome catalytic step 2 spliceosome spliceosomal snRNP complex Sm-like protein family complex U4/U6 x U5 tri-snRNP complex spliceosomal tri-snRNP complex small nuclear ribonucleoprotein complex membrane-enclosed lumen intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen U2-type precatalytic spliceosome precatalytic spliceosome U5 snRNP

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A [auth B]	IPR048863	Pre-mRNA-splicing helicase BRR2-like, plug domain	Domain
A [auth B]	IPR041094	Brr2, N-terminal helicase PWI domain	Domain
A [auth B]	IPR004179	Sec63 domain	Domain
A [auth B]	IPR014756	Immunoglobulin E-set	Homologous Superfamily
A [auth B]	IPR011545	DEAD/DEAH box helicase domain	Domain
A [auth B]	IPR027417	P-loop containing nucleoside triphosphate hydrolase	Homologous Superfamily
A [auth B]	IPR050474	Helicase Hel308/SKI2-like	Family
A [auth B]	IPR001650	Helicase, C-terminal domain-like	Domain
A [auth B]	IPR036388	Winged helix-like DNA-binding domain superfamily	Homologous Superfamily
A [auth B]	IPR014001	Helicase superfamily 1/2, ATP-binding domain	Domain
A [auth B]	IPR036390	Winged helix DNA-binding domain superfamily	Homologous Superfamily
A [auth B]	IPR035892	C2 domain superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A [auth B]	Pharos: O75643	retinitis pigmentosa retinitis pigmentosa 33 acute myeloid leukemia cone-rod dystrophy large cell medulloblastoma malignant pancreatic neoplasm osteosarcoma psoriasis astrocytic tumor dermatomyositis lung cancer medulloblastoma ovarian cancer retinal degeneration colorectal cancer retinitis pigmentosa retinitis pigmentosa 33 acute myeloid leukemia cone-rod dystrophy large cell medulloblastoma malignant pancreatic neoplasm osteosarcoma psoriasis astrocytic tumor dermatomyositis lung cancer medulloblastoma ovarian cancer retinal degeneration colorectal cancer diabetes mellitus malignant ependymoma oligodendroglioma primitive neuroectodermal tumor

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.