4GL9

Crystal structure of inhibitory protein SOCS3 in complex with JAK2 kinase domain and fragment of GP130 intracellular domain

External Resource: Annotation

Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Protein Modification Annotation

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
A	SCOP2 Family	Protein kinases catalytic domain-like	8069248	4003661	SCOP2 (2022-06-29)
A	SCOP2 Superfamily	Protein kinase-like (PK-like)	8069249	3000066	SCOP2 (2022-06-29)
B	SCOP2B Superfamily	Protein kinase-like (PK-like)	8069249	3000066	SCOP2B (2022-06-29)
D [auth C]	SCOP2B Superfamily	Protein kinase-like (PK-like)	8069249	3000066	SCOP2B (2022-06-29)
I [auth D]	SCOP2B Superfamily	Protein kinase-like (PK-like)	8069249	3000066	SCOP2B (2022-06-29)
G [auth E]	SCOP2 Family	SH2 domain	8069280	4001650	SCOP2 (2022-06-29)
G [auth E]	SCOP2 Superfamily	SH2 domain	8069281	3000197	SCOP2 (2022-06-29)
J [auth F]	SCOP2B Superfamily	SH2 domain	8069281	3000197	SCOP2B (2022-06-29)
K [auth G]	SCOP2B Superfamily	SH2 domain	8069281	3000197	SCOP2B (2022-06-29)
L [auth H]	SCOP2B Superfamily	SH2 domain	8069281	3000197	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
A	Pkinase_Tyr	e4gl9A1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
B	Pkinase_Tyr	e4gl9B1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
D [auth C]	Pkinase_Tyr	e4gl9C1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
I [auth D]	Pkinase_Tyr	e4gl9D1	A: a+b complex topology	X: Protein kinase/SAICAR synthase/ATP-grasp (From Homology)	H: Protein kinase/SAICAR synthase/ATP-grasp	T: Protein kinase	F: Pkinase_Tyr	ECOD (1.6)
G [auth E]	SH2	e4gl9E2	A: a+b two layers	X: SH2 (From Topology)	H: SH2 (From Topology)	T: SH2	F: SH2	ECOD (1.6)
J [auth F]	SH2	e4gl9F2	A: a+b two layers	X: SH2 (From Topology)	H: SH2 (From Topology)	T: SH2	F: SH2	ECOD (1.6)
K [auth G]	SH2	e4gl9G2	A: a+b two layers	X: SH2 (From Topology)	H: SH2 (From Topology)	T: SH2	F: SH2	ECOD (1.6)
L [auth H]	SH2	e4gl9H2	A: a+b two layers	X: SH2 (From Topology)	H: SH2 (From Topology)	T: SH2	F: SH2	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
A	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
A	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
B	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
B	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
D [auth C]	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
D [auth C]	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
I [auth D]	3.30.200.20	Alpha Beta	2-Layer Sandwich	Phosphorylase Kinase	domain 1	CATH (4.3.0)
I [auth D]	1.10.510.10	Mainly Alpha	Orthogonal Bundle	Transferase(Phosphotransferase)	domain 1	CATH (4.3.0)
G [auth E]	3.30.505.10	Alpha Beta	2-Layer Sandwich	SHC Adaptor Protein	SH2 domain	CATH (4.3.0)
J [auth F]	3.30.505.10	Alpha Beta	2-Layer Sandwich	SHC Adaptor Protein	SH2 domain	CATH (4.3.0)
K [auth G]	3.30.505.10	Alpha Beta	2-Layer Sandwich	SHC Adaptor Protein	SH2 domain	CATH (4.3.0)
L [auth H]	3.30.505.10	Alpha Beta	2-Layer Sandwich	SHC Adaptor Protein	SH2 domain	CATH (4.3.0)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, B, D [auth C], I [auth D]	PF07714	Protein tyrosine and serine/threonine kinase (PK_Tyr_Ser-Thr)	Protein tyrosine and serine/threonine kinase	Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosph ...	Protein phosphorylation, which plays a key role in most cellular activities, is a reversible process mediated by protein kinases and phosphoprotein phosphatases. Protein kinases catalyse the transfer of the gamma phosphate from nucleotide triphosphates (often ATP) to one or more amino acid residues in a protein substrate side chain, resulting in a conformational change affecting protein function. Phosphoprotein phosphatases catalyse the reverse process. Protein kinases fall into three broad classes, characterised with respect to substrate specificity [1]; Serine/threonine-protein kinases, tyrosine-protein kinases, and dual specificity protein kinases (e.g. MEK - phosphorylates both Thr and Tyr on target proteins). This entry represents the catalytic domain found in a number of serine/threonine- and tyrosine-protein kinases. It does not include the catalytic domain of dual specificity kinases.	Domain
G [auth E], J [auth F], K [auth G], L [auth H]	PF00017	SH2 domain (SH2)	SH2 domain	-	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
A, B, D [auth C], I [auth D]	Tyrosine-protein kinase	protein binding binding histone binding protein tyrosine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding protein binding binding histone binding protein tyrosine kinase activity catalytic activity, acting on a protein kinase activity protein kinase activity transferase activity catalytic activity phosphotransferase activity, alcohol group as acceptor transferase activity, transferring phosphorus-containing groups adenyl ribonucleotide binding nucleotide binding purine ribonucleotide binding purine ribonucleoside triphosphate binding nucleoside phosphate binding ion binding purine nucleotide binding organic cyclic compound binding anion binding adenyl nucleotide binding ATP binding heterocyclic compound binding carbohydrate derivative binding ribonucleotide binding small molecule binding non-membrane spanning protein tyrosine kinase activity cation binding metal ion binding angiotensin receptor binding signaling receptor binding type 1 angiotensin receptor binding G protein-coupled receptor binding kinase binding enzyme binding protein kinase binding tetrapyrrole binding heme binding insulin receptor substrate binding interleukin-12 receptor binding cytokine receptor binding growth factor receptor binding histone H3Y41 kinase activity histone H3 kinase activity histone modifying activity histone kinase activity phosphatidylinositol 3-kinase binding peptide hormone receptor binding hormone receptor binding identical protein binding SH2 domain binding protein domain specific binding growth hormone receptor binding acetylcholine receptor binding	regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process metabolic process regulation of nitric oxide metabolic process regulation of biosynthetic process regulation of nitric oxide biosynthetic process regulation of biological process biological regulation positive regulation of biological process reactive nitrogen species metabolic process positive regulation of nitric oxide metabolic process nitric oxide metabolic process positive regulation of metabolic process nitric oxide biosynthetic process biosynthetic process positive regulation of biosynthetic process metabolic process regulation of nitric oxide metabolic process positive regulation of nitric oxide biosynthetic process regulation of metabolic process cellular response to stimulus positive regulation of cell communication cell surface receptor protein serine/threonine kinase signaling pathway regulation of cellular process positive regulation of signal transduction response to stimulus signaling regulation of transmembrane receptor protein serine/threonine kinase signaling pathway regulation of signal transduction intracellular signal transduction cell communication positive regulation of response to stimulus regulation of intracellular signal transduction intracellular signaling cassette signal transduction enzyme-linked receptor protein signaling pathway positive regulation of cellular process regulation of signaling cell surface receptor signaling pathway positive regulation of intracellular signal transduction positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway SMAD protein signal transduction regulation of response to stimulus regulation of cell communication cellular process regulation of SMAD protein signal transduction positive regulation of SMAD protein signal transduction positive regulation of signaling cell surface receptor signaling pathway via STAT peptidyl-tyrosine modification peptidyl-amino acid modification phosphate-containing compound metabolic process protein metabolic process protein modification process phosphorus metabolic process tyrosine phosphorylation of STAT protein protein phosphorylation phosphorylation cellular metabolic process primary metabolic process macromolecule modification macromolecule metabolic process peptidyl-tyrosine phosphorylation cell surface receptor signaling pathway via JAK-STAT regulation of programmed cell death positive regulation of apoptotic signaling pathway positive regulation of programmed cell death regulation of apoptotic process cell death positive regulation of apoptotic process apoptotic signaling pathway apoptotic process programmed cell death regulation of apoptotic signaling pathway regulation of cell-substrate adhesion positive regulation of cell adhesion regulation of cell adhesion cell-substrate adhesion cell adhesion positive regulation of cell-substrate adhesion response to chemical response to antibiotic response to cytokine cellular response to interleukin-12 cytokine-mediated signaling pathway response to peptide response to interleukin-12 cellular response to cytokine stimulus interleukin-12-mediated signaling pathway positive regulation of DNA-binding transcription factor activity cellular biosynthetic process RNA metabolic process regulation of primary metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process positive regulation of molecular function nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of cellular metabolic process regulation of macromolecule metabolic process nucleobase-containing compound biosynthetic process gene expression macromolecule biosynthetic process nucleic acid metabolic process regulation of cellular biosynthetic process regulation of molecular function regulation of gene expression regulation of DNA-binding transcription factor activity regulation of macromolecule biosynthetic process regulation of DNA-templated transcription negative regulation of biological process negative regulation of cell adhesion cell-cell adhesion negative regulation of cell-cell adhesion negative regulation of cellular process regulation of cell-cell adhesion platelet-derived growth factor receptor signaling pathway cell surface receptor protein tyrosine kinase signaling pathway multicellular organismal process cell activation regulation of cell activation positive regulation of cell activation positive regulation of multicellular organismal process regulation of multicellular organismal process post-translational protein modification biological process involved in interspecies interaction between organisms response to type II interferon cellular response to type II interferon response to biotic stimulus interferon-mediated signaling pathway response to stress innate immune response response to external biotic stimulus immune response response to other organism defense response type II interferon-mediated signaling pathway defense response to symbiont response to external stimulus immune system process defense response to other organism intracellular receptor signaling pathway response to lipid hormone-mediated signaling pathway nuclear receptor-mediated mineralocorticoid signaling pathway cellular response to endogenous stimulus response to hormone response to steroid hormone nuclear receptor-mediated steroid hormone signaling pathway cellular response to steroid hormone stimulus response to organic cyclic compound steroid hormone receptor signaling pathway cellular response to hormone stimulus response to endogenous stimulus cellular response to organic cyclic compound nuclear receptor-mediated corticosteroid signaling pathway cellular response to chemical stimulus cellular response to lipid nuclear receptor-mediated signaling pathway interleukin-5-mediated signaling pathway negative regulation of cardiac muscle cell apoptotic process muscle cell apoptotic process negative regulation of programmed cell death regulation of cardiac muscle cell apoptotic process regulation of muscle cell apoptotic process cardiac muscle cell apoptotic process negative regulation of apoptotic process regulation of striated muscle cell apoptotic process striated muscle cell apoptotic process negative regulation of muscle cell apoptotic process negative regulation of striated muscle cell apoptotic process collagen-activated signaling pathway positive regulation of cell population proliferation regulation of leukocyte activation T cell activation lymphocyte proliferation positive regulation of leukocyte activation regulation of immune system process positive regulation of immune system process regulation of leukocyte proliferation cell population proliferation positive regulation of T cell activation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation regulation of cell population proliferation mononuclear cell proliferation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte proliferation positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation positive regulation of mononuclear cell proliferation T cell proliferation regulation of lymphocyte proliferation regulation of T cell activation regulation of T cell proliferation regulation of mononuclear cell proliferation regulation of lymphocyte activation myeloid leukocyte activation macrophage activation leukocyte activation involved in inflammatory response microglial cell activation inflammatory response glial cell activation neuroinflammatory response developmental process cellular developmental process myeloid cell differentiation hemopoiesis cell differentiation anatomical structure development cell development regulation of catalytic activity positive regulation of protein metabolic process positive regulation of peptidase activity positive regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity involved in apoptotic process regulation of proteolysis proteolysis regulation of endopeptidase activity positive regulation of macromolecule metabolic process activation of cysteine-type endopeptidase activity involved in apoptotic process regulation of cysteine-type endopeptidase activity regulation of protein metabolic process regulation of peptidase activity positive regulation of catalytic activity positive regulation of hydrolase activity positive regulation of cysteine-type endopeptidase activity regulation of hydrolase activity positive regulation of endopeptidase activity positive regulation of proteolysis positive regulation of locomotion regulation of cell motility positive regulation of cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion positive regulation of cellular metabolic process positive regulation of macromolecule biosynthetic process cytokine production regulation of cytokine production interleukin-17 production regulation of interleukin-17 production positive regulation of gene expression positive regulation of interleukin-17 production positive regulation of cytokine production positive regulation of cellular biosynthetic process regulation of MHC class II biosynthetic process MHC class II biosynthetic process positive regulation of MHC class II biosynthetic process G protein-coupled receptor signaling pathway regulation of body fluid levels positive regulation of platelet activation coagulation regulation of biological quality response to wounding wound healing hemostasis blood coagulation regulation of platelet activation platelet activation positive regulation of phosphorylation positive regulation of receptor signaling pathway via STAT regulation of transferase activity positive regulation of phosphate metabolic process regulation of phosphate metabolic process regulation of receptor signaling pathway via JAK-STAT positive regulation of protein phosphorylation positive regulation of phosphorus metabolic process positive regulation of kinase activity regulation of kinase activity activation of protein kinase activity regulation of phosphorus metabolic process regulation of receptor signaling pathway via STAT regulation of protein modification process regulation of protein phosphorylation positive regulation of receptor signaling pathway via JAK-STAT positive regulation of protein modification process positive regulation of protein kinase activity activation of Janus kinase activity positive regulation of transferase activity regulation of protein kinase activity regulation of phosphorylation regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production response to oxidative stress response to granulocyte macrophage colony-stimulating factor interleukin-3-mediated signaling pathway response to oxygen-containing compound response to lipopolysaccharide response to bacterium response to molecule of bacterial origin regulation of type II interferon production type II interferon production positive regulation of type II interferon production response to amine response to nitrogen compound regulation of NK T cell proliferation positive regulation of NK T cell proliferation regulation of alpha-beta T cell activation positive regulation of alpha-beta T cell proliferation alpha-beta T cell proliferation alpha-beta T cell activation NK T cell proliferation positive regulation of alpha-beta T cell activation positive regulation of NK T cell activation regulation of alpha-beta T cell proliferation regulation of NK T cell activation NK T cell activation cellular response to nitrogen compound response to peptide hormone cellular response to growth hormone stimulus growth hormone receptor signaling pathway via JAK-STAT growth hormone receptor signaling pathway cellular response to peptide hormone stimulus cellular response to oxygen-containing compound response to growth hormone regulation of DNA binding regulation of binding positive regulation of binding positive regulation of DNA binding positive regulation of epithelial cell apoptotic process regulation of epithelial cell apoptotic process epithelial cell apoptotic process adaptive immune response regulation of defense response regulation of response to external stimulus regulation of inflammatory response positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stress positive regulation of defense response epithelium development mammary gland epithelium development mammary gland development gland development animal organ development tissue development extrinsic apoptotic signaling pathway regulation of developmental process regulation of cell differentiation positive regulation of developmental process positive regulation of cell differentiation homotypic cell-cell adhesion regulation of homotypic cell-cell adhesion platelet aggregation regulation of platelet aggregation positive regulation of homotypic cell-cell adhesion positive regulation of platelet aggregation response to ketone cellular response to ketone cellular response to dexamethasone stimulus response to glucocorticoid cellular response to glucocorticoid stimulus cellular response to corticosteroid stimulus response to corticosteroid response to dexamethasone protein localization regulation of localization cellular localization establishment of protein localization nitrogen compound transport regulation of protein localization nucleocytoplasmic transport transport positive regulation of nucleocytoplasmic transport nuclear transport positive regulation of establishment of protein localization regulation of protein localization to nucleus positive regulation of protein transport localization import into nucleus regulation of protein import into nucleus cellular macromolecule localization establishment of localization in cell protein import into nucleus positive regulation of intracellular transport regulation of intracellular transport regulation of transport positive regulation of protein localization to nucleus regulation of establishment of protein localization positive regulation of protein import into nucleus intracellular transport regulation of nucleocytoplasmic transport protein localization to nucleus regulation of protein transport establishment of localization positive regulation of transport establishment of protein localization to organelle regulation of cellular localization protein transport macromolecule localization protein localization to organelle positive regulation of protein localization regulation of intracellular protein transport positive regulation of intracellular protein transport intracellular protein transport interleukin-1 production regulation of interleukin-1 beta production positive regulation of interleukin-1 beta production positive regulation of interleukin-1 production regulation of interleukin-1 production interleukin-1 beta production protein autophosphorylation trans-synaptic signaling modulation of chemical synaptic transmission cell-cell signaling chemical synaptic transmission synaptic signaling regulation of trans-synaptic signaling anterograde trans-synaptic signaling positive regulation of signaling receptor activity regulation of signaling receptor activity cellular response to interleukin-3 response to interleukin-3 positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway cellular response to tumor necrosis factor tumor necrosis factor-mediated signaling pathway response to tumor necrosis factor homeostatic process erythrocyte differentiation multicellular organismal-level homeostasis homeostasis of number of cells myeloid cell homeostasis erythrocyte homeostasis granulocyte-macrophage colony-stimulating factor signaling pathway positive regulation of DNA-templated transcription transcription by RNA polymerase II regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of growth hormone receptor signaling pathway positive regulation of growth hormone receptor signaling pathway positive regulation of cytosolic calcium ion concentration adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of T-helper 17 type immune response regulation of adaptive immune response positive regulation of T-helper 17 type immune response regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of immune response regulation of immune response positive regulation of adaptive immune response T-helper 17 type immune response heart process system process regulation of heart contraction regulation of system process negative regulation of blood circulation negative regulation of heart contraction circulatory system process regulation of blood circulation heart contraction negative regulation of multicellular organismal process blood circulation regulation of vascular associated smooth muscle cell proliferation positive regulation of vascular associated smooth muscle cell proliferation regulation of smooth muscle cell proliferation smooth muscle cell proliferation positive regulation of smooth muscle cell proliferation muscle cell proliferation vascular associated smooth muscle cell proliferation symbiont-induced defense-related programmed cell death cellular response to lipopolysaccharide cellular response to molecule of bacterial origin cellular response to biotic stimulus skeletal muscle satellite cell proliferation positive regulation of growth factor dependent skeletal muscle satellite cell proliferation positive regulation of skeletal muscle cell proliferation positive regulation of skeletal muscle satellite cell proliferation regulation of skeletal muscle satellite cell proliferation skeletal muscle cell proliferation regulation of skeletal muscle cell proliferation striated muscle cell proliferation positive regulation of natural killer cell proliferation regulation of natural killer cell activation positive regulation of natural killer cell activation natural killer cell activation natural killer cell proliferation regulation of natural killer cell proliferation regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction phosphatidylinositol 3-kinase/protein kinase B signal transduction regulation of postsynapse to nucleus signaling pathway postsynaptic signal transduction postsynapse to nucleus signaling pathway neuron apoptotic process negative regulation of neuron apoptotic process regulation of neuron apoptotic process regulation of nitric-oxide synthase biosynthetic process nitric-oxide synthase biosynthetic process positive regulation of nitric-oxide synthase biosynthetic process adaptive thermogenesis regulation of cold-induced thermogenesis cold-induced thermogenesis temperature homeostasis positive regulation of cold-induced thermogenesis positive regulation of MAPK cascade regulation of MAPK cascade MAPK cascade multicellular organism development post-embryonic development post-embryonic hemopoiesis negative regulation of cell population proliferation positive regulation of peptidyl-tyrosine phosphorylation regulation of tyrosine phosphorylation of STAT protein regulation of peptidyl-tyrosine phosphorylation positive regulation of tyrosine phosphorylation of STAT protein cell projection organization neuron projection development regeneration response to axon injury neuron projection regeneration cellular component organization neurogenesis axon regeneration neuron differentiation cellular response to stress cellular component organization or biogenesis system development plasma membrane bounded cell projection organization nervous system development axon development generation of neurons neuron development response to hydroperoxide positive regulation of insulin secretion regulation of peptide hormone secretion regulation of hormone levels positive regulation of peptide hormone secretion establishment of protein localization to extracellular region protein secretion regulation of protein secretion regulation of secretion regulation of hormone secretion regulation of peptide secretion positive regulation of secretion by cell hormone secretion protein localization to extracellular region peptide secretion secretion by cell regulation of secretion by cell positive regulation of hormone secretion positive regulation of secretion amide transport signal release positive regulation of peptide secretion secretion regulation of peptide transport export from cell positive regulation of protein secretion peptide transport regulation of insulin secretion peptide hormone secretion hormone transport insulin secretion intrinsic apoptotic signaling pathway in response to oxidative stress intrinsic apoptotic signaling pathway	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery extrinsic component of plasma membrane cytoplasmic side of plasma membrane cytoplasmic side of membrane membrane plasma membrane extrinsic component of membrane extrinsic component of cytoplasmic side of plasma membrane side of membrane anchoring junction intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery extrinsic component of plasma membrane cytoplasmic side of plasma membrane cytoplasmic side of membrane membrane plasma membrane extrinsic component of membrane extrinsic component of cytoplasmic side of plasma membrane side of membrane anchoring junction cell junction focal adhesion cell-substrate junction membrane microdomain membrane raft plasma membrane raft plasma membrane region caveola intracellular organelle organelle euchromatin intracellular non-membrane-bounded organelle chromatin chromosome non-membrane-bounded organelle protein-containing complex plasma membrane protein complex interleukin-23 receptor complex plasma membrane signaling receptor complex membrane protein complex receptor complex synapse glutamatergic synapse cytoskeleton interleukin-12 receptor complex postsynapse endomembrane system membrane-bounded organelle nucleus membrane-enclosed lumen intracellular membrane-bounded organelle intracellular organelle lumen nucleoplasm organelle lumen nuclear lumen granulocyte macrophage colony-stimulating factor receptor complex
C [auth I], E [auth K], F [auth J], H [auth L]	Interleukin-6 receptor subunit beta	protein tyrosine kinase activator activity enzyme regulator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity protein kinase activator activity protein kinase regulator activity kinase regulator activity ciliary neurotrophic factor receptor binding protein binding binding signaling receptor binding cytokine receptor binding protein tyrosine kinase activator activity enzyme regulator activity kinase activator activity enzyme activator activity molecular function activator activity molecular function regulator activity protein kinase activator activity protein kinase regulator activity kinase regulator activity ciliary neurotrophic factor receptor binding protein binding binding signaling receptor binding cytokine receptor binding interleukin-6 binding growth factor binding cytokine binding molecular transducer activity coreceptor activity signaling receptor activity scaffold protein binding oncostatin-M receptor activity transmembrane signaling receptor activity cytokine receptor activity immune receptor activity interleukin-6 receptor activity interleukin-6 receptor binding growth factor receptor binding leukemia inhibitory factor receptor activity ciliary neurotrophic factor receptor activity identical protein binding	cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation regulation of signal transduction cell communication Notch signaling pathway regulation of response to stimulus regulation of Notch signaling pathway regulation of cell communication cellular response to stimulus regulation of biological process regulation of signaling regulation of cellular process cell surface receptor signaling pathway response to stimulus signaling biological regulation regulation of signal transduction cell communication Notch signaling pathway regulation of response to stimulus regulation of Notch signaling pathway regulation of cell communication cellular process signal transduction response to cytokine cytokine-mediated signaling pathway response to peptide response to chemical cellular response to cytokine stimulus neutral lipid metabolic process cellular metabolic process primary metabolic process triglyceride metabolic process cellular lipid metabolic process metabolic process glycerolipid metabolic process triglyceride mobilization acylglycerol metabolic process lipid metabolic process positive regulation of locomotion regulation of cell motility positive regulation of smooth muscle cell migration regulation of smooth muscle cell migration positive regulation of biological process positive regulation of cell migration smooth muscle cell migration muscle cell migration regulation of locomotion positive regulation of cell motility regulation of cell migration cell migration cell motility locomotion positive regulation of cellular process neuron apoptotic process negative regulation of neuron apoptotic process negative regulation of programmed cell death regulation of apoptotic process negative regulation of biological process regulation of programmed cell death cell death negative regulation of apoptotic process negative regulation of cellular process apoptotic process programmed cell death regulation of neuron apoptotic process cell population proliferation positive regulation of cell population proliferation regulation of cell population proliferation interleukin-6-mediated signaling pathway response to interleukin-6 cellular response to interleukin-6 developmental process regulation of osteoblast differentiation multicellular organismal process cellular developmental process regulation of developmental process regulation of cell differentiation osteoblast differentiation positive regulation of developmental process positive regulation of osteoblast differentiation ossification positive regulation of cell differentiation cell differentiation epithelium development digestive system development intestinal epithelial cell differentiation tube development intestinal epithelial cell development cell development tissue development digestive tract development epithelial cell differentiation multicellular organism development epithelial cell development columnar/cuboidal epithelial cell development anatomical structure development columnar/cuboidal epithelial cell differentiation system development positive regulation of phosphorylation positive regulation of phosphate metabolic process regulation of primary metabolic process positive regulation of metabolic process regulation of phosphate metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process positive regulation of macromolecule metabolic process protein modification process phosphorus metabolic process positive regulation of protein phosphorylation tyrosine phosphorylation of STAT protein protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process regulation of cellular metabolic process macromolecule modification regulation of phosphorus metabolic process macromolecule metabolic process regulation of metabolic process cell surface receptor signaling pathway via STAT regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process positive regulation of cellular metabolic process peptidyl-tyrosine modification positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process protein metabolic process regulation of tyrosine phosphorylation of STAT protein regulation of peptidyl-tyrosine phosphorylation regulation of macromolecule metabolic process positive regulation of tyrosine phosphorylation of STAT protein regulation of phosphorylation peptidyl-tyrosine phosphorylation cell surface receptor signaling pathway via JAK-STAT regulation of biological quality negative regulation of cytosolic calcium ion concentration interleukin-27-mediated signaling pathway positive regulation of cell communication positive regulation of signal transduction positive regulation of response to stimulus positive regulation of Notch signaling pathway positive regulation of signaling regulation of leukocyte activation regulation of cell activation positive regulation of cell activation T cell activation lymphocyte proliferation positive regulation of leukocyte activation regulation of immune system process positive regulation of immune system process regulation of leukocyte proliferation positive regulation of T cell activation positive regulation of lymphocyte proliferation positive regulation of T cell proliferation mononuclear cell proliferation regulation of leukocyte cell-cell adhesion positive regulation of leukocyte proliferation positive regulation of multicellular organismal process positive regulation of leukocyte cell-cell adhesion lymphocyte activation leukocyte proliferation leukocyte cell-cell adhesion leukocyte activation positive regulation of cell-cell adhesion positive regulation of lymphocyte activation cell adhesion cell-cell adhesion positive regulation of mononuclear cell proliferation regulation of multicellular organismal process regulation of cell-cell adhesion T cell proliferation regulation of lymphocyte proliferation positive regulation of cell adhesion regulation of cell adhesion cell activation regulation of T cell activation regulation of T cell proliferation immune system process regulation of mononuclear cell proliferation regulation of lymphocyte activation interleukin-11-mediated signaling pathway carbohydrate metabolic process energy derivation by oxidation of organic compounds glycogen metabolic process generation of precursor metabolites and energy glucan metabolic process polysaccharide metabolic process energy reserve metabolic process positive regulation of nervous system development astrocyte differentiation regulation of neurogenesis regulation of gliogenesis regulation of astrocyte differentiation positive regulation of gliogenesis regulation of cell development regulation of nervous system development neurogenesis gliogenesis positive regulation of neurogenesis positive regulation of astrocyte differentiation regulation of multicellular organismal development positive regulation of cell development regulation of glial cell differentiation nervous system development positive regulation of glial cell differentiation central nervous system development glial cell differentiation	cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane protein-containing complex plasma membrane protein complex plasma membrane signaling receptor complex ciliary neurotrophic factor receptor complex membrane protein complex receptor complex membrane microdomain cell periphery cell surface membrane plasma membrane cellular anatomical entity external side of plasma membrane side of membrane protein-containing complex plasma membrane protein complex plasma membrane signaling receptor complex ciliary neurotrophic factor receptor complex membrane protein complex receptor complex membrane microdomain membrane raft somatodendritic compartment cell projection dendrite dendritic tree neuron projection plasma membrane bounded cell projection interleukin-6 receptor complex oncostatin-M receptor complex cell body neuronal cell body neuronal cell body membrane cell body membrane
G [auth E], J [auth F], K [auth G], L [auth H]	Suppressor of cytokine signaling 3,Suppressor of cytokine signaling 3,Suppressor of cytokine signaling 3,Suppressor of cytokine signaling 3	enzyme regulator activity molecular function regulator activity 1-phosphatidylinositol-3-kinase regulator activity kinase regulator activity phosphoprotein binding phosphotyrosine residue binding protein binding binding protein phosphorylated amino acid binding regulatory RNA binding RNA binding organic cyclic compound binding miRNA binding nucleic acid binding enzyme regulator activity molecular function regulator activity 1-phosphatidylinositol-3-kinase regulator activity kinase regulator activity phosphoprotein binding phosphotyrosine residue binding protein binding binding protein phosphorylated amino acid binding regulatory RNA binding RNA binding organic cyclic compound binding miRNA binding nucleic acid binding protein kinase inhibitor activity protein tyrosine kinase inhibitor activity molecular function inhibitor activity enzyme inhibitor activity protein kinase regulator activity kinase inhibitor activity	cellular response to stimulus regulation of signaling regulation of biological process regulation of cellular process response to stimulus negative regulation of signaling signaling negative regulation of response to stimulus biological regulation negative regulation of biological process regulation of signal transduction negative regulation of signal transduction negative regulation of cell communication cell communication regulation of response to stimulus cellular response to stimulus regulation of signaling regulation of biological process regulation of cellular process response to stimulus negative regulation of signaling signaling negative regulation of response to stimulus biological regulation negative regulation of biological process regulation of signal transduction negative regulation of signal transduction negative regulation of cell communication cell communication regulation of response to stimulus negative regulation of cellular process regulation of cell communication cellular process signal transduction developmental process cellular developmental process cell differentiation response to peptide response to chemical cellular response to interleukin-17 response to interleukin-17 response to cytokine cellular response to cytokine stimulus phosphatidylinositol metabolic process glycerophospholipid biosynthetic process cellular biosynthetic process cellular metabolic process glycerophospholipid metabolic process lipid biosynthetic process primary metabolic process phosphatidylinositol phosphate biosynthetic process phospholipid biosynthetic process phosphatidylinositol biosynthetic process phospholipid metabolic process biosynthetic process glycerolipid biosynthetic process organophosphate metabolic process organophosphate biosynthetic process cellular lipid metabolic process phosphate-containing compound metabolic process metabolic process glycerolipid metabolic process phosphorus metabolic process lipid metabolic process regulation of defense response regulation of response to external stimulus negative regulation of inflammatory response defense response response to external stimulus regulation of inflammatory response response to stress negative regulation of response to external stimulus regulation of response to stress negative regulation of defense response inflammatory response protein ubiquitination macromolecule modification protein metabolic process macromolecule metabolic process post-translational protein modification protein modification process protein modification by small protein conjugation protein modification by small protein conjugation or removal multicellular organismal process chordate embryonic development labyrinthine layer development embryo development multicellular organism development embryonic placenta development embryo development ending in birth or egg hatching anatomical structure development embryonic organ development epithelium development placenta development embryonic morphogenesis animal organ development morphogenesis of an epithelium branching involved in labyrinthine layer morphogenesis tissue development in utero embryonic development embryonic placenta morphogenesis anatomical structure morphogenesis labyrinthine layer morphogenesis tissue morphogenesis morphogenesis of a branching structure morphogenesis of a branching epithelium regulation of developmental process positive regulation of biological process regulation of cell differentiation positive regulation of developmental process positive regulation of cell differentiation positive regulation of cellular process placenta blood vessel development vasculature development circulatory system development blood vessel development system development cellular response to nitrogen compound response to peptide hormone insulin receptor signaling pathway regulation of cellular response to insulin stimulus cell surface receptor protein tyrosine kinase signaling pathway cellular response to endogenous stimulus response to hormone enzyme-linked receptor protein signaling pathway cellular response to hormone stimulus cell surface receptor signaling pathway response to endogenous stimulus regulation of insulin receptor signaling pathway response to oxygen-containing compound cellular response to peptide hormone stimulus response to nitrogen compound cellular response to oxygen-containing compound cellular response to chemical stimulus negative regulation of cellular response to insulin stimulus negative regulation of insulin receptor signaling pathway response to insulin cellular response to insulin stimulus cell surface receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT negative regulation of cellular metabolic process regulation of primary metabolic process regulation of phosphate metabolic process peptidyl-amino acid modification negative regulation of protein modification process regulation of receptor signaling pathway via JAK-STAT negative regulation of protein metabolic process tyrosine phosphorylation of STAT protein negative regulation of receptor signaling pathway via JAK-STAT protein phosphorylation phosphorylation regulation of protein metabolic process negative regulation of metabolic process regulation of cellular metabolic process negative regulation of protein phosphorylation regulation of phosphorus metabolic process regulation of receptor signaling pathway via STAT regulation of metabolic process regulation of protein modification process regulation of protein phosphorylation negative regulation of phosphate metabolic process peptidyl-tyrosine modification negative regulation of macromolecule metabolic process negative regulation of peptidyl-tyrosine phosphorylation regulation of tyrosine phosphorylation of STAT protein regulation of peptidyl-tyrosine phosphorylation regulation of macromolecule metabolic process negative regulation of tyrosine phosphorylation of STAT protein negative regulation of phosphorus metabolic process regulation of phosphorylation negative regulation of phosphorylation peptidyl-tyrosine phosphorylation negative regulation of receptor signaling pathway via STAT intracellular signal transduction response to leukemia inhibitory factor cellular response to leukemia inhibitory factor	intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery cytoplasmic side of plasma membrane cytoplasmic side of membrane membrane plasma membrane side of membrane phosphatidylinositol 3-kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex intracellular anatomical structure cytoplasm cellular anatomical entity cytosol cell periphery cytoplasmic side of plasma membrane cytoplasmic side of membrane membrane plasma membrane side of membrane phosphatidylinositol 3-kinase complex transferase complex, transferring phosphorus-containing groups protein-containing complex catalytic complex membrane protein complex transferase complex extrinsic component of membrane

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, B, D [auth C], I [auth D]	IPR020635	Tyrosine-protein kinase, catalytic domain	Domain
A, B, D [auth C], I [auth D]	IPR000719	Protein kinase domain	Domain
A, B, D [auth C], I [auth D]	IPR041381	JAK1-3/TYK2, pleckstrin homology-like domain	Domain
A, B, D [auth C], I [auth D]	IPR017441	Protein kinase, ATP binding site	Binding Site
A, B, D [auth C], I [auth D]	IPR036860	SH2 domain superfamily	Homologous Superfamily
A, B, D [auth C], I [auth D]	IPR001245	Serine-threonine/tyrosine-protein kinase, catalytic domain	Domain
A, B, D [auth C], I [auth D]	IPR051286	Janus Kinase (JAK)	Family
A, B, D [auth C], I [auth D]	IPR041046	JAK, FERM F2 lobe domain	Domain
A, B, D [auth C], I [auth D]	IPR019749	Band 4.1 domain	Domain
A, B, D [auth C], I [auth D]	IPR020693	Tyrosine-protein kinase, non-receptor Jak2	Family
A, B, D [auth C], I [auth D]	IPR035860	Tyrosine-protein kinase JAK2, SH2 domain	Domain
A, B, D [auth C], I [auth D]	IPR037838	JAK2, FERM domain C-lobe	Domain
A, B, D [auth C], I [auth D]	IPR000299	FERM domain	Domain
A, B, D [auth C], I [auth D]	IPR016251	Tyrosine-protein kinase, non-receptor Jak/Tyk2	Family
A, B, D [auth C], I [auth D]	IPR008266	Tyrosine-protein kinase, active site	Active Site
A, B, D [auth C], I [auth D]	IPR019748	FERM central domain	Domain
A, B, D [auth C], I [auth D]	IPR035963	FERM superfamily, second domain	Homologous Superfamily
A, B, D [auth C], I [auth D]	IPR000980	SH2 domain	Domain
A, B, D [auth C], I [auth D]	IPR011993	PH-like domain superfamily	Homologous Superfamily
A, B, D [auth C], I [auth D]	IPR035588	Janus kinase 2, pseudokinase domain	Domain
A, B, D [auth C], I [auth D]	IPR035589	Janus kinase 2, catalytic domain	Domain
A, B, D [auth C], I [auth D]	IPR011009	Protein kinase-like domain superfamily	Homologous Superfamily
A, B, D [auth C], I [auth D]	IPR041155	FERM F1 lobe ubiquitin-like domain	Domain
C [auth I], E [auth K], F [auth J], H [auth L]	IPR003529	Long hematopoietin receptor, Gp130 family 2, conserved site	Conserved Site
C [auth I], E [auth K], F [auth J], H [auth L]	IPR050379	Type I Cytokine Receptor	Family
C [auth I], E [auth K], F [auth J], H [auth L]	IPR010457	Immunoglobulin C2-set-like, ligand-binding	Domain
C [auth I], E [auth K], F [auth J], H [auth L]	IPR015321	Type I cytokine receptor, cytokine-binding domain	Domain
C [auth I], E [auth K], F [auth J], H [auth L]	IPR003961	Fibronectin type III	Domain
C [auth I], E [auth K], F [auth J], H [auth L]	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
C [auth I], E [auth K], F [auth J], H [auth L]	IPR036116	Fibronectin type III superfamily	Homologous Superfamily
G [auth E], J [auth F], K [auth G], L [auth H]	IPR036860	SH2 domain superfamily	Homologous Superfamily
G [auth E], J [auth F], K [auth G], L [auth H]	IPR000980	SH2 domain	Domain
G [auth E], J [auth F], K [auth G], L [auth H]	IPR036036	SOCS box-like domain superfamily	Homologous Superfamily
G [auth E], J [auth F], K [auth G], L [auth H]	IPR035863	SOCS3, SH2 domain	Domain
G [auth E], J [auth F], K [auth G], L [auth H]	IPR001496	SOCS box domain	Domain
G [auth E], J [auth F], K [auth G], L [auth H]	IPR028414	Suppressor of cytokine signalling 3, SOCS box domain	Domain

Protein Modification Annotation

Modified Residue(s)
Chain	Residue(s)	Description
A, B, D [auth C], I [auth D]	PTR	Parent Component: TYR RESID: AA0039 PSI-MOD : O4'-phospho-L-tyrosine MOD:00048
C [auth I], E [auth K], F [auth J], H [auth L]	PTR	Parent Component: TYR RESID: AA0039 , AA0039 PSI-MOD : O4'-phospho-L-tyrosine MOD:00048 , O4'-phospho-L-tyrosine MOD:00048