4GJQ

Crystal structure of human GLTP bound with 12:0 monosulfatide (orthorhombic form;two subunits in asymmetric unit)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
A	d4gjqa_	All alpha proteins	Glycolipid transfer protein, GLTP	Glycolipid transfer protein, GLTP	Glycolipid transfer protein, GLTP	Glycolipid transfer protein, GLTP	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)
B	d4gjqb_	All alpha proteins	Glycolipid transfer protein, GLTP	Glycolipid transfer protein, GLTP	Glycolipid transfer protein, GLTP	Glycolipid transfer protein, GLTP	human (Homo sapiens ) [TaxId: 9606 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2B Superfamily	Glycolipid transfer protein, GLTP	8040219	3001991	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Glycolipid transfer protein, GLTP	8040219	3001991	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	GLTP	e4gjqA1	A: alpha arrays	X: Glycolipid transfer protein, GLTP (From Topology)	H: Glycolipid transfer protein, GLTP (From Topology)	T: Glycolipid transfer protein, GLTP	F: GLTP	ECOD (1.6)
B	GLTP	e4gjqB1	A: alpha arrays	X: Glycolipid transfer protein, GLTP (From Topology)	H: Glycolipid transfer protein, GLTP (From Topology)	T: Glycolipid transfer protein, GLTP	F: GLTP	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	1.10.3520.10	Mainly Alpha	Orthogonal Bundle	Glycolipid transfer protein, GLTP	Glycolipid transfer protein	CATH (4.3.0)
B	1.10.3520.10	Mainly Alpha	Orthogonal Bundle	Glycolipid transfer protein, GLTP	Glycolipid transfer protein	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B	PF08718	Glycolipid transfer protein (GLTP) (GLTP)	Glycolipid transfer protein (GLTP)	GLTP is a cytosolic protein that catalyses the intermembrane transfer of glycolipids [1][2].	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B	Glycolipid transfer protein	lipid transporter activity lipid transfer activity transporter activity glycolipid transfer activity phospholipid transfer activity sphingolipid transfer activity sphingolipid transporter activity ceramide transfer activity ceramide 1-phosphate transfer activity phospholipid transporter activity binding lipid binding amide binding ceramide binding lipid transporter activity lipid transfer activity transporter activity glycolipid transfer activity phospholipid transfer activity sphingolipid transfer activity sphingolipid transporter activity ceramide transfer activity ceramide 1-phosphate transfer activity phospholipid transporter activity binding lipid binding amide binding ceramide binding ion binding sphingolipid binding anion binding phospholipid binding ceramide 1-phosphate binding small molecule binding glycolipid binding carbohydrate derivative binding identical protein binding protein binding	response to immobilization stress response to stimulus response to stress localization nitrogen compound transport ceramide transport transport amide transport macromolecule localization lipid localization lipid transport establishment of localization membrane organization intermembrane lipid transfer response to immobilization stress response to stimulus response to stress localization nitrogen compound transport ceramide transport transport amide transport macromolecule localization lipid localization lipid transport establishment of localization membrane organization intermembrane lipid transfer cellular component organization cellular process cellular component organization or biogenesis	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B	IPR036497	Glycolipid transfer protein superfamily	Homologous Superfamily
A, B	IPR014830	Glycolipid transfer protein domain	Domain

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, B	Pharos: Q9NZD2	diabetes mellitus psoriasis interstitial cystitis spina bifida medulloblastoma ulcerative colitis

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.