4GKI

Crystal structure of the aminoglycoside phosphotransferase APH(3')-Ia, with substrate kanamycin and small molecule inhibitor 1-NM-PP1

External Resource: Annotation


Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

ChainsDomain InfoClassFoldSuperfamilyFamilyDomainSpeciesProvenance Source (Version)
Ad4gkia1 Alpha and beta proteins (a+b) Protein kinase-like (PK-like) Protein kinase-like (PK-like) automated matches automated matches (Acinetobacter baumannii AYE ) [TaxId: 509173 ], SCOPe (2.08)
Ad4gkia2 Artifacts Tags Tags Tags N-terminal Tags (Acinetobacter baumannii AYE ) [TaxId: 509173 ], SCOPe (2.08)
Bd4gkib_ Alpha and beta proteins (a+b) Protein kinase-like (PK-like) Protein kinase-like (PK-like) automated matches automated matches (Acinetobacter baumannii AYE ) [TaxId: 509173 ], SCOPe (2.08)
Cd4gkic1 Alpha and beta proteins (a+b) Protein kinase-like (PK-like) Protein kinase-like (PK-like) automated matches automated matches (Acinetobacter baumannii AYE ) [TaxId: 509173 ], SCOPe (2.08)
Cd4gkic2 Artifacts Tags Tags Tags N-terminal Tags (Acinetobacter baumannii AYE ) [TaxId: 509173 ], SCOPe (2.08)
Dd4gkid_ Alpha and beta proteins (a+b) Protein kinase-like (PK-like) Protein kinase-like (PK-like) automated matches automated matches (Acinetobacter baumannii AYE ) [TaxId: 509173 ], SCOPe (2.08)
Ed4gkie_ Alpha and beta proteins (a+b) Protein kinase-like (PK-like) Protein kinase-like (PK-like) automated matches automated matches (Acinetobacter baumannii AYE ) [TaxId: 509173 ], SCOPe (2.08)
Fd4gkif_ Alpha and beta proteins (a+b) Protein kinase-like (PK-like) Protein kinase-like (PK-like) automated matches automated matches (Acinetobacter baumannii AYE ) [TaxId: 509173 ], SCOPe (2.08)
Gd4gkig1 Alpha and beta proteins (a+b) Protein kinase-like (PK-like) Protein kinase-like (PK-like) automated matches automated matches (Acinetobacter baumannii AYE ) [TaxId: 509173 ], SCOPe (2.08)
Gd4gkig2 Artifacts Tags Tags Tags N-terminal Tags (Acinetobacter baumannii AYE ) [TaxId: 509173 ], SCOPe (2.08)
Hd4gkih_ Alpha and beta proteins (a+b) Protein kinase-like (PK-like) Protein kinase-like (PK-like) automated matches automated matches (Acinetobacter baumannii AYE ) [TaxId: 509173 ], SCOPe (2.08)
Jd4gkij1 Alpha and beta proteins (a+b) Protein kinase-like (PK-like) Protein kinase-like (PK-like) automated matches automated matches (Acinetobacter baumannii AYE ) [TaxId: 509173 ], SCOPe (2.08)
Jd4gkij2 Artifacts Tags Tags Tags N-terminal Tags (Acinetobacter baumannii AYE ) [TaxId: 509173 ], SCOPe (2.08)
Ld4gkil_ Alpha and beta proteins (a+b) Protein kinase-like (PK-like) Protein kinase-like (PK-like) automated matches automated matches (Acinetobacter baumannii AYE ) [TaxId: 509173 ], SCOPe (2.08)
Id4gkii_ Alpha and beta proteins (a+b) Protein kinase-like (PK-like) Protein kinase-like (PK-like) automated matches automated matches (Acinetobacter baumannii AYE ) [TaxId: 509173 ], SCOPe (2.08)
Kd4gkik_ Alpha and beta proteins (a+b) Protein kinase-like (PK-like) Protein kinase-like (PK-like) automated matches automated matches (Acinetobacter baumannii AYE ) [TaxId: 509173 ], SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

ChainsTypeFamily Name Domain Identifier Family IdentifierProvenance Source (Version)
BSCOP2 FamilyAPH phosphotransferases 8069296 4003646 SCOP2 (2022-06-29)
BSCOP2 SuperfamilyProtein kinase-like (PK-like) 8069297 3000066 SCOP2 (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

ChainsFamily NameDomain Identifier ArchitecturePossible HomologyHomologyTopologyFamilyProvenance Source (Version)
AFructosamin_kine4gkiA1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Fructosamin_kinECOD (1.6)
BFructosamin_kine4gkiB1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Fructosamin_kinECOD (1.6)
CFructosamin_kine4gkiC1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Fructosamin_kinECOD (1.6)
DFructosamin_kine4gkiD1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Fructosamin_kinECOD (1.6)
EFructosamin_kine4gkiE1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Fructosamin_kinECOD (1.6)
FFructosamin_kine4gkiF1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Fructosamin_kinECOD (1.6)
GFructosamin_kine4gkiG1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Fructosamin_kinECOD (1.6)
HFructosamin_kine4gkiH1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Fructosamin_kinECOD (1.6)
JFructosamin_kine4gkiJ1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Fructosamin_kinECOD (1.6)
LFructosamin_kine4gkiL1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Fructosamin_kinECOD (1.6)
IFructosamin_kine4gkiI1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Fructosamin_kinECOD (1.6)
KFructosamin_kine4gkiK1 A: a+b complex topologyX: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)H: Protein kinase/SAICAR synthase/ATP-graspT: Protein kinaseF: Fructosamin_kinECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

ChainDomainClassArchitectureTopologyHomologyProvenance Source (Version)
A3.30.200.20 Alpha Beta 2-Layer Sandwich Phosphorylase Kinase domain 1CATH (4.3.0)
A3.90.1200.10 Alpha Beta Alpha-Beta Complex Aminoglycoside 3'-phosphotransferase Chain: A, domain 2CATH (4.3.0)
B3.30.200.20 Alpha Beta 2-Layer Sandwich Phosphorylase Kinase domain 1CATH (4.3.0)
B3.90.1200.10 Alpha Beta Alpha-Beta Complex Aminoglycoside 3'-phosphotransferase Chain: A, domain 2CATH (4.3.0)
C3.30.200.20 Alpha Beta 2-Layer Sandwich Phosphorylase Kinase domain 1CATH (4.3.0)
C3.90.1200.10 Alpha Beta Alpha-Beta Complex Aminoglycoside 3'-phosphotransferase Chain: A, domain 2CATH (4.3.0)
D3.30.200.20 Alpha Beta 2-Layer Sandwich Phosphorylase Kinase domain 1CATH (4.3.0)
D3.90.1200.10 Alpha Beta Alpha-Beta Complex Aminoglycoside 3'-phosphotransferase Chain: A, domain 2CATH (4.3.0)
E3.30.200.20 Alpha Beta 2-Layer Sandwich Phosphorylase Kinase domain 1CATH (4.3.0)
E3.90.1200.10 Alpha Beta Alpha-Beta Complex Aminoglycoside 3'-phosphotransferase Chain: A, domain 2CATH (4.3.0)
F3.30.200.20 Alpha Beta 2-Layer Sandwich Phosphorylase Kinase domain 1CATH (4.3.0)
F3.90.1200.10 Alpha Beta Alpha-Beta Complex Aminoglycoside 3'-phosphotransferase Chain: A, domain 2CATH (4.3.0)
G3.30.200.20 Alpha Beta 2-Layer Sandwich Phosphorylase Kinase domain 1CATH (4.3.0)
G3.90.1200.10 Alpha Beta Alpha-Beta Complex Aminoglycoside 3'-phosphotransferase Chain: A, domain 2CATH (4.3.0)
H3.30.200.20 Alpha Beta 2-Layer Sandwich Phosphorylase Kinase domain 1CATH (4.3.0)
H3.90.1200.10 Alpha Beta Alpha-Beta Complex Aminoglycoside 3'-phosphotransferase Chain: A, domain 2CATH (4.3.0)
J3.30.200.20 Alpha Beta 2-Layer Sandwich Phosphorylase Kinase domain 1CATH (4.3.0)
J3.90.1200.10 Alpha Beta Alpha-Beta Complex Aminoglycoside 3'-phosphotransferase Chain: A, domain 2CATH (4.3.0)
L3.30.200.20 Alpha Beta 2-Layer Sandwich Phosphorylase Kinase domain 1CATH (4.3.0)
L3.90.1200.10 Alpha Beta Alpha-Beta Complex Aminoglycoside 3'-phosphotransferase Chain: A, domain 2CATH (4.3.0)
I3.30.200.20 Alpha Beta 2-Layer Sandwich Phosphorylase Kinase domain 1CATH (4.3.0)
I3.90.1200.10 Alpha Beta Alpha-Beta Complex Aminoglycoside 3'-phosphotransferase Chain: A, domain 2CATH (4.3.0)
K3.30.200.20 Alpha Beta 2-Layer Sandwich Phosphorylase Kinase domain 1CATH (4.3.0)
K3.90.1200.10 Alpha Beta Alpha-Beta Complex Aminoglycoside 3'-phosphotransferase Chain: A, domain 2CATH (4.3.0)

AMR Gene: CARD Annotation CARD Database Homepage

ChainsAccessionShort NameDescriptionProvenance Source (Version)
A, B, C, D, E
ARO:3002641APH(3')-IaAPH(3')-Ia is a transposon-encoded aminoglycoside phosphotransferase in E. coli and S. enterica. It is identical at the protein sequence to APH(3')-Ic, an aminoglycoside phosphotransferase encoded by plasmids, transposons and genomic islands in K. pneumoniae, A. baumannii, S. marcescens, Corynebacterium spp., Photobacterium spp. and Citrobacter spp.CARD (3.3.0)

AMR Gene Family: CARD Annotation CARD Database Homepage

ChainsAccessionGene FamilyDrug Class Resistance MachanismProvenance Source (Version)
A, B, C, D, E
ARO:3000126APH(3')aminoglycoside antibioticantibiotic inactivationCARD (3.3.0)