4GD7
Wild-Type Human Thymidylate Synthase with bound Purpurogallin
External Resource: Annotation
- Domain Annotation: SCOP/SCOPe Classification
- Domain Annotation: SCOP2 Classification
- Domain Annotation: ECOD Classification
- Domain Annotation: CATH
- Protein Family Annotation
- Gene Ontology: Gene Product Annotation
- InterPro: Protein Family Classification
- Pharos: Disease Associations
- Protein Modification Annotation
Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage
Chains | Domain Info | Class | Fold | Superfamily | Family | Domain | Species | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | d4gd7a_ | Alpha and beta proteins (a+b) | Thymidylate synthase/dCMP hydroxymethylase | Thymidylate synthase/dCMP hydroxymethylase | Thymidylate synthase/dCMP hydroxymethylase | Thymidylate synthase | human (Homo sapiens ) [TaxId: 9606 ], | SCOPe (2.08) |
Domain Annotation: SCOP2 Classification SCOP2 Database Homepage
Domain Annotation: ECOD Classification ECOD Database Homepage
Chains | Family Name | Domain Identifier | Architecture | Possible Homology | Homology | Topology | Family | Provenance Source (Version) |
---|---|---|---|---|---|---|---|---|
A | Thymidylat_synt | e4gd7A1 | A: a+b two layers | X: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | H: Thymidylate synthase/dCMP hydroxymethylase (From Topology) | T: Thymidylate synthase/dCMP hydroxymethylase | F: Thymidylat_synt | ECOD (1.6) |
Domain Annotation: CATH CATH Database Homepage
Chain | Domain | Class | Architecture | Topology | Homology | Provenance Source (Version) |
---|---|---|---|---|---|---|
A | 3.30.572.10 | Alpha Beta | 2-Layer Sandwich | Thymidylate Synthase | Chain A | CATH (4.3.0) |
Protein Family Annotation Pfam Database Homepage
Chains | Accession | Name | Description | Comments | Source |
---|---|---|---|---|---|
PF00303 | Thymidylate synthase (Thymidylat_synt) | Thymidylate synthase | This is a family of proteins that are flavin-dependent thymidylate synthases. | Domain |
Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage
InterPro: Protein Family Classification InterPro Database Homepage
Chains | Accession | Name | Type |
---|---|---|---|
IPR036926 | Thymidylate synthase/dCMP hydroxymethylase superfamily | Homologous Superfamily | |
IPR000398 | Thymidylate synthase | Family | |
IPR020940 | Thymidylate synthase, active site | Active Site | |
IPR023451 | Thymidylate synthase/dCMP hydroxymethylase domain | Domain | |
IPR045097 | Thymidylate synthase/dCMP hydroxymethylase | Family |