4G8A
Crystal structure of human TLR4 polymorphic variant D299G and T399I in complex with MD-2 and LPS
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
C | E1_DerP2_DerF2 | e4g8aC1 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: E1_DerP2_DerF2 | ECOD (1.6) |
D | E1_DerP2_DerF2 | e4g8aD2 | A: beta sandwiches | X: Immunoglobulin-like beta-sandwich | H: Immunoglobulin-related | T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like | F: E1_DerP2_DerF2 | ECOD (1.6) |
A | LRR_8_3 | e4g8aA3 | A: beta duplicates or obligate multimers | X: Single-stranded right-handed beta-helix | H: Leucine-rich repeats (From Topology) | T: Leucine-rich repeats | F: LRR_8_3 | ECOD (1.6) |
A | LRR_8_1 | e4g8aA4 | A: beta duplicates or obligate multimers | X: Single-stranded right-handed beta-helix | H: Leucine-rich repeats (From Topology) | T: Leucine-rich repeats | F: LRR_8_1 | ECOD (1.6) |
B | LRR_8_3 | e4g8aB3 | A: beta duplicates or obligate multimers | X: Single-stranded right-handed beta-helix | H: Leucine-rich repeats (From Topology) | T: Leucine-rich repeats | F: LRR_8_3 | ECOD (1.6) |
B | LRR_8_1 | e4g8aB4 | A: beta duplicates or obligate multimers | X: Single-stranded right-handed beta-helix | H: Leucine-rich repeats (From Topology) | T: Leucine-rich repeats | F: LRR_8_1 | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
C | 2.60.40.770 | Mainly Beta | Sandwich | Immunoglobulin-like | CATH (4.3.0) | |
D | 2.60.40.770 | Mainly Beta | Sandwich | Immunoglobulin-like | CATH (4.3.0) | |
A | 3.80.10.10 | Alpha Beta | Alpha-Beta Horseshoe | Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) | Ribonuclease Inhibitor | CATH (4.3.0) |
B | 3.80.10.10 | Alpha Beta | Alpha-Beta Horseshoe | Leucine-rich repeat, LRR (right-handed beta-alpha superhelix) | Ribonuclease Inhibitor | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF02221 | ML domain (E1_DerP2_DerF2) | ML domain | ML domain - MD-2-related lipid recognition domain. This family consists of proteins from plants, animals and fungi, including dust mite allergen Der P 2 (Swiss:P49278). It has been implicate in lipid recognition, particularly in the recognition of pa ... | Domain | |
PF13855 | Leucine rich repeat (LRR_8) | Leucine rich repeat | - | Repeat | |
PF13516 | Leucine Rich repeat (LRR_6) | Leucine Rich repeat | - | Repeat | |
PF12799 | Leucine Rich repeats (2 copies) (LRR_4) | Leucine Rich repeats (2 copies) | - | Repeat |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR003172 | MD-2-related lipid-recognition domain | Domain | |
IPR014756 | Immunoglobulin E-set | Homologous Superfamily | |
IPR039217 | Lymphocyte antigen 96 | Family | |
IPR035897 | Toll/interleukin-1 receptor homology (TIR) domain superfamily | Homologous Superfamily | |
IPR000483 | Cysteine-rich flanking region, C-terminal | Domain | |
IPR000157 | Toll/interleukin-1 receptor homology (TIR) domain | Domain | |
IPR025875 | Leucine rich repeat 4 | Repeat | |
IPR032675 | Leucine-rich repeat domain superfamily | Homologous Superfamily | |
IPR001611 | Leucine-rich repeat | Repeat | |
IPR017241 | Toll-like receptor | Family | |
IPR003591 | Leucine-rich repeat, typical subtype | Repeat |
Pharos: Disease Associations Pharos Homepage Annotation
Membrane Protein Annotation: OPM OPM Database Homepage
Chains | External Link | Type | Class | Superfamily | Family |
---|---|---|---|---|---|
OPM | Monotopic/peripheral | All beta monotopic/peripheral | Immunoglobulin-like superfamily (E set) | ML domain |