Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad4foxa_ Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase automated matches (Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ], SCOPe (2.08)
Bd4foxb_ Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase automated matches (Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ], SCOPe (2.08)
Cd4foxc_ Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase automated matches (Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ], SCOPe (2.08)
Dd4foxd_ Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase automated matches (Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ], SCOPe (2.08)
Ed4foxe_ Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase automated matches (Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ], SCOPe (2.08)
Fd4foxf_ Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase automated matches (Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ], SCOPe (2.08)
Gd4foxg_ Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase automated matches (Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ], SCOPe (2.08)
Hd4foxh_ Alpha and beta proteins (a+b) Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase Thymidylate synthase/dCMP hydroxymethylase automated matches (Mycobacterium tuberculosis H37Rv ) [TaxId: 83332 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
ASCOP2B SuperfamilyThymidylate synthase/dCMP hydroxymethylase 8069063 3000544 SCOP2B (2022-06-29)
BSCOP2B SuperfamilyThymidylate synthase/dCMP hydroxymethylase 8069063 3000544 SCOP2B (2022-06-29)
CSCOP2B SuperfamilyThymidylate synthase/dCMP hydroxymethylase 8069063 3000544 SCOP2B (2022-06-29)
DSCOP2B SuperfamilyThymidylate synthase/dCMP hydroxymethylase 8069063 3000544 SCOP2B (2022-06-29)
ESCOP2B SuperfamilyThymidylate synthase/dCMP hydroxymethylase 8069063 3000544 SCOP2B (2022-06-29)
FSCOP2B SuperfamilyThymidylate synthase/dCMP hydroxymethylase 8069063 3000544 SCOP2B (2022-06-29)
GSCOP2B SuperfamilyThymidylate synthase/dCMP hydroxymethylase 8069063 3000544 SCOP2B (2022-06-29)
HSCOP2B SuperfamilyThymidylate synthase/dCMP hydroxymethylase 8069063 3000544 SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AThymidylat_synte4foxA1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
BThymidylat_synte4foxB1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
CThymidylat_synte4foxC1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
DThymidylat_synte4foxD1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
EThymidylat_synte4foxE1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
FThymidylat_synte4foxF1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
GThymidylat_synte4foxG1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)
HThymidylat_synte4foxH1 A: a+b two layersX: Thymidylate synthase/dCMP hydroxymethylase (From Topology)H: Thymidylate synthase/dCMP hydroxymethylase (From Topology)T: Thymidylate synthase/dCMP hydroxymethylaseF: Thymidylat_syntECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.30.572.10 Alpha Beta 2-Layer Sandwich Thymidylate Synthase Chain ACATH (4.3.0)
B3.30.572.10 Alpha Beta 2-Layer Sandwich Thymidylate Synthase Chain ACATH (4.3.0)
C3.30.572.10 Alpha Beta 2-Layer Sandwich Thymidylate Synthase Chain ACATH (4.3.0)
D3.30.572.10 Alpha Beta 2-Layer Sandwich Thymidylate Synthase Chain ACATH (4.3.0)
E3.30.572.10 Alpha Beta 2-Layer Sandwich Thymidylate Synthase Chain ACATH (4.3.0)
F3.30.572.10 Alpha Beta 2-Layer Sandwich Thymidylate Synthase Chain ACATH (4.3.0)
G3.30.572.10 Alpha Beta 2-Layer Sandwich Thymidylate Synthase Chain ACATH (4.3.0)
H3.30.572.10 Alpha Beta 2-Layer Sandwich Thymidylate Synthase Chain ACATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

ChainsAccessionNameDescriptionCommentsSource
A, B, C, D, E
PF00303Thymidylate synthase (Thymidylat_synt)Thymidylate synthaseThis is a family of proteins that are flavin-dependent thymidylate synthases.Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

ChainsPolymerMolecular FunctionBiological ProcessCellular Component
A, B, C, D, E
Thymidylate synthase

InterPro: Protein Family Classification InterPro Database Homepage

ChainsAccessionNameType
A, B, C, D, E
IPR045097Thymidylate synthase/dCMP hydroxymethylaseFamily
A, B, C, D, E
IPR020940Thymidylate synthase, active siteActive Site
A, B, C, D, E
IPR036926Thymidylate synthase/dCMP hydroxymethylase superfamilyHomologous Superfamily
A, B, C, D, E
IPR023451Thymidylate synthase/dCMP hydroxymethylase domainDomain
A, B, C, D, E
IPR000398Thymidylate synthaseFamily