4GRW

Structure of a complex of human IL-23 with 3 Nanobodies (Llama vHHs)

External Resource: Annotation

Domain Annotation: SCOP/SCOPe Classification
Domain Annotation: SCOP2 Classification
Domain Annotation: ECOD Classification
Domain Annotation: CATH
IMGT Antibody Annotation
SAbDab Antibody Annotation
Protein Family Annotation
Gene Ontology: Gene Product Annotation
InterPro: Protein Family Classification
Pharos: Disease Associations

Domain Annotation: SCOP/SCOPe Classification SCOP-e Database Homepage

Chains	Domain Info	Class	Fold	Superfamily	Family	Domain	Species	Provenance Source (Version)
F	d4grwf_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	(Lama glama ) [TaxId: 9844 ],	SCOPe (2.08)
J	d4grwj_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	(Lama glama ) [TaxId: 9844 ],	SCOPe (2.08)
E	d4grwe_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	(Lama glama ) [TaxId: 9844 ],	SCOPe (2.08)
G	d4grwg_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	(Lama glama ) [TaxId: 9844 ],	SCOPe (2.08)
H	d4grwh_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	(Lama glama ) [TaxId: 9844 ],	SCOPe (2.08)
I	d4grwi_	All beta proteins	Immunoglobulin-like beta-sandwich	Immunoglobulin	V set domains (antibody variable domain-like)	automated matches	(Lama glama ) [TaxId: 9844 ],	SCOPe (2.08)

Domain Annotation: SCOP2 Classification SCOP2 Database Homepage

Chains	Type	Family Name	Domain Identifier	Family Identifier	Provenance Source (Version)
B	SCOP2B Superfamily	Fibronectin type III	8055151	3002063	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Fibronectin type III	8055537	3002063	SCOP2B (2022-06-29)
B	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054841	3000071	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Fibronectin type III	8055537	3002063	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Immunoglobulin (Ig) domain-like	8054841	3000071	SCOP2B (2022-06-29)
D	SCOP2B Superfamily	Fibronectin type III	8055151	3002063	SCOP2B (2022-06-29)

Domain Annotation: ECOD Classification ECOD Database Homepage

Chains	Family Name	Domain Identifier	Architecture	Possible Homology	Homology	Topology	Family	Provenance Source (Version)
F	V-set_12	e4grwF1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
J	V-set_12	e4grwJ1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
C	IL6	e4grwC1	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: 4-helical cytokines (From Topology)	T: 4-helical cytokines	F: IL6	ECOD (1.6)
A	IL6	e4grwA3	A: alpha bundles	X: Ferritin/Heme oxygenase/4-helical cytokines	H: 4-helical cytokines (From Topology)	T: 4-helical cytokines	F: IL6	ECOD (1.6)
B	IL12p40_C	e4grwB7	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: IL12p40_C	ECOD (1.6)
B	Ig_5	e4grwB8	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Ig_5	ECOD (1.6)
B	fn3_6	e4grwB9	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: fn3_6	ECOD (1.6)
D	IL12p40_C	e4grwD1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: IL12p40_C	ECOD (1.6)
D	Ig_5	e4grwD2	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: Ig_5	ECOD (1.6)
D	fn3_6	e4grwD3	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: fn3_6	ECOD (1.6)
E	V-set_12	e4grwE1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
G	V-set_12	e4grwG1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_12	ECOD (1.6)
H	V-set_8	e4grwH1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)
I	V-set_8	e4grwI1	A: beta sandwiches	X: Immunoglobulin-like beta-sandwich	H: Immunoglobulin-related	T: Immunoglobulin/Fibronectin type III/E set domains/PapD-like	F: V-set_8	ECOD (1.6)

Domain Annotation: CATH CATH Database Homepage

Chain	Domain	Class	Architecture	Topology	Homology	Provenance Source (Version)
F	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
J	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
C	1.20.1250.10	Mainly Alpha	Up-down Bundle	Growth Hormone	Chain: A	CATH (4.3.0)
A	1.20.1250.10	Mainly Alpha	Up-down Bundle	Growth Hormone	Chain: A	CATH (4.3.0)
B	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
D	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
E	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
G	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
H	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)
I	2.60.40.10	Mainly Beta	Sandwich	Immunoglobulin-like	Immunoglobulins	CATH (4.3.0)

IMGT Antibody Annotation IMGT Database Homepage

Chain	Protein Name	Description	Organism Name	Gene Allele Name(s)	Domain Name(s)	Receptor Type	Receptor Description	Provenance Source
F, J	Nanobody 37D5	VH	Lama glama (llama)	IGHV3S101, IGHJ401	V-DOMAIN VH	IG	(VH)	IMGT (202446-0)
B, D	Interleukin-12 subunit beta	B2M	Homo sapiens (human)	IL12B*01	C-LIKE-DOMAIN C-LIKE	RPI	B2M	IMGT (202446-0)
E, G	Nanobody 124C4	VH	Lama glama (llama)	IGHV3S101, IGHV3S201, IGHJ3*01	V-DOMAIN VH	IG	(VH)	IMGT (202446-0)
H, I	Nanobody 22E11	VH	Lama glama (llama)	IGHV3S301, IGHJ401	V-DOMAIN VH	IG	(VH)	IMGT (202446-0)

SAbDab Antibody Annotation SAbDab Database Homepage

Chain	Chain Class	Chain Subclass	Chain Type	Antigen Name(s)	Provenance Source
F, J	Heavy Chain	IGHV1	-	interleukin-23 subunit alpha	SAbDab (2024-11-15)
E, G	Heavy Chain	IGHV1	-	interleukin-12 subunit beta	SAbDab (2024-11-15)
H, I	Heavy Chain	IGHV1	-	interleukin-12 subunit beta	SAbDab (2024-11-15)

Protein Family Annotation Pfam Database Homepage

Chains	Accession	Name	Description	Comments	Source
A, C	PF16649	Interleukin 23 subunit alpha (IL23)	Interleukin 23 subunit alpha	This family, interleukin 23 subunit alpha, is a heterodimer consisting of a 40 kDa subunit - p40 - that is shared with IL12 and a unique 19 kDa subunit - p19. IL23 is a pro-inflammatory cytokine that binds to adnectins and thus plays a key role in th ...	This family, interleukin 23 subunit alpha, is a heterodimer consisting of a 40 kDa subunit - p40 - that is shared with IL12 and a unique 19 kDa subunit - p19. IL23 is a pro-inflammatory cytokine that binds to adnectins and thus plays a key role in the pathogenesis of several autoimmune and inflammatory diseases. IL23 signalling on the cell membrane works through the interaction of four proteins, two of which are shared with the IL12-receptor complex; signalling through the cell membrane involves the combined aggregation of at least two receptor components and then the subsequent activation of the Jak/Tyk tyrosine kinases and the family of STAT transcription factors [1,2,3].	Domain
B, D	PF10420	Cytokine interleukin-12p40 C-terminus (IL12p40_C)	Cytokine interleukin-12p40 C-terminus	IL12p40_C is the largely beta stranded C-terminal, D3, domain of interleukin-12p40 or interleukin-12B. This interleukin is produced on stimulation by macrophage-engulfed micro-organisms and other stimuli, when it dimerises with interleukin-12p35 to f ...	IL12p40_C is the largely beta stranded C-terminal, D3, domain of interleukin-12p40 or interleukin-12B. This interleukin is produced on stimulation by macrophage-engulfed micro-organisms and other stimuli, when it dimerises with interleukin-12p35 to form a heterodimer which then binds to receptors on natural killer cells to activate them to destroy the micro-organisms [1]. This domain contains two disulfide bridges, one of which serves to bind p40 to p35 and the other to hold the beta strands within the domain together. The cupped shape of the p35 binding interface matches the elbow-like bend between D2 and D3 in p40 [2]. The domain is often associated with family fn3, Pfam:PF00041.	Domain

Gene Ontology: Gene Product Annotation Gene Ontology Database Homepage

Chains	Polymer	Molecular Function	Biological Process	Cellular Component
F, J	Nanobody 37D5	-	-	-
A, C	Interleukin-23 subunit alpha	protein binding binding molecular function activator activity signaling receptor binding molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity interleukin-23 receptor binding cytokine receptor binding	regulation of defense response regulation of biological process response to stimulus regulation of response to external stimulus defense response biological regulation positive regulation of biological process response to external stimulus regulation of inflammatory response positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stimulus regulation of response to stress response to stress regulation of defense response regulation of biological process response to stimulus regulation of response to external stimulus defense response biological regulation positive regulation of biological process response to external stimulus regulation of inflammatory response positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stimulus regulation of response to stress response to stress positive regulation of defense response inflammatory response adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of T-helper 17 type immune response immune response regulation of adaptive immune response positive regulation of T-helper 17 type immune response adaptive immune response regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of immune response immune system process regulation of immune response regulation of immune system process positive regulation of adaptive immune response positive regulation of immune system process T-helper 17 type immune response positive regulation of T-helper 1 type immune response T-helper 1 type immune response regulation of T-helper 1 type immune response biological process involved in interspecies interaction between organisms response to other organism defense response to symbiont response to biotic stimulus defense response to other organism innate immune response response to external biotic stimulus multicellular organismal process regulation of cellular process positive regulation of cell population proliferation regulation of leukocyte activation regulation of cell activation lymphocyte activation positive regulation of natural killer cell proliferation leukocyte proliferation leukocyte activation positive regulation of lymphocyte activation positive regulation of cell activation lymphocyte proliferation positive regulation of leukocyte activation positive regulation of mononuclear cell proliferation regulation of multicellular organismal process regulation of natural killer cell activation positive regulation of cellular process regulation of lymphocyte proliferation regulation of leukocyte proliferation cell population proliferation cell activation positive regulation of lymphocyte proliferation positive regulation of natural killer cell activation natural killer cell activation natural killer cell proliferation mononuclear cell proliferation regulation of cell population proliferation positive regulation of leukocyte proliferation regulation of mononuclear cell proliferation positive regulation of multicellular organismal process cellular process regulation of lymphocyte activation regulation of natural killer cell proliferation tissue remodeling regulation of interleukin-12 production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process cytokine production regulation of cytokine production positive regulation of macromolecule metabolic process interleukin-12 production regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of interleukin-12 production regulation of gene expression biosynthetic process positive regulation of gene expression metabolic process regulation of macromolecule biosynthetic process macromolecule metabolic process positive regulation of cytokine production regulation of metabolic process cellular response to stimulus positive regulation of locomotion regulation of cell motility positive regulation of chemotaxis positive regulation of cell migration positive regulation of neutrophil chemotaxis taxis cell migration chemotaxis regulation of leukocyte chemotaxis regulation of leukocyte migration positive regulation of leukocyte chemotaxis neutrophil migration granulocyte migration leukocyte migration positive regulation of granulocyte chemotaxis response to chemical regulation of locomotion regulation of neutrophil chemotaxis regulation of neutrophil migration neutrophil chemotaxis regulation of granulocyte chemotaxis positive regulation of cell motility myeloid leukocyte migration regulation of cell migration cell motility locomotion cell chemotaxis positive regulation of leukocyte migration positive regulation of neutrophil migration regulation of chemotaxis cellular response to chemical stimulus granulocyte chemotaxis leukocyte chemotaxis negative regulation of interleukin-10 production negative regulation of biological process interleukin-10 production negative regulation of cellular process regulation of interleukin-10 production negative regulation of macromolecule metabolic process negative regulation of metabolic process negative regulation of cytokine production negative regulation of gene expression negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of multicellular organismal process positive regulation of tissue remodeling regulation of tissue remodeling T cell activation T cell proliferation cell surface receptor signaling pathway via STAT cell surface receptor signaling pathway signaling cell communication signal transduction cell surface receptor signaling pathway via JAK-STAT positive regulation of T cell activation positive regulation of T cell proliferation positive regulation of activated T cell proliferation regulation of leukocyte cell-cell adhesion regulation of activated T cell proliferation positive regulation of leukocyte cell-cell adhesion leukocyte cell-cell adhesion activated T cell proliferation positive regulation of cell-cell adhesion cell adhesion cell-cell adhesion regulation of cell-cell adhesion positive regulation of cell adhesion regulation of cell adhesion regulation of T cell activation regulation of T cell proliferation regulation of alpha-beta T cell activation positive regulation of T cell differentiation alpha-beta T cell differentiation involved in immune response regulation of cell development multicellular organism development cell differentiation regulation of T-helper cell differentiation alpha-beta T cell activation positive regulation of CD4-positive, alpha-beta T cell differentiation T-helper cell differentiation alpha-beta T cell lineage commitment positive regulation of cell development immune effector process T-helper 17 cell differentiation cell fate commitment CD4-positive or CD8-positive, alpha-beta T cell lineage commitment positive regulation of alpha-beta T cell differentiation regulation of developmental process cell development CD4-positive, alpha-beta T cell differentiation positive regulation of T-helper 17 cell differentiation positive regulation of T-helper cell differentiation regulation of T cell differentiation alpha-beta T cell differentiation T cell activation involved in immune response positive regulation of cell differentiation leukocyte activation involved in immune response positive regulation of immune effector process regulation of T-helper 17 cell differentiation hemopoiesis regulation of CD4-positive, alpha-beta T cell activation regulation of immune effector process regulation of leukocyte differentiation mononuclear cell differentiation regulation of cell differentiation lymphocyte differentiation cell activation involved in immune response CD4-positive, alpha-beta T cell differentiation involved in immune response positive regulation of developmental process positive regulation of T-helper 17 cell lineage commitment anatomical structure development T cell differentiation CD4-positive, alpha-beta T cell lineage commitment developmental process T-helper cell lineage commitment T-helper 17 cell lineage commitment positive regulation of alpha-beta T cell activation leukocyte differentiation cellular developmental process regulation of CD4-positive, alpha-beta T cell differentiation regulation of alpha-beta T cell differentiation positive regulation of CD4-positive, alpha-beta T cell activation alpha-beta T cell activation involved in immune response positive regulation of hemopoiesis CD4-positive, alpha-beta T cell activation lymphocyte activation involved in immune response positive regulation of cell fate commitment regulation of lymphocyte differentiation regulation of multicellular organismal development regulation of T-helper 17 cell lineage commitment regulation of cell fate commitment T cell differentiation involved in immune response T cell lineage commitment positive T cell selection regulation of hemopoiesis positive regulation of leukocyte differentiation T cell selection positive regulation of lymphocyte differentiation positive regulation of phosphorylation positive regulation of phosphate metabolic process regulation of primary metabolic process regulation of phosphate metabolic process peptidyl-amino acid modification phosphate-containing compound metabolic process protein modification process phosphorus metabolic process positive regulation of protein phosphorylation tyrosine phosphorylation of STAT protein protein phosphorylation positive regulation of phosphorus metabolic process phosphorylation regulation of protein metabolic process primary metabolic process macromolecule modification regulation of phosphorus metabolic process regulation of protein modification process regulation of protein phosphorylation positive regulation of protein metabolic process peptidyl-tyrosine modification positive regulation of peptidyl-tyrosine phosphorylation positive regulation of protein modification process protein metabolic process regulation of tyrosine phosphorylation of STAT protein regulation of peptidyl-tyrosine phosphorylation positive regulation of tyrosine phosphorylation of STAT protein regulation of phosphorylation peptidyl-tyrosine phosphorylation positive regulation of interleukin-10 production granulocyte macrophage colony-stimulating factor production positive regulation of granulocyte macrophage colony-stimulating factor production regulation of granulocyte macrophage colony-stimulating factor production positive regulation of cell communication positive regulation of signal transduction regulation of signal transduction regulation of non-canonical NF-kappaB signal transduction intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette regulation of signaling non-canonical NF-kappaB signal transduction positive regulation of intracellular signal transduction regulation of cell communication positive regulation of non-canonical NF-kappaB signal transduction positive regulation of signaling regulation of response to biotic stimulus regulation of defense response to virus defense response to virus positive regulation of defense response to virus by host regulation of defense response to virus by host response to virus interleukin-17 production regulation of interleukin-17 production positive regulation of interleukin-17 production defense response to Gram-negative bacterium defense response to bacterium response to bacterium positive regulation of NK T cell activation regulation of NK T cell activation NK T cell activation regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production lymphocyte mediated immunity T cell mediated immunity positive regulation of leukocyte mediated immunity positive regulation of lymphocyte mediated immunity positive regulation of leukocyte mediated cytotoxicity leukocyte mediated immunity regulation of T cell mediated immunity T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity regulation of leukocyte mediated cytotoxicity leukocyte mediated cytotoxicity regulation of leukocyte mediated immunity regulation of T cell mediated cytotoxicity regulation of lymphocyte mediated immunity positive regulation of T cell mediated immunity regulation of cell killing positive regulation of cell killing cell killing immunological memory formation process positive regulation of memory T cell differentiation memory T cell differentiation regulation of memory T cell differentiation immunological memory process positive regulation of DNA-templated transcription RNA metabolic process nucleobase-containing compound metabolic process RNA biosynthetic process nucleic acid biosynthetic process DNA-templated transcription regulation of RNA metabolic process transcription by RNA polymerase II regulation of nucleobase-containing compound metabolic process regulation of RNA biosynthetic process regulation of transcription by RNA polymerase II positive regulation of nucleobase-containing compound metabolic process positive regulation of transcription by RNA polymerase II nucleobase-containing compound biosynthetic process nucleic acid metabolic process positive regulation of RNA metabolic process positive regulation of RNA biosynthetic process regulation of DNA-templated transcription regulation of type II interferon production type II interferon production positive regulation of type II interferon production regulation of NK T cell proliferation positive regulation of NK T cell proliferation positive regulation of alpha-beta T cell proliferation alpha-beta T cell proliferation NK T cell proliferation regulation of alpha-beta T cell proliferation myeloid leukocyte differentiation positive regulation of osteoclast differentiation regulation of osteoclast differentiation osteoclast differentiation regulation of myeloid cell differentiation regulation of myeloid leukocyte differentiation positive regulation of myeloid leukocyte differentiation myeloid cell differentiation positive regulation of myeloid cell differentiation	protein-containing complex cellular anatomical structure extracellular region extracellular space interleukin-23 complex membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen protein-containing complex cellular anatomical structure extracellular region extracellular space interleukin-23 complex membrane-bounded organelle intracellular anatomical structure membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen organelle endoplasmic reticulum cytoplasm
B, D	Interleukin-12 subunit beta	interleukin-12 receptor binding protein binding binding signaling receptor binding cytokine receptor binding growth factor receptor binding protein-containing complex binding identical protein binding interleukin-12 alpha subunit binding interleukin-12 binding cytokine binding protein heterodimerization activity protein dimerization activity molecular transducer activity interleukin-12 receptor binding protein binding binding signaling receptor binding cytokine receptor binding growth factor receptor binding protein-containing complex binding identical protein binding interleukin-12 alpha subunit binding interleukin-12 binding cytokine binding protein heterodimerization activity protein dimerization activity molecular transducer activity transmembrane signaling receptor activity signaling receptor activity cytokine receptor activity immune receptor activity molecular function activator activity molecular function regulator activity cytokine activity signaling receptor regulator activity receptor ligand activity signaling receptor activator activity	negative regulation of protein transport protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of cellular process regulation of protein localization transport negative regulation of biological process negative regulation of transport protein localization to extracellular region localization negative regulation of secretion regulation of secretion by cell negative regulation of protein transport protein localization regulation of localization establishment of protein localization cellular localization nitrogen compound transport regulation of cellular process regulation of protein localization transport negative regulation of biological process negative regulation of transport protein localization to extracellular region localization negative regulation of secretion regulation of secretion by cell secretion by cell cellular macromolecule localization negative regulation of cellular process negative regulation of secretion by cell negative regulation of protein localization regulation of biological process regulation of transport secretion biological regulation regulation of establishment of protein localization establishment of protein localization to extracellular region negative regulation of establishment of protein localization export from cell regulation of protein transport protein secretion establishment of localization regulation of secretion regulation of protein secretion negative regulation of protein secretion protein transport regulation of cellular localization macromolecule localization cellular process cellular response to stimulus response to stimulus cell surface receptor signaling pathway signaling response to cytokine cytokine-mediated signaling pathway cell communication response to peptide response to chemical cellular response to cytokine stimulus signal transduction multicellular organismal process cellular developmental process cell development mononuclear cell differentiation lymphocyte activation lymphocyte differentiation cell activation involved in immune response CD4-positive, alpha-beta T cell differentiation CD4-positive, alpha-beta T cell differentiation involved in immune response alpha-beta T cell differentiation involved in immune response leukocyte activation alpha-beta T cell differentiation T cell activation involved in immune response alpha-beta T cell activation involved in immune response T cell activation cell differentiation CD4-positive, alpha-beta T cell activation leukocyte activation involved in immune response anatomical structure development alpha-beta T cell activation T cell differentiation lymphocyte activation involved in immune response developmental process T-helper cell differentiation immune response hemopoiesis cell activation T cell differentiation involved in immune response immune effector process immune system process leukocyte differentiation regulation of defense response regulation of response to external stimulus defense response positive regulation of biological process response to external stimulus regulation of inflammatory response positive regulation of response to stimulus positive regulation of response to external stimulus positive regulation of inflammatory response regulation of response to stimulus regulation of response to stress response to stress positive regulation of defense response inflammatory response natural killer cell activation natural killer cell activation involved in immune response response to light stimulus response to radiation response to abiotic stimulus response to UV response to UV-B cellular response to interleukin-12 response to interleukin-12 interleukin-12-mediated signaling pathway positive regulation of T-helper 1 type immune response adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains regulation of adaptive immune response T-helper 1 type immune response adaptive immune response regulation of T-helper 1 type immune response regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains positive regulation of immune response regulation of immune response regulation of immune system process positive regulation of adaptive immune response positive regulation of immune system process cell migration cell motility positive regulation of tissue remodeling tissue remodeling positive regulation of multicellular organismal process regulation of multicellular organismal process regulation of tissue remodeling biological process involved in interspecies interaction between organisms response to other organism defense response to protozoan response to biotic stimulus response to protozoan defense response to other organism response to external biotic stimulus cell population proliferation leukocyte proliferation mononuclear cell proliferation lymphocyte proliferation T cell proliferation cell surface receptor signaling pathway via STAT cell surface receptor signaling pathway via JAK-STAT regulation of alpha-beta T cell activation regulation of leukocyte activation regulation of cell activation positive regulation of T cell differentiation regulation of cell development multicellular organism development regulation of T-helper cell differentiation positive regulation of CD4-positive, alpha-beta T cell differentiation alpha-beta T cell lineage commitment positive regulation of cell development regulation of leukocyte cell-cell adhesion T-helper 17 cell differentiation cell fate commitment CD4-positive or CD8-positive, alpha-beta T cell lineage commitment positive regulation of alpha-beta T cell differentiation regulation of developmental process positive regulation of leukocyte cell-cell adhesion positive regulation of T-helper 17 cell differentiation positive regulation of T-helper cell differentiation positive regulation of cell-cell adhesion regulation of T cell differentiation positive regulation of lymphocyte activation positive regulation of cell differentiation positive regulation of immune effector process regulation of cell-cell adhesion positive regulation of cellular process regulation of T-helper 17 cell differentiation regulation of cell adhesion positive regulation of T-helper 17 type immune response regulation of CD4-positive, alpha-beta T cell activation regulation of lymphocyte activation regulation of immune effector process regulation of leukocyte differentiation regulation of cell differentiation positive regulation of developmental process positive regulation of cell activation positive regulation of T-helper 17 cell lineage commitment positive regulation of leukocyte activation CD4-positive, alpha-beta T cell lineage commitment positive regulation of T cell activation T-helper cell lineage commitment T-helper 17 cell lineage commitment positive regulation of alpha-beta T cell activation regulation of CD4-positive, alpha-beta T cell differentiation regulation of alpha-beta T cell differentiation leukocyte cell-cell adhesion positive regulation of CD4-positive, alpha-beta T cell activation cell adhesion cell-cell adhesion positive regulation of hemopoiesis positive regulation of cell fate commitment regulation of lymphocyte differentiation regulation of multicellular organismal development regulation of T-helper 17 cell lineage commitment regulation of T-helper 17 type immune response regulation of cell fate commitment positive regulation of cell adhesion regulation of T cell activation T cell lineage commitment positive T cell selection regulation of hemopoiesis positive regulation of leukocyte differentiation T cell selection positive regulation of lymphocyte differentiation T-helper 17 type immune response regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis endothelial cell proliferation angiogenesis negative regulation of endothelial cell proliferation tube morphogenesis epithelial cell proliferation blood vessel development system development negative regulation of cell population proliferation negative regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis blood vessel morphogenesis tube development blood vessel endothelial cell proliferation involved in sprouting angiogenesis sprouting angiogenesis vasculature development circulatory system development anatomical structure morphogenesis regulation of endothelial cell proliferation regulation of cell population proliferation anatomical structure formation involved in morphogenesis regulation of epithelial cell proliferation negative regulation of epithelial cell proliferation interleukin-10 production positive regulation of macromolecule biosynthetic process positive regulation of metabolic process positive regulation of biosynthetic process regulation of cytokine production cytokine production positive regulation of macromolecule metabolic process regulation of interleukin-10 production regulation of biosynthetic process regulation of macromolecule metabolic process gene expression macromolecule biosynthetic process positive regulation of interleukin-10 production regulation of gene expression biosynthetic process positive regulation of gene expression regulation of macromolecule biosynthetic process metabolic process macromolecule metabolic process positive regulation of cytokine production regulation of metabolic process regulation of leukocyte proliferation positive regulation of cell population proliferation positive regulation of leukocyte proliferation positive regulation of mononuclear cell proliferation regulation of mononuclear cell proliferation regulation of lymphocyte proliferation positive regulation of lymphocyte proliferation negative regulation of inflammatory response inflammatory response to antigenic stimulus negative regulation of inflammatory response to antigenic stimulus negative regulation of response to stimulus negative regulation of immune response regulation of inflammatory response to antigenic stimulus negative regulation of immune system process negative regulation of response to external stimulus negative regulation of defense response cellular response to growth factor stimulus negative regulation of vascular endothelial growth factor signaling pathway negative regulation of signaling regulation of signal transduction negative regulation of cellular response to growth factor stimulus negative regulation of cell communication cell surface receptor protein tyrosine kinase signaling pathway cellular response to endogenous stimulus regulation of vascular endothelial growth factor signaling pathway enzyme-linked receptor protein signaling pathway regulation of signaling regulation of cellular response to vascular endothelial growth factor stimulus response to endogenous stimulus regulation of cellular response to growth factor stimulus negative regulation of signal transduction vascular endothelial growth factor signaling pathway regulation of cell communication cellular response to vascular endothelial growth factor stimulus response to growth factor negative regulation of cellular response to vascular endothelial growth factor stimulus regulation of response to biotic stimulus defense response to symbiont regulation of defense response to virus defense response to virus positive regulation of defense response to virus by host regulation of defense response to virus by host response to virus defense response to Gram-negative bacterium defense response to bacterium response to bacterium regulation of natural killer cell activation positive regulation of natural killer cell activation positive regulation of NK T cell activation regulation of NK T cell activation NK T cell activation lymphocyte mediated immunity positive regulation of response to biotic stimulus positive regulation of leukocyte mediated immunity positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target immune response to tumor cell positive regulation of leukocyte mediated cytotoxicity positive regulation of natural killer cell mediated immunity regulation of natural killer cell mediated cytotoxicity directed against tumor cell target leukocyte mediated immunity regulation of natural killer cell mediated immune response to tumor cell natural killer cell mediated immunity regulation of natural killer cell mediated immunity positive regulation of immune response to tumor cell regulation of innate immune response leukocyte mediated cytotoxicity natural killer cell mediated immune response to tumor cell regulation of leukocyte mediated immunity natural killer cell mediated cytotoxicity regulation of cell killing positive regulation of natural killer cell mediated cytotoxicity positive regulation of cell killing positive regulation of response to tumor cell regulation of natural killer cell mediated cytotoxicity positive regulation of lymphocyte mediated immunity positive regulation of natural killer cell mediated immune response to tumor cell regulation of response to tumor cell innate immune response response to tumor cell positive regulation of innate immune response regulation of leukocyte mediated cytotoxicity regulation of immune response to tumor cell natural killer cell mediated cytotoxicity directed against tumor cell target regulation of lymphocyte mediated immunity cell killing negative regulation of macromolecule metabolic process interleukin-17 production negative regulation of interleukin-17 production negative regulation of metabolic process negative regulation of cytokine production negative regulation of gene expression regulation of interleukin-17 production negative regulation of biosynthetic process negative regulation of macromolecule biosynthetic process negative regulation of multicellular organismal process T cell mediated immunity regulation of T cell mediated immunity T cell mediated cytotoxicity positive regulation of T cell mediated cytotoxicity regulation of T cell mediated cytotoxicity positive regulation of T cell mediated immunity positive regulation of T cell proliferation regulation of T cell proliferation sexual reproduction reproductive process regulation of smooth muscle cell proliferation smooth muscle cell proliferation negative regulation of smooth muscle cell proliferation muscle cell proliferation response to lipid cellular response to lipopolysaccharide response to oxygen-containing compound cellular response to molecule of bacterial origin response to lipopolysaccharide cellular response to oxygen-containing compound cellular response to biotic stimulus cellular response to chemical stimulus cellular response to lipid response to molecule of bacterial origin positive regulation of natural killer cell proliferation natural killer cell proliferation regulation of natural killer cell proliferation regulation of interleukin-12 production interleukin-12 production positive regulation of interleukin-12 production negative regulation of interleukin-10 production positive regulation of activated T cell proliferation regulation of activated T cell proliferation activated T cell proliferation positive regulation of programmed cell death positive regulation of smooth muscle cell apoptotic process muscle cell apoptotic process smooth muscle cell apoptotic process regulation of apoptotic process regulation of muscle cell apoptotic process regulation of programmed cell death cell death regulation of smooth muscle cell apoptotic process positive regulation of apoptotic process positive regulation of muscle cell apoptotic process apoptotic process programmed cell death response to type II interferon cellular response to type II interferon granulocyte macrophage colony-stimulating factor production positive regulation of protein metabolic process positive regulation of granulocyte macrophage colony-stimulating factor production regulation of primary metabolic process protein metabolic process regulation of granulocyte macrophage colony-stimulating factor production regulation of protein metabolic process primary metabolic process positive regulation of cell communication positive regulation of signal transduction regulation of non-canonical NF-kappaB signal transduction intracellular signal transduction regulation of intracellular signal transduction intracellular signaling cassette non-canonical NF-kappaB signal transduction positive regulation of intracellular signal transduction positive regulation of non-canonical NF-kappaB signal transduction positive regulation of signaling positive regulation of interleukin-17 production regulation of tumor necrosis factor production positive regulation of tumor necrosis factor superfamily cytokine production tumor necrosis factor superfamily cytokine production positive regulation of tumor necrosis factor production tumor necrosis factor production regulation of tumor necrosis factor superfamily cytokine production immunological memory formation process positive regulation of memory T cell differentiation memory T cell differentiation regulation of memory T cell differentiation immunological memory process regulation of type II interferon production type II interferon production positive regulation of type II interferon production regulation of NK T cell proliferation positive regulation of NK T cell proliferation positive regulation of alpha-beta T cell proliferation alpha-beta T cell proliferation NK T cell proliferation regulation of alpha-beta T cell proliferation myeloid leukocyte differentiation positive regulation of osteoclast differentiation regulation of osteoclast differentiation osteoclast differentiation regulation of myeloid cell differentiation regulation of myeloid leukocyte differentiation positive regulation of myeloid leukocyte differentiation myeloid cell differentiation positive regulation of myeloid cell differentiation	cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane protein-containing complex extracellular region extracellular space interleukin-23 complex intracellular anatomical structure cytoplasm cytosol cell periphery cellular anatomical structure cell surface membrane plasma membrane external side of plasma membrane side of membrane protein-containing complex extracellular region extracellular space interleukin-23 complex intracellular anatomical structure cytoplasm cytosol receptor complex membrane-bounded organelle membrane-enclosed lumen intracellular membrane-bounded organelle endomembrane system intracellular organelle lumen endoplasmic reticulum lumen intracellular organelle organelle lumen organelle endoplasmic reticulum interleukin-12 complex endosome intracellular vesicle cytoplasmic vesicle late endosome late endosome lumen endosome lumen vesicle
E, G	Nanobody 124C4	-	-	-
H, I	Nanobody 22E11	-	-	-

InterPro: Protein Family Classification InterPro Database Homepage

Chains	Accession	Name	Type
A, C	IPR009079	Four-helical cytokine-like, core	Homologous Superfamily
A, C	IPR010831	Interleukin-23 alpha	Family
B, D	IPR036179	Immunoglobulin-like domain superfamily	Homologous Superfamily
B, D	IPR003530	Long hematopoietin receptor, soluble alpha chain, conserved site	Conserved Site
B, D	IPR013783	Immunoglobulin-like fold	Homologous Superfamily
B, D	IPR007110	Immunoglobulin-like domain	Domain
B, D	IPR003598	Immunoglobulin subtype 2	Domain
B, D	IPR050676	Interleukin-12	Family
B, D	IPR019482	Interleukin-12 beta, central domain	Domain
B, D	IPR015528	Interleukin-12 beta	Family
B, D	IPR003961	Fibronectin type III	Domain
B, D	IPR036116	Fibronectin type III superfamily	Homologous Superfamily

Pharos: Disease Associations Pharos Homepage Annotation

Chains	Drug Target	Associated Disease
A, C	Pharos: Q9NPF7	psoriasis rheumatoid arthritis pustulosis palmaris et plantaris Crohn disease lung cancer psoriatic arthritis spina bifida diabetes mellitus Plaque psoriasis tuberculosis skin disease ulcerative colitis
B, D	Pharos: P29460	psoriasis psoriatic arthritis ankylosing spondylitis Crohn disease ulcerative colitis primary biliary cholangitis mendelian susceptibility to mycobacterial diseases due to complete IL12B deficiency malignant glioma Takayasu arteritis malignant mesothelioma Neoplasms, Experimental pulmonary fibrosis systemic lupus erythematosus liver cancer mixed glioma psoriasis psoriatic arthritis ankylosing spondylitis Crohn disease ulcerative colitis primary biliary cholangitis mendelian susceptibility to mycobacterial diseases due to complete IL12B deficiency malignant glioma Takayasu arteritis malignant mesothelioma Neoplasms, Experimental pulmonary fibrosis systemic lupus erythematosus liver cancer mixed glioma pustulosis palmaris et plantaris liver neoplasm Crohn's colitis glioma ileocolitis psoriasis 11, susceptibility to schizophrenia inflammatory bowel disease skin disease idiopathic interstitial pneumonia leprosy

RCSB PDB Core Operations are funded by the U.S. National Science Foundation (DBI-2321666), the US Department of Energy (DE-SC0019749), and the National Cancer Institute, National Institute of Allergy and Infectious Diseases, and National Institute of General Medical Sciences of the National Institutes of Health under grant R01GM157729.